Methyl azinphos

Toxicology. Azinphos-methyl is an indirect inhibitor of cholinesterase. 

It is expected that severe exposure would produce a broad spectrum of clinical effects indicative of massive overstimulation of the cholinergic system including headache, weakness, dizziness, blurred vision, respiratory difficulty, paralysis, convulsions, and coma. 

In animals azinophos-methyl has an acute oral toxicity similar to that of parathion, although the acute dermal toxicity is less than that of parathion.  

Rats that inhaled azinphos-methyl at 4.72 mg/m 6 hours/day, 5 days/week for 12 weeks showed significant depression of red 

No selective developmental effects were observed in rats or mice administered up to 5 mg/kg/day during gestation. In another report there was no effect on fetal cholinesterase even at doses that caused significant inhibition of maternal cholinesterase in rats administered azinphos-methyl by oral gavage on gestation days 6-15 clinical effects in dams were associated with cholinesterase inhibition greater than 20%. Despite maternal toxicity no embryotox-icity was observed.  

AZINPHOS AZINFOS-M ETHYL AZINFOS AZIMPHOS GUSATHION METHYL HORODPTHOIC ACID METHYL GUTHION 

0-DIMETHYL S-((4-OXO-1,2,3-BENZOTRIAZIN-3(4H -YL)METHYL) ESTER PHOSPHORODITHIOIC ACID 0,0-DIMETHYL S-((4-OXO-1,2,3-BENZOTRIA2IN-3(4H)-YL)METHYL) ESTER PHOSPHORODITHIOIC 0,0-DIMETHYL ESTER. S-ESTER WITH 34MERCAPTOMETHYL -1,2,3-BENZOTRIAZIN -4(3H)-ONE PHOSPHORODITHIOIC ACID 

The chemical is banned. Banned for import, production, having in possession and use as agricultural pesticide. Ail formulations and uses were prohibited by the final regulatory action. Very high acute toxicity, extremely hazardous and risk to workers in formulation plant and during application by spraying. 

FAO PLANT PRODUCTION PROTECTION PAPER. Ill, 18. 1991 FAO PLANT PRODUCTION PROTECTION PAPER. 113/1 (PARTI), 3. 1992 FAO PLANT PRODUCTION PROTECTION PAPER, 113/1(PART2), 3, 1992 FAO PLANT PRODUCTION PROTECTION PAPER. 122,17.1993 FAO PLANT PRODUCTION 4 PROTECTION PAPER. 124. 11. 1993 FAO PLANT PRODUCTION 4 PROTECTION PAPER. 133, 32.1995 

IUPAC name S-(3,4-dihydro-4-oxobenzo[d]-(l,2,3)-triazin-3-ylmethyl) 0,0-dimethyl phosphorodithioate Molecular formula C10H12N3O3PS2 Toxicity class USEPA I WHO lb 

Uses Pure azinphos-methyl is a white crystalline solid technical azinphos-methyl is a brown waxy solid. Based on toxicity, the USEPA has grouped it under RUP. Azinphos-methyl is a highly persistent, broad-spectrum insecticide. It is used for the control of mites and ticks, and it is poisonous to snails and slugs. It also is used in the control of many insect pests on a wide variety of fruit, vegetable, nut, and held crops, as well as on ornamentals, tobacco, and forest and shade trees. Outside the United States, azinphos-methyl is used in lowland rice production. Azinphos-methyl is available in emulsihable liquid, liquid flowable, ultra-low volume (ULV) liquid, and wettable powder formulations.28,29 

Inhalation of the dust or aerosol preparation of azinphos-methyl may cause wheezing, tightness in the chest, blurred vision, and tearing of the eyes. Eye contact with concentrated solutions of azinphos-methyl can be life-threatening. Exposed animals and humans demonstrate respiratory difficulties, gastrointestinal problems, and CNS disturbances. 

Long-term exposure to azinphos-methyl, above the average 8-hour standard set by the Occupational Safety and Health Administration (OSHA), can impair concentration and memory, and cause headache, irritability, nausea, vomiting, muscle cramps, and dizziness. Cholinesterase inhibition from exposure to azinphos-methyl may persist for 2 to 6 weeks. Repeated exposure to small amounts may 

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Azinphos methyl Azelaic acid Aziridine Azo dyes... 

AXIOM , atrazine, 20 AXIOM , metribuzin, 20 Azathioprine, 20 Azinophos-ethyl, 20 Azinphos-methyl, 20 Azobenzene, 20 Azodiisobutyronitrile, 20 AZOLAN , amitrole, 20 Azon Litemational, 219 Azot Association, 206 Aztec Peroxides Inc., 211,219... 

Dichlorovos, phorate, dimethoate, diazinon, disulfoton, methyl-parathion, malathion, parathion, azinphos-methyl, azinphos-ethyl, and so on... 

Pesticides, e.g. dursban, azinphos-methyl, menazon, imidan, phosalone, zinophos 200-225°C, 20-120 min Induced fluorescence or amplification of natural fluorescence detection limits 10-300 ng. [20]... 

Fig. I Reflectance scan of a chromatogram track with 300 ng substance per chromatogram zone 1 = azinphos methyl, 2 = azinphos ethyl, 3 = parathion methyl, 4 = fenitrothion, 5 = parathion ethyl + phoxim.

Demeton-S-methyl sulfone (hRf 0-5), dimethoate (h/ f 5-10), demeton-S-metlq (hRf 20-25), triazophos (h/ f 40-45), azinphos-methyl (hRf 40-45), azinphos-ethj (hRf 50-55), malathion (h/ f 60-65), parathion-methyl (hRf 75-80) and parathioo ethyl (h/ f 80-85) yielded yellow to brown chromatogram zones on a light brown bact ground, with thiophosphate insecticides with P = S double bonds appearing as brow zones and those with single P — S bonds as yellow zones. 

Fig. 1 Reflectance scan of a chromatogram track with 100 ng each substance per chromatogram, one 1 = demeton-S-methyl sulfone, 2 = dimethoate, 3 = demeton-S-methyl, 4 = triazophos, 5 = azinphos-methyl, 6 = azinphos-ethyl, 7 = malathion, 8 = parathion-methyl and 9 = para-...

Sultatos LG, Woods L. 1988. The role of glutathione in the detoxification of the insecticides methyl parathion and azinphos-methyl in the mouse. Toxicol Appl Pharmacol 96 168-174. 

Of the compounds listed in Table 10.1, all except dimethoate and azinphos-methyl exist as liquids at normal temperature and pressure. Looking through the table, it can be seen that there is considerable variation in both water solubility and vapor... 

Azinphos methyl (h/ f 15-20), azinphos ethyl (liRf 20-25, parathion methyl (hiif 40-45), fenitrothion (h/ f 45—50), parathion ethyl (hR 60-65) and phoxim QxRf-. 60-65) appear as red-colored chromatogram zones on a colorless background. 

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