Cancer-associated retinopathy

Matsubara S, Yamaji Y, Sato M, Fujita J, Takahara J. Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Br J Cancer 1996 74(9) 1419-1422. 

Savchenko MS, Bazhin AV, Shifrina ON, Demoura SA, Kogan EA, Chuchalin AG, et al. Antirecoverin autoantibodies in the patient with non-small cell lung cancer but without cancer-associated retinopathy. Lung Cancer 2003 41(3) 363-367. 

Paraneoplastic autoimmune syndromes. Autoimmune diseases that are caused by tumour-induced perturbations of the immune system with damaging effects on various organ systems (e.g. cancer-associated retinopathy, paraneoplastic neurological syndromes, paraneoplastic cutaneous syndromes). In most cases, autoantibodies generated by antitumour immunity are responsible for the tissue injury. 

Tamoxifen is generally considered to be the antiestrogen of choice in both premenopausal and postmenopausal women with metastatic breast cancer who have tumors that are hormone receptorpositive. Tamoxifen is usually administered in 20 mg once-daily doses. There is no advantage for higher doses of tamoxifen. Moreover, long-term administration of very high doses of tamoxifen (e.g., 12 months of 60 to 100 mg/m twice daily) is associated with decreased visual acuity and retinopathy. 

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