Anticholinergics scopolamine

Bartus RT, Johnson HR. (1976). Short-term memory in the rhesus monkey disruption from the anticholinergic scopolamine. Pharmacol Biochem Behav. 5(1) 39-46. 

The female client tells the clinic nurse that she gets carsick every time the family goes on a vacation and the health-care provider prescribed the anticholinergic scopolamine (Transderm Scop). Which statement indicates the client understands the medication teaching ... 

Gastrointestinal Anticholinergic Combinations Antrocol Elixir—atropine sulfate, phenobarbital, alcohol Barbidonna—atropine, scopolamine HBr, hyoseyamine sulfate, phenobarbital... 

Potential oscillation was measured in the presence of cholinergic agents (acetylcholine chloride, carbamylcholine chloride, carbamyl- d-methylcholine chloride, and acetyl-/6-methylcholine chloride) and anticholinergic agents (tetramethylammonium chloride, tetra-ethylammonium chloride, succinylcholine chloride, hexamethonium chloride, scopolamine hydrobromide, atropine sulfate, homatropine hydrochloride, and tubocurarine chloride)... 

Scopolamine doses An anticholinergic that induces mental clouding or twilight sleep at high doses. 

Anticholinergic Drugs that block acetylcholine receptors, although the term is used specifically for antagonists at muscarinic acetylcholine receptors (anti-muscarinics), like atropine and scopolamine. 

Anticholinergics are rarely used. One wonders why they are used at all, for in most cases, the experience is unpleasant or frightening. Still, stories are told of people who separate scopolamine and other anticholinergics from cold remedies, or people who use jimson weed, and of those who abuse prescription anticholinergics, such as amitryptyline, trihexyphenidyl, or benztropine mesylate. One can only assume that for some people, any alteration of consciousness, even though it may not be pleasant, is desirable. 

As discussed, PCP, ditran, and scopolamine exert anticholinergic action. This property apparently is not linked to the hallucinogenic action of these molecules, however, since other hallucinogens, such as LSD and mescaline, do not affect cholinergic systems in doses sufficient to provoke hallucinatory-like behaviors in animals (67). Nevertheless, Revuelta et al. (96) noted a decreased turnover... 

Holland MS. (1992). Central anticholinergic syndrome in a pediatric patient following transdermal scopolamine patch placement. Nurse Anesth. 3(3) 121-24. 

Synthesis of scopolamine (Fig. 4), a tropane alkaloid of known anticholinergic properties, was induced hy fivefold in hairy root cultures of Atropa belladonna overexpressing hyoscianine 6[3-hydroxilase. ... 

Adult rats investigate a juvenile rat they have encountered 30 minutes before much less than a completely new individual. This recognition memory lasts about 80 minutes and is termed a transient memory. The anticholinergic drug scopolamine (hyosine) abolishes the decrease of investigation during the second encounter. It was postulated that scopolamine disturbs chemosensory receptivity in rats (Soffie and Lamberty, 1988). 

A. Alkaloids 1. Belladonna-type solanaceous tropane alkaloids [Atropine (1), (—)-Hyoscyamine (2), Scopolamine ((—)-Hysoscine)(3)] Atropa belladonna L. (belladonna), Datura metel L., D. stramonium L. (jimson weed), Hyoscyamus niger L. (henbane), Mandragora officinarum L. (European mandrake), and other solanaceous species Anticholinergics (parasympatholytics)... 

Antimuscarinic drags are classified in the following manner alkaloids (atropine, hyocyamine, scopolamine) anticholinergic of the quaternary amine series (anisotropin. 

Pharmacology The mechanism of action of scopolamine in the CNS is not definitely known but may include anticholinergic effects. The ability of scopolamine to prevent motion-induced nausea is believed to be associated with inhibition of vestibular input to the CNS, which results in inhibition of the vomiting reflex. In addition, scopolamine may have a direct action on the vomiting center within the reticular formation of the brain stem. 

Hypersensitivity Hypersensitivity to anticholinergic drugs. Patients hypersensitive to belladonna or to barbiturates may be hypersensitive to scopolamine. 

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