Prostate specific membrane antigen

Lupoid SE, Hicke BJ, Lin Y et al (2002) Identification and characterization of nuclease-stahfiized RNA molecules that hind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Res 62 4029 033... [Pg.38]

Capromab pendetide is a murine monoclonal antibody specific for prostate specific membrane antigen. It is coupled to isotopic indium (111In) and is used in immunoscintigraphy for patients with biopsy-confirmed prostate cancer and post-prostatectomy in patients with rising prostate specific antibody level to determine extent of disease. [Pg.1198]

Burger MJ, Tebay MA, Keith PA, Samaratunga HM, Clements J, Lavin MF, Gardiner RA. Expression analysis of delta-catenin and prostate-specific membrane antigen their potential as diagnostic markers for prostate cancer. Int J Cancer 2002 100 228-237. [Pg.410]

In one study, PLG microspheres bound to DNA using a cryogenic double emulsion process and injected intramuscularly into mice were found to promote transgene expression for up to 174 days after injection, dependent upon microsphere mass. More recently nanoparticles were constructed from carboxy terminated, PEG modified PGL polymers. These particles were conjugated with an aptamer to the prostate specific membrane antigen and evaluated for in vivo biodistribution in an LNCaP (PSMA+) xenograft mouse model of prostate cancer. In this study, the aptamer caused a 3.77-fold increase in polymer concentration in the tumor tissue after retro-orbital injection (79). [Pg.24]

The role of bioreceptor can be also played by viruses covalently attached to the electrode surface, which was shown for resistance detection of antibody and prostate-specific membrane antigen.135 Taking into account up to 1020 unique species, phage-displayed libraries provide a vast pool of candidate receptors to practically any analyte, including small molecules, proteins and nucleic acids. Piezoelectric virus sensor has been developed e.g. for detection of distinctive antigens of the human cytomegalovirus.136... [Pg.51]

Determine if there is expression of cell-specific products, cell-specific structures, and transcription factors or receptors that are unique identifiers of cell types (e.g., neuroendocrine granules, peptide hormones, thyroglobulin, PSA, prostate-specific membrane antigen, inhibin, gross cystic disease fluid protein [GCDEP], villin, uroplakin, thyroid transcription factor-1 [TTE-1] or transcription factor CDX-2). [Pg.209]

Prostate-specific membrane antigen, prostate-specific antigen (PSA), and prostatic acid phosphatase used together provide a sensitive and specific panel for diagnosis of prostatic carcinoma at metastatic site. [Pg.234]

Murphy GP, Elgamal AA, Su SL, et al. Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen. Cancer. 1998 83 2259-2269. [Pg.253]

Silver DA, Pellicer I, Fair WR, et al. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res. 1997 3 81-85. [Pg.253]

Murphy GP, Barren RJ, Erickson SJ, et al. Evaluation and comparison of two new prostate carcinoma markers. Free-prostate specific antigen and prostate specific membrane antigen. Cancer. 1996 78 809-818. [Pg.253]

Troyer JK, Beckett ML, Wright Jr GL. Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line. Prostate. 1997 30 232-242. [Pg.253]

Murphy GP, Tino WT, Holmes EH, et al. Measurement of prostate-specific membrane antigen in the serum with a new antibody. Prostate. 1996 28 266-271. [Pg.253]

Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein that is expressed in prostate tissue and to a lesser extent in peripheral and central nervous system, small intestinal, and salivary gland... [Pg.594]

As mentioned earlier in the section on prostate, PSA and PSAP have proven to be useful in identifying prostate lineage. However, the sensitivities of PSA and PSAP decrease in poorly differentiated PCa and newer markers such as prostein (P501S), prostate-specific membrane antigen (PSMA), proPSA (pPSA), and NKX3.U may be of added utility. Combining these markers with urothelial lineage markers such as thrombomodulin and... [Pg.623]

Ghang SS, Reuter VE, Heston WD, Gaudin PB. Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinoma. Urology. 2001 57 1179. [Pg.650]

Marchal C, Redondo M, Padilla M, et al. Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia. Histol Histopathol. 2004 19 715. [Pg.650]

Yao V, Parwani A, Maier C, et al. Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis. Cancer Res.2008 68 9070. [Pg.650]

Ross JS, Sheehan GE, Fisher HA, et al. Gorrelation of primary tumor prostate-specific membrane antigen expression with disease recurrence in prostate cancer. Clin Cancer Res. 2003 9 6357. [Pg.650]

Chang SS, Reuter VE, Heston WD, et al. Short term neoadjuvant androgen deprivation therapy does not affect prostate specific membrane antigen expression in prostate tissues. Cancer. 2000 88 407. [Pg.650]

Bander NH, Milowsky MI, Nanus DM, et al. Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. / Clin Oncol. 2005 23 4591. [Pg.650]

Elsasser-Beile U, Wolf P, Gierschner D, et al. A new generation of monoclonal and recombinant antibodies against cell-adherent prostate specific membrane antigen for diagnostic and therapeutic targeting of prostate cancer. Prostate. 2006 66 1359. [Pg.650]

Mannweiler S, Amersdorfer P, Trajanoski S, et al. Heterogeneity of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Garcinoma with Distant Metastasis. Pathol Oncol Res. 2009 15 167-172. [Pg.650]

Olson WC, Heston WD, Rajasekaran AK. Clinical trials of cancer therapies targeting prostate-specific membrane antigen. Rev Recent Clin Trials. 2007 2 182. [Pg.650]

Aggarwal S, Singh P, Topaloglu O, et al. A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity. Cancer Res. 2006 66 9171. [Pg.655]

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