Cancer angiogenesis and

M. Klagsburn (1999). Angiogenesis and cancer, AACR special conference in cancer research. Cancer Res., 59, 487-490. 

MA M1 M01.003 Ami nopeptidase A Drug target for hypertension and angiogenesis in cancer... 

Semaphorins are secreted, membrane-associated or transmembrane proteins defined by the presence of a sema-phorin protein domain (Serna domain). In the mammalian system, more than 20 semaphorins have been identified which play important roles in a variety of tissues. The best characterized receptors for mediating semaphoiin effects are members of the neuropilin and plexin families of transmembrane proteins. Semaphoiin functions are best described in the regulation of neural development, angiogenesis, immunoregulation and cancer. 

Rempel SA, Dudas S, Ge S, Gutierrez JA (2000) Identification and localization of the cytokine SDFl and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Chn Cancer Res 6 102-111 Reya T, Morrison SJ, Clarke ME, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414 105-111... 

Stricter RM, Belperio JA, Phillips RJ, Keane MP. Chemokines angiogenesis and metastases in lung cancer. Novartis Found Symp 2004 256 173-84. 

Shellenberger TD, Wang M, Gujrati M, et al. BRAK/CXCL14 is a potent inhibitor of angiogenesis and is a chemotactic factor for immature dendritic cells. Cancer Res 2004 64 8262-8270. 

The matrix metalloprotease (MMP) family of zinc hydrolases are thought to play important roles in extracellular tissue remodeling in angiogenesis and other normal physiological processes, in some inflammatory processes and in metastatic processes in cancer. Like the zinc carboxypeptidases, the MMPs also utilize a zinc-coordinated water molecule to initiate attack on the scissile amide bond of protein substrates. These enzymes are synthesized by the ribosome in a latent form composed of a catalytic domain and an N-terminal extension, referred to as the prodomain the latent, or inactive form of the enzyme is referred to as a zymogen or... 

Folkman, J. (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-431. 

Gallo, O., Masini, E., Morbidelh, L., Eranchi, A., Eini-Storchi, 1., Vergaii, W. A., and Ziche, M., 1998, Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer, J. Natl. Cancerinst. 90 587-596. 

In agreement with the aberrant HDAC/HAT activity equilibrium in cancer, HDAC inhibitors have been shown to induce cell-cycle arrest, terminal differentiation and/or apoptosis in a broad spectrum of human tumor cell Unes in vitro, to inhibit angiogenesis and to exhibit in vivo antitumor activity in human xenograft models in nude mice [10-12]. Several HDAC inhibitors are in advanced stages of development and antitumor activity has been observed in hematological malignancies at doses that were well tolerated (Sect. 3). 

PPl (8) and its pyrazolopyrimidine analog PP2 (9) [99-108] were first described as potent inhibitors of SFKs with marked selectivity versus ZAP-70, JAK2, EGF-R, and PKA kinases. PPl provided an early key inhibitor of Src kinase to enable determination of its roles in VEGF-mediated angiogenesis and vascular permeability, Src-driven human breast cancer cell lines with respect to both heregulin-dependent or independent growth, and Src-related,... 

Eccles SA, Massey A, Raynaud El et al (2008) NVP-AUY922 a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res 68 2850-2860... 

CR Parish, C Freeman, KJ Brown, DJ Francis, WB Cowden. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 59 3433-3441, 1999. 

---