Back pain intravenous

Vitamins Ki and K2 require bile salts for absorption from the intestinal tract. Vitamin Kl is available clinically in oral and parenteral forms. Onset of effect is delayed for 6 hours but the effect is complete by 24 hours when treating depression of prothrombin activity by excess warfarin or vitamin deficiency. Intravenous administration of vitamin Ki should be slow, because rapid infusion can produce dyspnea, chest and back pain, and even death. Vitamin repletion is best achieved with intravenous or oral administration, because its bioavailability after subcutaneous administration is erratic. Vitamin Ki is... 

Acute hypersensitivity reactions have been reported with the first infusion of pegylated liposomal doxorubicin (14,15). The symptoms included flushing, shortness of breath, facial swelling, headache, chills, back pain, tightness in the chest and throat, and hypotension. Similar reactions have been reported after the intravenous administration of colloid imaging agents and unloaded liposomes. 

A 14-year-old girl, perinatally infected with HIV, had a medical history of recurrent infections that had been treated with several antibiotics, including ceftriaxone. She was given ceftriaxone (60 mg/kg intravenously) for pneumonia and 30 minutes later complained of severe back pain, became nauseated, vomited, and collapsed. Despite intensive medical care she died within a few hours with massive intravascular hemolysis and disseminated intravascular coagulopathy. Autopsy was refused. 

An intravenous infusion of an emulsion of perflubron as a hepatic and splenic enhancement agent during CT examination caused lower back pain and transient fever (SEDA-15, 505). This problem appeared to be due to the lipid emulsion and seems to have been overcome with more recent formulations. 

When 9 or 18 /ig/kg/day of DAB g-IL-2 is given as an intravenous infusion for 5 consecutive days every 3 weeks for up to 6 months, the overall response rate was 36% with 18 pg/kg/day and 23% with 9 pg/kg/day. Adverse effects included pain, fevers, chills, nausea, vomiting, and diarrhea. Immediate hypersensitivity manifested by hypotension, back pain, dyspnea, and chest pain occurred in 60% of patients within 24 hours of drug administration other serious side effects are edema, hypoalbuminemia, and/or hypotension, occurring in 20-30% of patients, and elevated blood levels of hepatic transaminases. 

Intravenous administration of wild lettuce extract led to fevers, chills, abdominal and back pain, neck stiffness, headache, elevated white blood cell counts, and mild liver function abnormalities (Mullins and Horowitz 1998). Such effects are not expected after oral use of wild lettuce. 

There have been two independent reports of acute disabling low back pain in two elderly patients for the first time during intravenous amiodarone administration, requiring withdrawal in one case oral amiodarone was well tolerated. Local nerve irritation by the solvent in which amiodarone is dissolved, in the presence of chronic arthropathy, is a possible mechanism [37", 38" ]. 

Manzano-Fern ndez S, Sanchez M, Moreno-Flores V, Garcia-Alberola A. Acute disabling low-back pain during intravenous administration of amiodarone could intravenous to oral switch therapy be a safe strategy Cardiology 2010 117 (4) 275-7. 

Tsikrikas S, Charalampous C, Letsas KP, Efremidis M, Sideris A. Low back pain following intravenous administration of amiodarone. Hellenic J Cardiol 2010 51 (6) 544-5. 

Three hours later, the patient received 21 000 units of heparin in preparation for cardiopulmonary bypass (CPB). After CPB the heparin was reversed with protamine. Forty-nine hours post-operatively, intravenous heparin was started for thrombophylaxis of the prosthetic aortic valve. Fifty-three hours post-operatively, the PICC line became clotted and 2 mg of alteplase was administered. Intense back pain and blood in the epidural catheter and around the epidural 205 puncture site were noted. The pediatric team removed... 

The 220 trial participants had chronic nonradicu-lopathic low back pain for at least 3 months that required regular analgesic medication. Investigators report a single intravenous infusion of Tanezumab 200 pg/kg provided durable efficacy over a 12-week period (Table 131.1). 

In a multicenter study of 375 patients who received a lymph node-specific contrast agent (USPIO) ferumoxtran-10 (Sinerem, Guerbet, France) by intravenous infusion, there were no serious adverse events [33 ]. In six patients low back pain during the infusion resolved after the infusion was stopped and did not recur when the infusion was restarted about 10 minutes later. Other minor adverse events were diarrhea and abdominal cramps ( = 9), pruritus and urticaria n = 4), and headache (n = 2). 

Pain There are a few cases reporting low back pain as a reaction to intravenous administration of amiodarone [19]. This effect, however, resolves after the discontinuation of the infusion. Notably intravenous and rarely oral administrations of amiodarone were related to several adverse effects. This may indicate that other constituents within the intravenous solution could be the possible causative agent. It was previously reported that an excipient used to stabilise aqueous formulations of amiodarone infusion - polysorbate-80 - could be implicated in a variety of adverse reactions. The proposed mechanism for epigastric and low back pain occurrence is a hypotensive response caused by polysorbate-80, which in turn results in transient secondary mesenteric ischaemia. A marked release of histamine is the cause of the resulting hypotension. However, amiodarone s vasodilating effect as a cause of the back pain cannot be totally excluded. 

Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of prostate cancer (PCa) cells, particularly in androgen-independent, advanced, and metastatic disease. N-[N-[(S)-l,3-dicarboxypropyl]carbamoyl]-4- F-fluorobenzyl-L-cysteine ( F-DCFBC) could image an experimental model of PSMA-positive PCa using PET. Three adverse events occurred in five patients with metastatic PCa who received intravenous administration of 370 MBq (10 mCi) of F-DCFBC. Two patients experienced grade three blood pressure events using the CTCAE. A third patient experienced lower back pain. Patients did not experience any severe adverse events [til ll. 

A 56-year-old woman diagnosed with cerebral circulation insufficiency was given an intravenous infusion of Safflower injection 20 ml in 250 ml 0.9% NaCl once every day. After two days, the patient complained of low back pain and reduced and bloody urination. The urine test showed red blood cell and protein. The Safflower injection was withdrawn immediately, and she was given an infusion of sodium ferulate injection once a day. 

Side effects which follow the intravenous injection of diazoxide also include peculiar taste sensations, nausea and vomiting after the injection, abdominal pain or low back pain and constipation. A burning sensation along the vein into which the drug is injected is often mentioned extravasation may lead to tissue necrosis and can cause extreme pain (105, 106, nos IIF). Haematological reactions include neutropenia, thrombocytopenia and eosinophilia (I05 ). Episodes of haemolysis concurrent with the use of diazoxide over several days were observed in a 26-year-old Nigerian male with severe hypertension and impaired renal function (112 ),... 

The mainstay of treatment for vaso-occlusive crisis includes hydration and analgesia (see Table 65-7). Pain may involve the extremities, back, chest, and abdomen. Patients with mild pain crises may be treated as outpatients with rest, warm compresses to the affected (painful) area, increased fluid intake, and oral analgesia. Patients with moderate to severe crises should be hospitalized. Infection should be ruled out because it may trigger a pain crisis, and any patient presenting with fever or critical illness should be started on empirical broad-spectrum antibiotics. Patients who are anemic should be transfused to their baseline. Intravenous or oral fluids at 1.5 times maintenance is recommended. Close monitoring of the patient s fluid status is important to avoid overhydration, which can lead to ACS, volume overload, or heart failure.6,27... 

In the hospital, he receives fluids and metronidazole 500 mg every 8 hours intravenously. Stool was sent for C. difficile toxin assay, which came back positive. The patient continues to have abdominal pain but no bowel movement. On day 3 of hospitalization, his abdomen is distended with diffuse pain. His white blood cell count remains elevated. A CT scan of the abdomen showed colonic dilatation to greater than 6 cm. The patient became febrile and hypotensive, requiring multiple pharmacologic support for hypotension. 

A 23-year-old woman developed chest, back, and neck pain, and surgical emphysema over the chest and neck 7 hours after taking ecstasy. She had surgical emphysema in the mediastinum and neck and was given intravenous fluids and antibiotics. 

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