Atmospheric pressure chemical ionization tandem mass

An on-line chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI/MS/MS) methods was developed for rapid screen of pharmacokinetics of different drugs, including 5 (98RCM1216). The electron impact mass spectrum of 5 and ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7Ff-pyrido[l,2,3- fe]-l,4-benzoxazine-6-carboxylate was reported (97MI28). Electron impact/Fourier transform... [Pg.268]

Homish, R. E. and Wiest, J. R., Quantitation of spectinomycin residues in bovine tissues by ion-exchange high-performance liquid chromatography with post-column derivatization and confirmation by reversed-phase high performance chromatography-atmospheric pressure chemical ionization tandem mass spectrometry, /. Chromatogr. A, 812, 123, 1998. [Pg.312]

G. A. van der Doelen, K. J. van den Berg, J. J. Boon, N. Shibayama, E. R. de la Rie, W. J. L. Genuit, Analysis of fresh triterpenoid resins and aged triterpenoid varnishes by high performance liquid chromatography atmospheric pressure chemical ionization (tandem) mass spectrometry, J. Chromatogr., A, 809, 21 37 (1998). [Pg.235]

Beaudry F. et al., 1998. In vivo pharmacokinetic screening in cassette dosing experiments Use of online Pros-pekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery. Rapid Commun Mass Spectrom 12 1216. [Pg.293]

Bourgogne E., Grivet C., and Hopfgartner G., 2005. Determination of talinolol in human plasma using automated online solid phase extraction combined with atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B 820 103. [Pg.293]

The concentration of Sudan I, l-phenylazo-2-naphtalenol, added illegally to foodstuffs has been determined by atmospheric pressure chemical ionization tandem mass... [Pg.399]

L. Di Donna, L. Maiuolo, F. Mazzotti, D. De Luca and G. Sindona, Assay of Sudan I contamination of foodstuffs by atmospheric pressure chemical ionization tandem mass spectrometry and isotope dilution. Anal. Chem., 76 (2004) 5104-5108. [Pg.566]

Ramos, L. et al., Liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometry enantiomeric separation of DL-fhreo-methylphenidate (Ritalin ) using a macrocyclic antibiotic as the chiral selector. Rapid Commun. Mass Spectrom., 13, 2054, 1999. [Pg.167]

Moody DR, Laycock JD, Huang W, Foltz RL. 2004. A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyr-isperidone in human plasma. J Anal Toxicol 28 494. [Pg.173]

X. Xu, A.M. van der Craats, E.M. Kok and P.C.A.M. de Bruyn, Trace analysis of peroxide explosives by high performance liquid chromatography — atmospheric pressure chemical ionization — tandem mass spectrometry (HPLC-APCl-MS/MS) for forensic applications ,... [Pg.243]

C. Nomeir, A. A. Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes. Rapid Commun Mass Spectrom 2000, 14, 207-214. [Pg.423]

Fredline VF, Taylor PJ, Dodds HM, Johnson AG (1997) A reference method for the analysis of aldosterone in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Anal Biochem 252 308-313... [Pg.601]

AC Hogenboom, J Slobodnik, JJ Vreuls, JA Rontree, BLM van Baar, WMA Niessen, UAT Brink-man. Single short-column liquid chromatography with atmospheric pressure chemical-ionization-(tandem)-mass-spectrometric detection for trace enviromnental analysis. Chromatographia 42 506-514, 1996. [Pg.760]

Simultaneous Quantification of Flunitrazepam (Rohypnol) and its Major Metabolites in Human Plasma by Solid Phase Extraction and High-Performance Liquid Chromatography Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry, Using Deuterium Labeled Flunitrazepam as Internal Standard... [Pg.618]

Hao, Z. Parker, B. Knapp, M. Yu, L. 2005. Simultaneous quantification of a-tocopherol and four major carotenoids in botanical materials by normal phase liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. J. Chromatogr. A. 1094 83-90. [Pg.381]

Beaudry, E LeBlanc, J.Y.C. Coutu, M. Brown, N. In Vivo Pharmcokinetic Screening in Cassette Dosing Experiments The Use of On-Line Prospekt Liquid Chromatography/Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry Technology in Drug Discovery, Rapid Commun. Mass Spectrom. 12, 1216-1222 (1998). [Pg.352]

Kuuranne, T, Vahermo, M., Leinonen, A. and Kostiainen, R. (2000). Electrospray and atmospheric pressure chemical ionization tandem mass spechometric behavior of eight anabolic steroid gluciir-onides. J. Am. Soc. Mass Spectrom., 11, 722-730. [Pg.30]

Wu, J. et al., High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry, Anal. Chem., 79, 4657, 2007. [Pg.121]

Thomas, D., S.M. Crain, P.G. Sim, and F.M. Benoit. 1995. Application of reversed phase liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry to the determination of polycyclic aromatic sulfur heterocycles in environmental samples. J. Mass Spectrom. 30 1034—1040. [Pg.115]

Hoberg AM, Otteneder M, Mamett LJ, Poulsen HE. Measurement of the malondial-dehyde-2 -deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. J Mass Spectrom 2004 39 38-42. [Pg.676]