Carcinogenesis antioxidants

Shibata, M.A., Yamada, M., Hirose, M., Asakawa, E., Tatematsu, M. Ito, N. (1990b) Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants. Carcinogenesis, 11, 425-429... 

Animal studies have shown that teas are effective in blocking or slowing carcinogenesis (121,131,133). Administration of teas or tea polyphenols to mice or rats have also been shown to decrease oxidative biomarkers, suggesting that tea polyphenols act as antioxidants (125,134). 

In addition, there is now epidemiological evidence that dietary antioxidants, such as vitamins A, C, D and E, phytic acid, and protease inhibitors can prevent carcinogenesis, including that of the gastrointestinal (GI) tract (Graf and Eaton, 1990 Block, 1991 Malone, 1991 Troll, 1991 Weisburger, 1991). 

The consumption of a mixture of phenolic compounds presented in apple or purple grape juice inhibited mammary carcinogenesis in 7,12-dimethylbenzo[a]anthracene (DMBA) treated rats (Liu and others 2005 Jung and others 2006). However, the individual antioxidants of these foods studied in clinical trials, including (3-carotene, vitamin C, and vitamin E, do not appear to have consistent preventive effects comparable to the observed health benefits of diets rich in fruits and vegetables, suggesting that natural phytochemicals in fresh fruits and vegetables could be more effective than a dietary supplement. 

Garcia-Solis P, Yahia EM and Aceves C. 2008. Study of the effect of Ataulfo mango (Mangifera indica L) intake on mammary carcinogenesis and antioxidant capacity in plasma of /V-methyl-nitrosourea (MNU)-treated rats. Food Chem 111 309—315. 

Arivazhagan S, Velmurugan B, Bhuvaneswari V and Nagini S. 2004. Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. J Med Food 7(3) 334—339. 

Kurata, Y, Fukushima, S., Hasegawa, R., Hirose. M.. Shibata, M.-A., Shirai, T. Ito, N. (1990) Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. Jpn. J. Cancer Res., 81, 754-759... 

Chlorogenic and caffeic acids may play a role in the body s defense against carcinogenesis and mutagenesis by their antioxidant properties. The antioxidant and antiradical influences of chlorogenic acids on lipid peroxidation are not yet clear. Research has indicated that chlorogenic acids are an antioxidant, however, their complex antioxidant properties require systematic investigation in diverse directions. 

Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 92 33-38. 

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