Anti-androgenic effects

A randomized, double-blind, placebo-controlled trial evaluating the use of a monophasic OC containing 30 meg ethinyl estradiol and 3 mg drospirenone, a progesterone with anti-androgenic effects, showed improvement in the treatment arm compared with placebo.31 In particular, appetite, food cravings, and acne improved. However, active treatment was not associated with a statistically significant improvement in the overall outcome measure, the Calendar of Premenstrual Experiences (COPE) scale, perhaps because of the small sample size (n = 82). 

Yamada T, Ueda S, Yoshioka K et al (2003) Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotropic and Hershberger assays. Toxicology 186 227-239... 

Anti-anaphylactic activity. Water extract of the dried fruit, at a concentration of 1 pg/ mL, produced weak activity on the rat Leuk-RBL 2H3 vs biotinyl immunoglobulin E-avidin complex-induced degranulation of (3-hexosaminidase 5 Anti-androgenic effect. Ethanol (95%) extract of the aerial parts, administered intraperitoneally to castrated mice at a dose of 2 mg/animal, produced strong activity The dried leaf, smoked by 13 male adults for 21 days, was inactive . 

Anti-androgenic effect. Sterol fraction of the dried fruit, in cell culture, was active on CA-PC3 and reduced androgen-induced reporter gene expression in transcriptional assay IC50 50 pg/mL . Administration to... 

Roxithromycin may have anti-androgenic effects. In an in vitro model roxithromycin 5 pg/ml suppressed androgen receptor transcriptional activity by 21% (1050). 

Despite its ban in the UK, residues of vinclozolin have been detected in UK-grown winter lettuce for at least six years (Table 10.6). These residues present a negligible risk to the consumer because their concentration is far too low to result in an anti-androgen effect. Nevertheless residues indicate that the pesticide has been used illegally by UK growers and therefore action must be taken. 

Although cimetidine was very effective for symptomatic treatment and permitted ulcers to heal, there were some side effects associated with its use, albeit at a very low level. In particular, there was a low incidence of gynaecomastia in men this was believed to be due to an anti-androgen effect of cimetidine seen at high doses. 

This section describes effects of exposure to PCBs on the thyroid and other non-reproductive endocrine systems. Estrogenic, anti-estrogenic, and anti-androgenic effects of PCBs are discussed in Sections 3.2.5 (Reproductive Effects), 3.5.2 (Mechanisms of Toxicity), and 3.6 (Endocrine Disruption). 

Liu, J., K. Shimizu, F. Konishi, S. Kumamoto, and R. Kondo. 2007. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Bioorg. Med. Chem. 15(14) 4966-4972. 

Phthalates differ in their ability to affect androgen pathways, with some showing anti-androgenic effects and others showing no effect (see Table 2.1). 

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