Atorvastatin

Molecular formula C33H35FN2OS Molecular weight 558.64 CAS Registry No 134523-00-5 Merck Index 13,868 [Pg.64]

Sample preparation Mix 500 iaL serum with IS, acidify to pH 6 with sodium acetate buffer, extract with MTBE, centrifuge. Remove the organic layer and evaporate it to dryness, reconstitute the residue, inject an ahquot. [Pg.64]

Mobile phase Gradient. A B from 70 30 to 45 55 over 1 min, maintain at 45 55 for 0.5 min, return to initial conditions over 0.1 min, maintain at 70 30 for 1.9 min. A was MeOH water 88% formic acid 5 95 0.0043. B was MeCN MeOH 88% formic acid 95 5 0.0043. [Pg.64]

Internal standard deuterated atorvastatin Limit of quantitation 500 pg/mL [Pg.64]

Kantola, T. Kivisto, K.T. Neuvonen, P J. Effect of itraconazole on the pharmacokinetics of atorvastatin, Clin.Pharmacol.Ther., 1998, 64, 58-65. [Pg.64]

SPECTROPHOTOMETRIC DETERMINATION OF ATORVASTATIN AND FLUVASTATIN IN PHARMACEUTICAL PREPARATIONS AFTER DERIVATIZATION WITH 9-CHLOROMETHYLANTHRACENE... [Pg.388]

A selective and sensitive spectrophotometric method for determination of atorvastatin and fluvastatin in tablets have been developed after derivatization with 9-chloromethylanthracene. Atorvastatin and fluvastatin were reacted with 9-chloromethylanthracene in hexane and then tetrabuthylammonium hydroxide for 20 at 90 °C. For spectrophotometric method the derivatives of atorvastatin and fluvastatin were measured at wavelengths, 301 and 303 nm, respectively. The developed method was applied to analyze the atorvastatin and fluvastatin contents in tablets. [Pg.388]

Atorvastatin, structure of, 105. 516 ATP (see Adenosine triphosphate) ATZ, see Anilinothiazolinone, 1031-1032 Aufbau principle. 6 Axial bonds (cyclohexane), 119 drawing, 120 Azide, amines from, 929 reduction of, 929 Azide synthesis, 929 Azo compound, 944 synthesis of, 944-945 uses of. 945... [Pg.1287]

There are currently marketed four naturally derived statins (lovastatin, pravastatin, simvastatin, and rosuvas-tatin) and two synthetic statins (atorvastatin and fluvas-tatin). The structure of these statins is shown in Fig. 2. [Pg.596]

Discuss the important points to include in a teaching plan for a patient who is prescribed atorvastatin (Lipitor). [Pg.416]

C5H12O2 77-76-9) see Atorvastatin calcium Dibekacin Docetaxel Doxifluridine Epirubicin Indinavir sulfate lotrolan Misoprostol Oseltamivir acetonitrile... [Pg.2280]

C1H9NO 156-87-6) see Acamprosate calcium Cyclophosphamide Dexpanthenol Domperidone Gusperimus trihydrochloride Mefenorex Urapidil 7-amino-3-[(Z)-l-propenyl]-3-cephem-4-carboxylic acid (CiqHi2N203S 106447-44-3) see ci s-Cefprozil 3-aminopropionaIdehyde diethyl acetal (C7H,7N02 41365-75-7) see Atorvastatin calcium P-aminopropionic acid phosphite (C3H, N0 P) see Pamidronic acid... [Pg.2297]

C14H27NO4 125995-13-3) see Atorvastatin calcium A -/ert-butyl-2-[3(S)-ainino-2(R)-hydroxy-4-phenyl-hutyl]decahydro-(4aS,8aS)-isoquinolinc-3(S)-carbox-amide... [Pg.2318]

C41H44FN3O4) see Atorvastatin calcium [/t-(/f JJ )]-2-(4-fluorophenyl)-p,6-dibydroxy-S-(l-me-thylethyl)-3-phenyl-4-[(phenylamino)carbonylJ-lff-pyr-role-l-heptanoic acid 1,1-dimethylethyl ester (C37H43FN2O5 134395-00-9) see Atorvastatin calcium... [Pg.2387]

C4H7CIO 79-30-1) see Atorvastatin calcium Flutamide Ibopamine Mibefradil hydrochloride Ritonavir isochroman... [Pg.2403]

CgH N 3886-69-9) see Atorvastatin calcium Etomidate Neltinavir mesylate Repaglinide Tamsulosin hydrochloride (5)-a-methylbenzy lam ine... [Pg.2412]

CNNa 143-33-9) see Alclofenac Alpidem Amphetaminil Atorvastatin calcium Azatadine Calcium pantothenate Carnitine Clopidogrel hydrogensulfate Clortermine Dexrazoxane Diclofenac Diloxanide Edetic acid Epinastine hydrochloride Ethosuximide Ethotoin Fenoprofen Ibuprofen Irbesartan Ketoprofen Lonazolac Mephenytoin Mepindolol Montelukast sodium Nabilone Oxymetazoline Paramethadione Pentorex Saquinavir Suprofen Thiamphenicol Tolmetin Trimazosin Zolpidem sodium cyanoborohydride... [Pg.2441]

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... [Pg.2441]

Figure 26-1. Biosynthesis of mevalonate. HMG-CoA reductase is inhibited by atorvastatin, pravastatin, and simvastatin. The open and solid circles indicate the fate of each of the carbons in the acetyl moiety ofacetyl-CoA.

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