Carcinogenesis antioxidant role

Bartsch, H., Nair, J., and Owen, R.W., Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis potential role of lipid peroxidation, dietary fat and antioxidants, Biol Chem., 383,915-921,2002. 

Bartsch, H., J. Nair, and R.W. Owen. Exocyclic DNA Adducts as Oxidative Stress Markers in Colon Carcinogenesis Potential Role of Lipid Peroxidation, Dietary Fat and Antioxidants. Biol Chem. 383 915-921 (2002). 

Chlorogenic and caffeic acids may play a role in the body s defense against carcinogenesis and mutagenesis by their antioxidant properties. The antioxidant and antiradical influences of chlorogenic acids on lipid peroxidation are not yet clear. Research has indicated that chlorogenic acids are an antioxidant, however, their complex antioxidant properties require systematic investigation in diverse directions. 

Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 92 33-38. 

Liotti FS, Bodo M, Mariucci G, et al. 1989. The role of antioxidant enzymes in benzo(a)pyrene-induced carcinogenesis. Bull Cancer 76(1 ) 43-50. 

Cerutti, P., Ghosh, R., Oya, Y., and Amstad, P. (1994). The role of the cellular antioxidant defense in oxidant carcinogenesis. Environ Health Perspect 102(Suppl 10), 123-129. 

A number of reports have stressed the importance of antioxidants in protecting cells from free radical damage, the kind that can lead to an array of degenerative diseases, including cancer.319320 Therefore, it is appropriate to mention that a number of tryptophan metabolites have been reported to have antioxidant activities.321 Under certain conditions, such effects may play a role in relation to tryptophan and its preventative effect in carcinogenesis. 

Due to the ability of most biological antioxidants to act as prooxidants at low concentrations (308), a benehcial role of dietary antioxidants as protective measures against Cr(Vl) induced carcinogenesis is being debated thus, recent data suggest that A -acetylcysteine may offer better protection than ascorbate (309, 310). 

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