Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Montelukast sodium

Biological target Montelukast is a 7-chloroquinolme-substituted derivative of the leukotriene D4 (LTD4) molecule and a seccaid generation antagonist at the CysLT-1 receptor for LTD4, a bronchoconstrictor mediator in allergic inflammation. [Pg.141]

Therapeutic profile The drug is used in the oral treatment of chronic, particularly nocturnal asthma. [Pg.141]

Montelukast sodium (1, 2-[l-[[(lR)-l-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulphanyhnethyl] cyclopropyl]acetic acid, sodium salt, Singulair , originator Merck Co.), a once-a-day oral antagonist of leukotriene D4 (LTD4) was selected for chnical development in 1991, and introduced in 1997 for the treatment of both adult and pediatric chronic asthma. This compound is recognized as one of the most significant advances in asthma therapy in the last 25 years [1] and is commonly used for the treatment of nocturnal asthma. [Pg.141]

Leukotriene receptor antagonists include montelukast sodium (Sngulair) and zafirlukast (Accolate). Zileuton (Zyflo) is classified as a leukotriene formation inhibitor. Additional information concerning these drags is found in the Summary Drag Table Antiasthma Drugs. [Pg.338]

C24H30O5) see lloprost 17P-benzoyloxy-3p-hydroxy-5-androstene (C2ijH3403 1175-12-8) see Mesterolone Testosterone 2-[l-(benzoyloxymethyl)cyclopropyl]acetonitrile (C13H13NO2 142148-12-7) see Montelukast sodium... [Pg.2303]

QHi5ClSi 18162-48-6) see Caldpotriol Montelukast sodium Orlistat Simvastatin Tacrolimus (S)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl 2-naph-thalenesulfonate... [Pg.2319]

C2oH fiClNO 149968-10-5) see Montelukast sodium [tx5-( )]-3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-[2-[2-(l-methyl-l-[(tetrahydro-2//-pyran-2-yl)oxy]ethyl]phenyll-ethyl]benzenemethanol methanesulfonate (ester) (CjjHjgClNOjS 162489-71-6) see Montelukast sodium (5)-a-[3-[(E)-2-(7-chloro-2-quinolinyI)ethenyl]phenyl]-2-(l-hydroxy-l-methylethyl)benzenepropanol (C2i,H2xClN02) see Montelukast sodium (5)-a-[3-[( )-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(l-hydroxy-l-methylethyl)benzenepropanol methanesulfonate... [Pg.2336]

C5HRO 110-87-2) see Dinoprost Dolasetron mesilate Flomoxef Iloprost Misoprostol Montelukast sodium Orlistat Pirarubicin Saquinavir... [Pg.2356]

S,7-dioxa-6-thiaspiro[2.5]octane 6-oxide (C HgOgS 89729-09-9) see Montelukast sodium... [Pg.2367]

C2jH3 07 67212-74-2) see Alclometasone dipropionate 2 -hydroxy-4 -(3-methyl-2-butenyloxy)acetophenone (C,3H] 03 24672-83-1) see Sofalcone 2-hydroxy-2-methylbutyric acid ethyl ester (C7H14O3 77-70-3) see Paramethadione 2-hydroxy-2-methylbutyronitrile (Ci H NO 4111-08-4) see Paramethadione 5(R)-(hydroxymethyl)-2-cyclopenten-l(R)-ol (C(jH,(,02 143395-28-2) see Abacavir 2-[l-(hydroxymethyl)cyclopropyl]acctonitrile (QH9NO 152922-71-9) see Montelukast sodium ( )-cis-2-hydroxymethyl-Af,Af-diethyl-l-phenylcyclo-propanecarboxamide... [Pg.2397]

CgH 02 626-19-7) see Montelukast sodium isophthaloyl chloride (C8H4CI2O2, 99-63-8) see Ditophal isophytol... [Pg.2403]

CNNa 143-33-9) see Alclofenac Alpidem Amphetaminil Atorvastatin calcium Azatadine Calcium pantothenate Carnitine Clopidogrel hydrogensulfate Clortermine Dexrazoxane Diclofenac Diloxanide Edetic acid Epinastine hydrochloride Ethosuximide Ethotoin Fenoprofen Ibuprofen Irbesartan Ketoprofen Lonazolac Mephenytoin Mepindolol Montelukast sodium Nabilone Oxymetazoline Paramethadione Pentorex Saquinavir Suprofen Thiamphenicol Tolmetin Trimazosin Zolpidem sodium cyanoborohydride... [Pg.2441]

Montelukast sodium Antiasthmatic (leukotriene receptor antagonist)... [Pg.461]

Singulair Montelukast sodium Merck Oral granules Granule... [Pg.326]

There is also continuous interaction throughout the review process. For example, over roughly six years, the sponsor, Merck Research Laboratories of West Point, Pa., and the FDA had several face-to-face meetings and about 28 teleconferences regarding the asthma drug Singulair (montelukast sodium). [Pg.245]

USAN- Montelukast sodium Trade Name Singulair Merck... [Pg.201]

Montelukast sodium (3) has the (R) absolute configuration and its synthesis was first descnbed by Labelle et The synthesis of the side-chain commenced with... [Pg.210]

Synthesis of fluticasone propionate 14.3 Synthesis of salmeterol xinafoate 14.4 Synthesis of montelukast sodium 14.5 References... [Pg.230]

See other pages where Montelukast sodium is mentioned: [Pg.1359]    [Pg.1360]    [Pg.1361]    [Pg.1362]    [Pg.2280]    [Pg.2302]    [Pg.2322]    [Pg.2327]    [Pg.2336]    [Pg.2336]    [Pg.2336]    [Pg.2336]    [Pg.2341]    [Pg.2341]    [Pg.2351]    [Pg.2406]    [Pg.2406]    [Pg.2413]    [Pg.2414]    [Pg.2414]    [Pg.2414]    [Pg.2417]    [Pg.2418]    [Pg.593]    [Pg.602]    [Pg.594]    [Pg.604]    [Pg.73]    [Pg.816]    [Pg.822]    [Pg.623]    [Pg.203]    [Pg.210]    [Pg.211]    [Pg.232]   
See also in sourсe #XX -- [ Pg.822 ]

See also in sourсe #XX -- [ Pg.1359 ]

See also in sourсe #XX -- [ Pg.173 ]

See also in sourсe #XX -- [ Pg.476 ]

See also in sourсe #XX -- [ Pg.223 , Pg.226 , Pg.476 ]

See also in sourсe #XX -- [ Pg.468 ]

See also in sourсe #XX -- [ Pg.80 ]

See also in sourсe #XX -- [ Pg.141 ]



SEARCH



Montelukast

Singulair - Montelukast sodium

© 2024 chempedia.info