Mutagenicity arsenic

Schaumloeeel N and GebelT (1998) Heterogeneity of the DNA damage provoked by antimony and arsenic. Mutagen 13 281—286. 

Deknudt, G., A. Leonard, J. Arany, G.J. Du Buisson, and E. Delavignette. 1986. In vivo studies in male mice on the mutagenic effects of inorganic arsenic. Mutagenesis 1 33-34. 

In genotoxic assays inorganic arsenicals are either inactive or weak mutagens but are able to produce chromosomal effects including aberrations and sister chromatid exchange in most test systems. Studies of exposed human have detected higher incidences of chromosomal aberrations in peripheral lymphocytes and increases in the frequency of micronuclei in the oral mucosa cells, urothelial cells, and peripheral blood lymphocytes. ... 

U.S. Army Biomedical Laboratory. Evaluation of EA 4923 for mutagenicity and chromosome damaging potential. IN EA 4923 - A volatile Sensory Irritant, Part 2 - Source Documents. Edgewood Arsenal, Md. November 8, 1977. p. 217-223. 

Genetic and Neonatal Toxicity. The ability of heavy metals readily to cross the placenta and disrupt nucleic acids coupled with the high sensitivity of the fetus and neonate increases the potential dangers of congenital and neonatal toxicity. In mammalian leukocyte cultures, chromosomal aberrations have been reported with lead (112), arsenic (113), mercury (114), and methylmercury (115). Charbonneau, et al. (116) reported a lack of mutagenic effect for methylmercury. 

Hei, T.K., Liu, S.U.X. and Waldren, C. (1998) Mutagenicity of arsenic in mammalian cells role of reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America, 95(14), 8103-7. 

Okui, T. and Fujiwara, Y. (1986) Inhibition of human excision DNA repair by inorganic arsenic and the co-mutagenic effect in V79 Chinese hamster cells. Mutation Research, 172(1), 69-76. 

K. Harrington-Brock, T.W. Smith, C.L. Doerr, and M.M. Moore, Mutagenicity of the human carcinogen arsenic and its methylated metabolites, monomethylarsenic... 

Fishbein L. 1984. Overview of analysis of carcinogenic and/or mutagenic metals in biological and environmental samples I. Arsenic, beryllium, cadmium, chromium and selenium. Int J Environ Anal Chem 17 113-170. 

Lofroth G, Ames BN. 1977. Mutagenicity of inorganic compounds in Salmonella typhimurium arsenic, chromium and selenium. Mutat Res 53 65-66. 

Brown, J., Kitchin, K., George, M. Dimethylarsinic acid treatment alters six different rat biochemical parameters relevance to arsenic carcinogenesis. Teratog. Carcinog. Mutagen. 17, 71-84 (1997)... 

Arsenical Compound suspected Oncogenicity Mutagenicity Teratogenicity... 

A large amount of data has been obtained from examinations of the modifying effect of metals and metal compounds on the mutagenic action of physical and chemical agents (Table 9.4). Most of these findings are certainly attributable to one or more of the mechanisms presented above. Arsenic which per se is toxic rather than mutagenic. 

Gebel T (1998) Suppression of arsenic-induced chromosome mutagenicity by antimony. Mutat Res 412 213-218. 

Haetmann A and Speit G (1996) Effect of arsenic and cadmium on the persistence of mutagen-induced DNA-lesions in human cells. Environ Mol Mutagen 27 98-104. 

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