Anti-obesity effects

Han, L. K., Zheng, Y. N., Yoshikawa, M., Okuda, H., and Kimura, Y. (2005). Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement Altern. Med. 5, 9. 

It is well accepted that hyperphagia, the increased consumption of a high-fat diet and hyperinsulinemia contribute to the development of obesity. We designed two animal models of obesity gold thioglucose (GTG)-induced obesity and high-fat diet-induced obesity in mice. We examined the anti-obesity effects of natural products in these models. 

Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, Maffrand JP, Soubrie P (2003) Anti-obesity effect of SR 141716, a CBl receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 284 R345-R353... 

Zheng, G., Sayama, K., Okubo, T., Juneja, L. R., and Ognni, I. 2004. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine in mice. In Vivo 18 55-62. 

PUFA-enriched diets, particularly those containing long chain n-3 fatty acids exhibit anti-obesity effects and also improve insulin sensitivity (Li et ah,... 

Li, J. J., Huang, C. J., and Xie, D. Anti-obesity effects of conjugated linoleic acid, docosahex-aenoic acid, and eicosapentaenoic acid. Mol Nutr Pood Res 52 (2008) In press. 

It is well known that dietary fat is not absorbed from the intestine unless it has been subjected to the action of pancreatic lipase [1], Previously, we found that basic proteins such as protamines, histones and purothionine inhibited the hydrolysis of triolein emulsified with phosphatidylcholine [2], The inhibition of hydrolysis of dietary fat may cause a decrease or delay in the intestinal absorption of fat and reduce blood chylomicron levels, an excess of which is known to induce obesity [3], Therefore, there was a possibility that inhibitory substances toward pancreatic lipase activity may prevent the onset of obesity induced by feeding a high fat diet to mice. Recently, we found that natural products such as tea saponin, platycodi radix saponin, chitin-chitosan and chondroitin sulfate inhibited the pancreatic lipase activity. In the following section, the anti-obesity effects of these natural products will be described in detail. 

It was demonstrated that the anti-obesity effects of oolong tea in high-fat diet-treated mice might be partly due to the inhibitory actions of the saponin fraction in oolong tea on pancreatic lipase activity. In this study, tea saponin prevented the high-fat diet-induced increases in body and parametrial adipose tissue weights by inhibiting the intestinal absorption of dietary fat via inhibition of pancreatic lipase activity, Fig. (5). 

It was concluded that the anti-obesity effects of chitin-chitosan in high-... 

Miyashita, K. and Hosokawa, M. (2009). Anti-obesity Effect of Allenic Carotenoid, Fucoxanthin. Nutrigenomics and Proteomics in Health and Disease Impact of Food Factors-Gene Interactions. Wiley-Blackwell Publisher, Ames, lA, pp. 145-160. 

Kong, C. S., Kim, J. A., and Kim, S. K. (2009). Anti-obesity effect of sulfated glucosamine by AMPK signal pathway in 3T3-L1 adipocytes. Food Chem. Toxicol. 47, 2401-2406. 

Maeda, El., Hosokawa, M., Sashima, T., Funayama, K., and Miyashita, K. (2007a). Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin. /. Oleo Sci. 56, 615-621. 

Miyata, M., Koyama, T., Kamitani, T., Toda, T., and Yazawa, K. (2009). Anti-obesity effect on rodents of the traditional Japanese food, tororokombu, shaved Laminaria. Biosci. Biotech-nol. Biochem. 73, 2326-2328. 

Raspberry ketones prevent obesity or counteract a constitutional tendency toward obesity by promoting the decomposition of lipids accumulated in the adipose tissues. But these ketones are poorly soluble in water and have a characteristic aroma even at an extremely low concentration, so it was impossible to add an amount capable of exerting a lipolytic or anti-obese effect to cosmetics, drinks, or pet foods [29]. Flowever, by including raspberry ketones into CyDs the solubility is increased and the specific odor is reduced, resulting in a marked improvement of the taste and stabUity. Importantly, the lipolytic and anti-obese effects are not affected by the complexation. 

Miyashita, K., Tsubakihara, Y., and Alasalvar, C., Antioxidant and anti-obesity effects of hazelnnt polyphenols, presented at 6th International Conference and Exhibition on Nntracenticals and Functional Foods, Anaheim, CA, October 16-19, 2005, Abstract 28. 

Murase, T., Aoki, M., Wakisaka, T., Hase, T., and Tokimitsu, I. (2002) Anti-Obesity Effect of Dietary Diacylglycerol in C57BL/6J Mice Dietary Diacylglycerol Stimulates Intestinal Lipid Metabolism, J. Lipid Res. 43,1312-1319. 

Ohta Y, Sami M, Kanda T, Saito K, Osada K, Kato H. Gene expression analysis of the anti-obesity effect by apple polyphenols in rats fed a high fat diet or a normal diet. / Oleo Sci. 2006 55(6) 305-314. 

Hwang J-T, Kim S-H, Lee M-S et al (2007) Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun 364 1002 1008. doi 10.1016/j.bbrc.2007.10.125... 

Anti-diabetic and anti-obesity effect of OA intake has been also demonstrated by others (Kien, 2009). 

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