Anti-neutrophil cytoplasmic antibody ANCA

Akamizu T, Ozaki S, Hiratani H, Uesugi H, Sobajima J, Hataya Y, Kanamoto N, Saijo M, Hattori Y, Moriyama K, Ohmori K, Nakao K. Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA) possible involvement of complement in granulocyte cytotoxicity. Clin Exp Immunol 2002 127(l) 92-8. 

It is well recognized that antithyroid drugs, and especially propylthiouracil, can be associated with development of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis, often manifesting as renal disease. Atypical presentations, with pyoderma gangrenosum (49) and progressive bilateral sensorineural hearing loss (50), have been described in separate case reports of subjects taking propylthiouracil. 

Knowledge regarding renal injury and the development of anti-neutrophil cytoplasmic antibody (ANCA) positivity associated with silica exposure is rudimentary being hmited to epidemiological observations. Moreover, information about the health significance of the occupational exposure to other silicon containing compounds apart from silica and crystalline sihcates is lacking. 

A.J. George and C.D. Pusey, (2001). Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize re-... 

In 9 of 11 patients with silica exposure and renal involvement with systemic vasculitis, Chevalier et al. (working in Angers) found various antibodies indicative of autoimmunity, such as MPO-anti-neutrophil cytoplasmic antibodies (ANCA) and ANA at low titers, with anti-RO/Sjogren s syndrome-A in two patients, but without anti-double-stranded DNA (dsDNA) (Conrad et al. 1997). 

Immunologic A 50-year-old woman taking hydralazine for hypertension developed alveolar hemorrhage and anti-neutrophil cytoplasmic antibody (ANCA)-positive pauci-immune glomerulonephritis despite the absence of full criteria for drug-induced... 

Mulder AH, Stegeman CA, Kallenberg CG, et al. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener s granulomatosis a predominant role for the IgG3 subclass of ANCA. CUn Exp Immunol 1995 101 227-232. 

Richter C, Schnabel A, Csemok E, et al. Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vascuhtis with high-dose intravenous immunoglobulin. Chn Exp Immunol 1995 101(l) 2-7. 

Moosig E, Csernok E, Kumanovics G, et al. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). Clin Exp Immunol 2000 122 499 503. 

Urinary tract A case report was published on anti-neutrophil cytoplasmic antibody (ANCA)-positive pauci-immxme glomerulonephritis during febuxostat treatment. A 63-year-old African started treatment with febuxostat (dose not reported) because he had a history of chronic asymptomatic hyperuricemia which was not adequately controlled by allopurinol therapy. After 6 months of febuxostat therapy he developed AKI, characterised by acute renal failure, nephritic syndrome, proteinuria, microscopic haematuria and aseptic leukocyturia. Within 48 h after discontinuation of febuxostat, serum creatinine levels improved, although nephritic syndrome remained. ANCA-positive pauci-immune glomerulonephritis was confirmed by renal biopsy revealing diffuse crescentic necrotizing glomerulonephritis [60 ]. 

ABCD amphotericin B colloidal dispersion ANCA anti-neutrophil cytoplasmic antibody... 

Ig = immunoglobulins GN = glomerulonephritis, GBM = glomerular basement membrane, ANCA = anti-neutrophil cytoplasmic antibodies. Adapted from [25],... 

ANCA anti-neutrophil cytoplasmic antibodies rIFN-a recombinant interferon alpha, rIL-2 recombinant interleukin-2. 

ANAb Anti-nuclear antibodies ANCA Anti-neutrophil cytoplasmic auto antibodies cANCA Cytoplasmic ANCA pANCA Perinuclear ANCA AND Anaphylactic degranulation ANF Atrial natriuretic factor ANP Atrial natriuretic peptide Anti-I-A, Anti-I-E Antibody against class II MHC molecule encoded by I-A locus, I-E locus, anti-lg Antibody against an immunoglobulin... 

Antineutrophil cytoplasmic antibodies (ANCA) are a class of autoantibodies with varied specificities against particular proteins in the cytoplasmic granules of neutrophils and the lysosomes of monocytes. Indirect immunofluorescence microscopy and enzyme immunoassay have defined two types of ANCA patterns one causing cytoplasmic staining (C-ANCA) the other perinuclear staining (P-ANCA) [346]. Greater than 95% of C-ANCA antibiodies are anti-proteinase 3 antibodies (PR3-ANCA) and greater than 95% of P-ANCA antibiodies are anti-myeloperoxidase antibodies (MPO-ANCA) [347]. 

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