Atorvastatin lipitor

Lipitor (Atorvastatin) Atherosclerosis Dyslipidemia Hypercholesterolemia 3.8 1.3 1997 - UK and US Once daily... 

The recent years have seen the success of statins like Lipitor (atorvastatin) as hypolipidemic agents that help treating cardiovascular disease primarily by lowering low-density lipoproteins ( bad cholesterol ) levels. Another novel strategy is to tackle the same problem by elevating high-density lipoproteins (H D L or good cholesterol ) levels via inhibition of cholesteryl ester transfer protein (CETP). 

Lipitor (atorvastatin calcium) is a synthetic lipid-lowering drug. The chemical name for Lipitor is [R-(R, R )]-2-(4-fluorophenyl)-j3, 5-dihydroxy-5-(l-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l-heptanoic acid, calcium salt (2 1) trihydrate. The molecular weight is 1209.42. It is a white... 

An example of the value-added chain extending from commodities through fine chemicals to a pharmaceutical specialty is shown in Table 1.1. The product chosen is Pfizer s anticholesterol drug Lipitor (atorvastatin), the world s top-selling drug with sales of 12 billion in 2004. The value-added chain extends from a Ci molecule, methanol (left side of the table) all the way to a C33 molecule, atorvastatin. The structure of compound III in Table 1.1 is as follows ... 

Table 1.1 Example for the Value-Added Chain in the Chemical Industry Lipitor (Atorvastatin)... 

The blockbuster anti-cholesterol agents Lipitor (atorvastatin) and Crestors ... 

While that particular combination isn t currently on the market, one product (Caduet) combines Lipitor (atorvastatin) for cholesterol lowering and Norvasc (amlodipine) for blood pressure reduction. Caduet is available in a wide variety of dosages of both agents, allowing physicians to choose the one that would best suit a particular patient. That s much better than a fixed combination, since typically one size does not fit all. 

Lipitor atorvastatin Imossel, Lop-Dia, Loperhoe, Maalox, Maalox Anti-... 

A patient presents in yonr office with very high levels of serum cholesterol. Fie states that he has tried to follow the diet and exercise regimen yon gave him last year. You decide that this patient would benefit from a drng snch as Lipitor (atorvastatin). This class of drugs is effective in treating hypercholesterolemia because it has what effect ... 

E. The statin class of drugs—Lipitor (atorvastatin), Mevacor (lovas-tatin), and Zocor (simvastatin)—is used to treat hypercholesterolemia. This class of drugs lowers cholesterol levels by inhibiting the biosynthesis of cholesterol. Specifically, these drugs inhibit the enzyme P-hydroxy-P-methylglutaryl-CoA (HMG-CoA) reductase, which catalyzes the reaction that converts HMG-CoA to mevalonate. This is the rate-limiting step of cholesterol biosynthesis. 

You decide to treat a patient who has very high levels of serum cholesterol with the statin drug Lipitor (atorvastatin). You know that this drug acts in the metabolic pathway leading to the synthesis of cholesterol. The substrate for the enzyme inhibited by the statin drugs is which of the following ... 

Apart from cases like these, we shall look for special methods to exercise 1,3-control. The importance of 1,3-control is immediately obvious from the structure of important cholesterollowering drugs like Lipitor (atorvastatin) 185. The. vvn-l,3-diol is a challenge but might be made from the amine 186 or the nitrile 187. 

Erythropoietin has remained the best-selling human medicine for the past 3 years, followed by Lipitor (Atorvastatin), and both of these had over 12 billion in sales [20-22]. The sales of erythropoietin in Japan were over 1 billion. Tumor necrosis factor inhibitors, interferons, and insulins with, respectively, sales of 8.6 billion, 7.3 billion, and 6.5 billion in 2005 were the third, fourth, and fifth bestselling products after EPO and Lipitor (Table 1.5-8) [20-22, 24, 25]. The time taken to reach 1 billion annual sales for monoclonal antibodies has varied and was much faster for follow up and cancer products (Fig. 1.5-1). Rituxan is the leading antibody since 2003 by sales. The growth of Avastin and Erbitux has been much faster as compared to Herceptin and took only two years to reach 1 billion sales. 

Figure 1.17 Blockbuster drug Lipitor (atorvastatin), and orphan drugs Gleevec (imatinib) and Velcade (bortezomib).

An example that can provide hope to those who labor to come up with a new drug for an established target is that of Lipitor (atorvastatin. Figure 5.2). Currently the 1 prescription drug sold anywhere, with over 13 billion in annual worldwide sales," it was the fifth statin to be approved by the FDA, making it to market nine years after the first-in-class compound, Mevacor (lovastatin. Figure 5.2). At least one major study has demonstrated improved... 

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