Autoantigens, human

N., and Ma, S. (2008) A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65). BMC Biotech., 8, 87. 

It is clear that generated by such a random process the initial repertoire of antigen specifity in all individuals of human beings should be quite similar. This implies that initially in each individal there develop lymphocytes which recognize antigens of this very individual, i.e. autoantigens. 

Verheijden GF, Rijnders AW, Bos E et al 1997 Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 40 1115—1125... 

Eystathioy, T., Chan, E. K., Tenenbaum, S. A., Keene, J. D., Griffith, K., and Fritzler, M. J. (2002). A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13,... 

Leeder, J.S., Lu, X., Timsit, Y., and Gaedigk, A., Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions, Pharmacogenetics, 8, 211, 1998. 

Bourdi, M. et al., Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis, Chem. Res. Toxicol., 9, 1159, 1996. 

Are T Cells Involved in Specific Immune Responses to Autoantigens in Atopic Dermatitis Autoimmune phenomena to human self-proteins may also contribute to the pathophysiology of atopic dermatitis. IgE against autoantigens such as Horn SI-4 have been shown to stimulate type 1 hypersensitivity reactions which in turn may contribute to the clinical cutaneous reactions in atopic dermatitis [15]. Autoallergens induce the proliferation of CLA+ autoreactive T cells derived... 

Initially characterized as an autoantigen in a human connective tissue disease [62]. May be associated with methylation induced gene silencing and heterochromatin [64,65,103]. Interacts with a component of DNA repair machinery [308]. Functions in estrogen dependent repression of Snail. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with invasive growth of breast cancers [309]. 

Lindsay, W.P. et al., KAP-2, a protein that binds to the H-box in a bean chalcone synthase promoter, is a novel plant transcription factor with sequence identity to the large subunit of human Ku autoantigen. Plant Mol Biol, 49, 503, 2002. 

They are designated golgin-84, -95, -160, -245, and -376 (giantin or macrogolgin) and were identified initially as human autoantigens (Chapter 31), appearing in the blood of persons with autoimmune disorders such as Sjogren s syndrome.281 282 Another protein... 

Burch, H. B., Nagy, E. V., Kain, K. C, Lanar, D E, Carr, F. E., Wartofsky, L., and Burman, K D (1993) Expression polymerase chain reaction for the in vitro synthesis and epitope mapping of autoantigen. Application to the human thyrotropin receptor J Immunol Methods 158, 123-130... 

Fujiwara, S., Takeo, N., Otani, Y., Parry, D. A. D., Kunimatsu, M., Lu, R., Sasaki, M., Matsuo, N., Khaleduzzaman, M., and Yoshioka, H. (2001). Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen Structure and tissue localization. / Biol. Chem. 276, 13340-13347. 

Hsu, S. et al. Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells. J Pharmacol Exp Ther. 315, 805, 2005... 

A2-restricted murine autoantigenic p cell peptide mD.p2nfull.HHD CD8 T-cell lines recognizing murine peptide Homologous human peptide Human peptide recognized by NOD. p2oPm.HHD CD8 T cells ... 

Takaki, T., Marron, M. P, Mathews, C. E., Guttman, S. T., Bottino, R., et al. (2006) HLA-A 0201 -restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J. Immunol. 176, 3257-3265. 

Viruses can induce apoptosis of human keratinocytes. These apoptotic cells can express viral antigens and autoantigens, which are coclustered in specific subsets within surface blebs and then cause challenge to self-tolerance if not cleared and processed properly (R15). Andreassen et al. showed that T cell lines specific for polyomavirus T antigen recognize T antigen complexed with nucleosomes and trigger B cells to produce anti-DNA antibodies (A20). 

Matsubara S, Yamaji Y, Sato M, Fujita J, Takahara J. Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Br J Cancer 1996 74(9) 1419-1422. 

Improved quality of autoantigen preparation (human recombinant antigen vs guinea pig liver enzyme) in ELISAs led to a diagnostic accuracy comparable to indirect immunofluorescent detection of endomysium antibodies [115, 117, 118, 120, 122-127]. These advances in ELISA technology have led to a progressive replacement of the more labor-intensive and -subjective immunofluorescent techniques. 

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