Atorvastatin acid

Ten healthy subjects were given itraconazole 200 mg daily for 5 days with a single 40-mg dose of atorvastatin on day 4. The itraconazole increased the AUC of atorvastatin acid and atorvastatin lactone fourfold and threefold, respectively, and increased their half-lives threefold and twofold, respectively. The AUC values of active and total HMG-CoA reductase inhibitors were increased 1.6- and 1.7-fold, respectively. In a similar study the same dose of itraconazole increased the AUC of atorvastatin by 2.5-fold and of atorvastatin lactone by about threefold. Another study has also shown that itraconazole raises atorvastatin levels. ... 

Atorvastatin acid Cyclosporine 1431.3 Glyburide (glibenclamide) Clarithromycin 33.1... 

C1H9NO 156-87-6) see Acamprosate calcium Cyclophosphamide Dexpanthenol Domperidone Gusperimus trihydrochloride Mefenorex Urapidil 7-amino-3-[(Z)-l-propenyl]-3-cephem-4-carboxylic acid (CiqHi2N203S 106447-44-3) see ci s-Cefprozil 3-aminopropionaIdehyde diethyl acetal (C7H,7N02 41365-75-7) see Atorvastatin calcium P-aminopropionic acid phosphite (C3H, N0 P) see Pamidronic acid... 

C41H44FN3O4) see Atorvastatin calcium [/t-(/f JJ )]-2-(4-fluorophenyl)-p,6-dibydroxy-S-(l-me-thylethyl)-3-phenyl-4-[(phenylamino)carbonylJ-lff-pyr-role-l-heptanoic acid 1,1-dimethylethyl ester (C37H43FN2O5 134395-00-9) see Atorvastatin calcium... 

CNNa 143-33-9) see Alclofenac Alpidem Amphetaminil Atorvastatin calcium Azatadine Calcium pantothenate Carnitine Clopidogrel hydrogensulfate Clortermine Dexrazoxane Diclofenac Diloxanide Edetic acid Epinastine hydrochloride Ethosuximide Ethotoin Fenoprofen Ibuprofen Irbesartan Ketoprofen Lonazolac Mephenytoin Mepindolol Montelukast sodium Nabilone Oxymetazoline Paramethadione Pentorex Saquinavir Suprofen Thiamphenicol Tolmetin Trimazosin Zolpidem sodium cyanoborohydride... 

Wu, X., L. R. Whitfield, and B. H. Stewart. Atorvastatin transport in the Caco-2 cell model contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter. Pharm. Res. 2000, 17, 209-215. 

Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T (2004) Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res 21 1686-91. 

Lipitor (atorvastatin calcium) is a synthetic lipid-lowering drug. The chemical name for Lipitor is [R-(R, R )]-2-(4-fluorophenyl)-j3, 5-dihydroxy-5-(l-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l-heptanoic acid, calcium salt (2 1) trihydrate. The molecular weight is 1209.42. It is a white... 

Atorvastatin, an antihypercholesterolemic agent, is a synthetic drug that was initially produced in kilogram quantities using an 11-step chemical route. The iy -l,3-diol-con-taining side chain was produced from the chiral starting material, isoascorbic acid (Scheme 1.25). ... 

The statins, lovastatin (L), simvastatin (S), pravastatin (P), fluvastatin (F), cerivastatin, and atorvastatin, inhibit HMG CoA reductase. The active group of L, S, P, and F (or their metabolites) resembles that of the physiological substrate of the enzyme (A). L and S are lactones that are rapidly absorbed by the enteral route, subjected to extensive first-pass extraction in the liver, and there hydrolyzed into active metabolites. P and F represent the active form and, as acids, are actively transported by a specific anion carrier that moves bile acids from blood into liver and also mediates the selective hepatic uptake of the mycotoxin, amanitin (A), Atorvastatin has the longest duration of action. 

Concomitant lipid-lowering f/ erapy-Atorvastatin may be used in combination with a bile-acid-binding resin for additive effect. Generally, avoid the combination of HMG-CoA reductase inhibitors and fibrates. 

Secondary uric acid-lowering drugs such as feno-fibrate, atorvastatin and losartan all are mild-to-moderate uricosurics. 

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