Barbital sodium

From the information provided below, find the displacement value of pheno-barbital sodium ... 

Dissolve 4.88 g barbital-sodium (Veronal, sodium diethylbar-biturate) and 3.23 g sodium acetate trihydrate in about 800 ml ddH20. Adjust pH to 8.6 with 0.1 N HCl (consumption about 30 ml), then fill up to 1000 ml. 

Mix 50mLof a solution in water containing 19.44 g per liter of sodium acetate R and 29.46 per liter of barbital sodium R with 50.5 mLof 0.1 N hydrochloric acid, add 20 mL of an 8.5% m/V solution of sodium chloride R. and dilute to 250 mL with water. 

Rats, placed in individual macrolon cages (25 x 19 x 13 cm), are injected with barbital sodium (150 mg/kg i.p.). The latency to sleep and the duration of sleep (maximum 6 hours after barbital injection) are then recorded. Sleep is indicated by loss of the righting reflex. To avoid disturbing the experiment, no righting reflex test is performed before 50 minutes has elapsed after barbital injection (i.e. minimum sleep latency = 50 minutes). 

All prescription-only medicines may be supplied by emergency supply at the request of a practitioner, except controlled drugs in Schedules 1, 2 and 3 of the Misuse of Drugs Regulations (apart from phenobarbital or pheno-barbital sodium for the treatment of epilepsy). Please note that the emergency supply of phenobarbital or phenobarbital sodium for the treatment of a medical condition other than epilepsy would therefore be unlawful. 

Titan Gel lEP plate No. 3047. Plates contain 1% agarose (w/v) in barbital-sodium barbital buffer with 0.1% sodium azide added as a preservative. The plates are ready for use as packaged and should be stored horizontally at 15 to 30 C. Discard plates if they appear cloudy, show bacterial growth, or have been frozen or in excessive heat. 

Antiserum to Human Kappa No. 9262 Barbital/sodium barbital ... 

Sodium salt. ClH1]N1NaOj, barbital sodium, sodium 5,5-dicthvibarbiturate, barbitone sodium, soluble barbital, sodium diethylmalonylurea, Veronal sodium, Medinal, Embinat. Bitter crystals or powder. One gtam dissolves in 5 ml water. 2.5 ml boiling water, 400 ml ale. Aq soln is alkaline to litmus and pbenolphthalein. pH of 0.1 molar aq soln, 9.4. 

S M barbital-sodium barbital buffer (pH 8.6) (for plasma proteins) containing 3 mM calcium lactate. The gels are prepared by suspending 1.5 g of agarose in 100 ml of barbital buffer and the suspension is heated until a clean solution is obtained. Then the agarose solution is cooled to 60°C, and 25 ml are poured over a... 

The onset of action for long acting barbiturates is visible after an hour or so, and the duration of action lasts for 6-10 hours. They are largely excreted by the kidney. Examples Barbitone Barbital Sodium Phenobarbital Methyl-phenobarbital. 

Being water-soluble, barbital sodium is more readily absorbed than its parent eompound barbital. Owing to its slow rate of excretion there exists an element of risk of a cumulative action. 

Coumarins isolated from fragrant angelica administered orally to rats in single doses of 25,50, or 100 mg/kg increased the duration of hypnosis induced by pentobarbital sodium. The 100 mg/kg dose also prolonged the latent period and shortened the duration of hypnosis induced by barbital sodium (Liu et al. 2006). 

Liu, Z., J. Li, and J. Wu. 2006. [Influence of coumarins from Radix AngeUcae Dahuricae on the hypnotic effects of pentobarbital sodium and barbital sodium in mice]. Med. f. Wuhan Univ. 27(l) 63-65. 

Barbital sodium Chlorothen citrate Didexamethasone-21 -phosphate... 

For use, mix 291 ml of solution (a) with 709 ml of solution (6), producing a solution of pH 10. (If necessary, adjust to this value.) Normal saline solution 0.9% aqueous solution of sodium chloride. Buffer solution for electrophoresis dissolve 30.0 g of barbital sodium (= Veronal sodium), 20.0 g of sodium acetate trihydrate, and 0.3 g of anhydrous calcium chloride in water, add 180 ml of 0. IN hydrochloric acid solution and then sufficient water to make 4,000 ml of solution pH = 8.6 r = 0.06. 

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