Atorvastatin intermediate

The cholesterol-lowering drug atorvastatin, marketed as Lipitor, is an example where biocatalysis research has been applied extensively and is in industrial use. The enzyme 2-deoxyribose-5-phosphate aldolase (DERA) has been a target of directed evolution for the production of atorvastatin intermediates [8,9,71]. DeSantis and coworkers [8,9] used structure-based... [Pg.73]

Scheme 12. Nitrilase-catalyzed synthesis of atorvastatin intermediate by directed evolution...

Since 2000, atorvastatin (1) has been the world s top selling prescription drug, with sales in the 12 months to June 2008 of 13.8 billion [4]. The conversion of the chloro alcohol 2 to the key atorvastatin intermediate hydroxy nitrile 3 (Scheme 11.1) provides a good case history for the development of a continuous process, as it demonstrates... [Pg.223]

Patel JM (2009) Biocatalytic synthesis of atorvastatin intermediates. J Mol Catal B Enzym 61 123-128... [Pg.36]

Comoarison of Chemical Process to CRED-Catalvzed Production of Atorvastatin Intermediate 6 ... [Pg.155]

S.K. Ma, 1. Cruber, C. Davis, L. Newman, D. Gray, A. Wang, 1. Grate, G.W. Huisman, R.A. Sheldon, A green-by-design biocatalytic process for atorvastatin intermediate. Green Chem. 12 (2010) 81-86. [Pg.182]

Multigram Synthesis of an Atorvastatin Intermediate 48 Using a Mutant Halohydrin Dehalogenase... [Pg.271]

Multigram synthesis of an atorvastatin intermediate 48 using a mutant halohydrin dehalogenase [81]. [Pg.271]

A two-step three-enzyme process for atorvastatin intermediate. [Pg.9]

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