Liver, in vivo

Nelson MA, Bull RJ. 1988. Induction of strand breaks in DNA by trichloroethylene and metabolites in rat and mouse liver in vivo. Toxicol Appl Pharmacol 94 45-54. 

Jaeschke, H., Farhood, A. and Smith, C.W. (1990). Neutrophils contribute to ischaemia/reperfusion injury in rat liver in vivo. FASEB J. 4, 3355-3359. 

Reynolds, E.S. (1967). Liver parenchymal cell injury IV Pattern of incorporation of carbon and chlorine atoms from carbon tetrachloride into chemical constituents of liver in vivo. J. Pharmacol. Exp. Therap. 155, 117-126. 

Tates, A.D.,Neuteboom, I., Hofker, M. and den Engelese, L. (1980). A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutation Res. 74 11-20. 

Mulder GJ, Scholtens E. 1977. Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and in vitro. Biochem J 165 553-559. 

Benedetti, A., PompeUa, A., Fulceii, R., Romani, A., Comporti, M., 1986,4-Hydroxynonenal and other aldehydes produced in the liver in vivo after bromobenzene intoxication,... 

Reynolds ES, Yee AG. 1967. Liver parenchymal cell injury. V. Relationships between patterns of chloromethane-C14 incorporation into constituents of liver in vivo and cellular injury. Lab Invest 16 591-603. 

Parkki MG, Marniemi J, Vainio H Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo. Toxicol Appl Pharmacol 38 59-70, 1976... 

A. D. Cherrington (1999). Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 48 1198. 

DNA single-strand breaks, Fischer 344 rat liver in vivo... 

Gene mutation, lad transgenie C57BL/6 mouse liver in vivo Mieronueleus formation, miee in vivo... 

In the single study with mono(2-ethylhexyl) phthalate, DNA strand breaks were not induced in rat liver in vivo. 

Binding (covalent) to DNA, female NMRl mouse liver in vivo - 1100-1440 pox r Daniken et al. (1984)... 

Marked species differences in hepatic peroxisome proliferation have been reported (Ashby et al, 1994 lARC, 1995 Lake, 1995a,b Cattley et al, 1998). No study has yet compared the responsiveness of human versus rodent livers in vivo or hepatocytes in vitro to cinnamyl anthranilate however, a growing body of evidence concerning the molecular basis of peroxisome proliferation indicates that human livers and hepatocytes would be refractory to induction of peroxisome proliferation by cinnamyl anthranilate (Doull et al., 1999). 

DNA repair) in male Swiss albino mouse liver, lung and kidney in vivo DNA single-strand breaks, Sprague-Dawley rat liver in vivo DNA single-strand breaks, male Wistar rat liver in vivo... 

The asialoglycoprotein receptor has been widely used because it is a part of the surveillance system in the circulation and it removes proteins as they age by the spontaneous loss of sialic acid (212, 213). This hepatic receptor has been widely used (214) to deliver reporter genes to the rat liver in vivo. In a study, a ligand for the asialoglycoprotein receptor (ASOR) was covalently linked to poly(L-lysine). After hepatic uptake of the complex of DNA and the ASOR-poly (L-lysine) conjugate, the reporter gene product is found in the liver (214). Other examples of receptor-mediated... 

In addition, we can look forward to refinements in the means to extrapolate from cDNA-expressed enzymes to the balance of enzyme present in human liver in vivo. The examples developed in this chapter were all based on toxicological endpoints using data sets which had previously been published. While this approach shows considerable promise, clearly more extensive validation of the approach, using drugs and drug candidates, is in order. Cyclophosphamide and ifosphamide are two good candidate drugs because of the multiplicity of enzymes which metabolize these compounds. 

Conjugation of epoxybutene with GSH in the liver in vivo was demonstrated by Sharer and Elfarra (1992) in male Sprague-Dawley rats which excreted 5 -(2-hydroxy-3-... 

BVD, Binding to DNA at N7 of guanine, male Wistar rat liver in vivo NG Bolt Jelitto (1996)... 

DVA, DNA-protein cross-links, B6C31 /CrlBK mouse liver in vivo 4000 ppm inh 6 h/d. Casanova et al. 

DNA single-strand breaks, B6C31 mouse liver in vivo + 4831 ppm inh 6 h Graves et al. 

---