Transderm scop

Membrane permeation-controlled system in which the drug permeation is controlled by a polymeric membrane Transderm-Scop (scopolamine Ciba-Geigy). [Pg.522]

Meclizine (Bonine, Antivert) Scopolamine (Transderm Scop) Trimethobenzamide (Tigan)... [Pg.311]

Tramadol 66 Trandate 44 Trandolaptil 66 Transderm-nitro 52 Transderm-scop 61 Tranxene 26 Trazodone 66 Trental 55 Tretinoin 66 Tri-Levlen 82... [Pg.83]

Anergan, Phenergan) Scopolamine (Scopace, Transderm-Scop) Thiethylperazine (Torecan)... [Pg.48]

Scopolamine is useful for prevention of motion sickness when the motion is very stressful and of short duration. A transdermal preparation (Transderm-Scop) with a 72-hour duration of action has been marketed for this purpose. Blockade of chohnergic sites in the vestibular nuclei and reticular formation may account for the effectiveness of this agent. When the motion is less stressful and lasts longer, the antihistamines (Hj-antagonists) are probably preferable to the antimus-... [Pg.138]

The transdermal adhesive form of scopolamine Transderm Scop) provides up to 72 hours of antiemetic protection when applied to the postauricular area. Side effects are similar to those of oral scopolamine (see Chapter 13) but milder. [Pg.477]

Transdermal (Transderm Scop) 1.5 mg (delivers 0.5 mg/24 h) patch Solifenacin (Vesicare)... [Pg.168]

Oral 0.125, 0.15 mg tablets 0.375 mg timed release capsules 0.125 mg/5 mL oral elixir and solution Parenteral 0.5 mg/mL for injection Scopolamine (generic, Transderm Scop)... [Pg.1333]

Transderm Scop (CIBA) - Scopolamine for motion sickness effective for 3 days delivers about 5 Lig/hr. [Pg.29]

Uses antinausea drug (Transderm-Scop ) antihistamine (meth- with phenylephrine and chlorpheniramine - Extendryl , Histaspan-D )... [Pg.70]

The most popular use of scopolamine today is for the prevention of motion sickness via the Transderm-Scop patch. This device delivers about 0.5 mg of the drug over a three day period. Scopolamine and other drugs in this class can accumulate in significant quantities in the blood and some can cause CNS effects such as drowsiness, dry mouth and blurry vision. In rare cases amnesia and even psychosis can occur. The sedation and dry mouth are useful effects in that some of the compounds are used as tranquilizers and to dry up the mouth prior to anesthesia. [Pg.70]

Scopolamine Transderm-Scop, others Motion sickness, preoperative antisecretory agent, postoperative nausea and vomiting, antivertigo... [Pg.269]

Transdermal Transderm-Scop transdermal patch system Catapres-TTS transdermal system... [Pg.58]

Scopolamine was the first drug to be marketed as a transdermal delivery system (Transderm-Scop) to alleviate the discomfort of motion sickness. After oral administration, scopolamine has a short duration of action because of a high first-pass effect. In addition, several side-effects are associated with the peak plasma levels obtained. Transderm-Scop is a reservoir system that incorporates two types of release mechanims a rapid, short-term release of drag from the adhesive layer, superimposed on an essentially zero-order input profile metered by the microporous membrane separating the reservoir from the skin surface. The scopolamine patch is able to maintain plasma levels in the therapeutic window for extended periods of time, delivering 0.5 mg over 3 days with few of the side-effects associated with (for example) oral administration. [Pg.204]

Membrane-moderated patches have been utilized in many FDA-approved transdermal patches such as Duragesic, Transderm Scop, and Catapress TTS. This type of patch utilizes a rate-controlling membrane to precisely control the release of... [Pg.799]

In 1978 Tranderm Scop was the first transdermal patch to receive FDA approval. Scopolamine, the active ingredient, is a belladonna alkaloid that is frequently used to treat motion sickness and nausea resulting from anesthetics and analgesics. Transderm Scop is a membrane-moderated patch that has a three-day life span. It has a circular shape with an area (2.5 cm2) approximately the size of a quarter [26]. [Pg.800]

The practitioner should be alert to the possible inoculation into the eye of any drug or substance with anticholinergic properties, including plants, cosmetics, perfumes, or medicines. Unilateral fixed and dilated pupils have been reported after the use of antiperspi-rants, transdermal scopolamine (Transderm Scop) for the prophylaxis of motion sickness, and from direct droplet contamination associated with the use of anticholinergic aerosols for treatment of acute asthma and other airflow obstructions. [Pg.362]

Scopolamine Transderm Scop 1.5 mg in 2.5 cm 1.0 mg in 3 days Motion sickness... [Pg.455]

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