And other drugs

Chronic use of these irreversible MAO inhibitors has been associated with life-threatening toxicity, ie, hepatotoxicity and hypertensive crisis. Interactions with tyramine contained in food and other drugs have severely limited use of irreversible MAO inhibitors. These MAO inhibitors are also nonselective, inhibiting both MAO-A and MAO-B isoenzymes. Furthermore, they interfere with the hepatic metabolism of many dmgs. 

Pharmacokinetic interaction between fluoroquinolones and other drugs 98MI5. 

Analysis of alkaloids, barbiturates, and other drugs and poisons in forensic science 97AC123R. 

Burgen, A. S. V., and Spero, L. (1968). The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea-pig intestine. Br. J. Pharmacol., 34 99—115. 

Attention has to be given to the problem of interaction between azoles and other drugs these are based on two mechanisms ... 

Combinations of retinoids with ultraviolet A or B radiation (and other drugs). For example, RePUVA-therapy (retinoids and psoralen and UVA combination) is currently one of the most effective regimens for recalcitrant severe psoriasis. 

The miscellaneous drugp are used to treat a variety of musculoskeletal disorders. Ffenicillamine, methotrexate (MTX), and hydroxychloroquine are used to treat rheumatoid arthritis in patients who have had an insufficient therapeutic response to or are intolerant of other antirheumatic drugp such as the sailcylates and NSAIDs. The Summary Drug Table Drug s Used to Tream Musculoskeletal Disorders provides additional information about these and other drug s. One compound, hylan G-F 20, listed in the Summary Drug Table is not used for rheumatoid arthritis, but rather, for osteoarthritis knee pain. It is a viscous, elastic... 

Glossary—key terms and other drug-related terms are listed and defined in the back of die text... 

Interactions—more common interactions between the drag(s) discussed in tiie chapter and other drug ... 

Dantrolene should be repeated after 5—8 hr. Bicarbonate, procaine amide, and other drugs should be repeated as needed. Treatment of disseminated intravascular coagulation is symptomatic. Early diagnosis and treatment ofMH is essential. After effective treatment, the patient should be watched closely in the intensive care unit for recurrence of MH, myoglobinuric renal failure, disseminated intravascular coagulation, muscle weakness, and electrolyte imbalance. 

Regier DA, Farmer ME, Rae DS, et al Comorhidity of mental disorders with alcohol and other drug abuse results from the Epidemiologic Catchment Area (EGA) Smdy. JAMA 264 2511-2518, 1990... 

Ross HE, Frederick B, Glaser MD, et al The prevalence of psychiatric disorders in patients with alcohol and other drug problems. Arch Gen Psychiatry 45 1023-1031, 1988... 

Slater, T.F. (1968). The inhibitory effects in vitro of phenothia-zines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride. Biochem. J. 106, 155-160. 

While brain serotonin systems may play a key role in mediating some of the effects of MDMA on analgesia and body temperature as well as in the reported anxiolytic-like and mood-altering subjective effects of the drug, additional neurotransmitter systems may contribute to some of the unique subjective experiences reported for MDMA and other drugs in this class. 

This information suggests that the PCP-positive arrestee in Manhattan looks much like other drug-using arrestees. Far from being charged with assaults or bizarre types of offenses, PCP-positive arrestees are most likely to be charged with robbery, larceny, and other drug offenses. 

When finger agnosia was present, there were more errors with the nonpreferred hand (2.05 mean errors) than with the preferred hand (1.88 mean errors). Fewer than 10 percent of the sample showed performances on the hand dynamometer below the normative standards. Conversely, nearly 50 percent of the sample showed below normal performances on the finger oscillation test, a finding that suggests that fine motor dysfunction is more prevalent as a result of PCP and other drug abuse than gross motor dysfunction. 

Develop a therapeutic plan for patients with chronic asthma that maximizes patient response while minimizing adverse drug events and other drug-related problems. 

Hepatic metabolism No Yes oxidation and hydroxylation induces liver enzymes to increase its metabolism and other drugs Yes oxidation and conjugation Yes oxidation and glucuronide conjugation Yes glucuronic acid conjugation Induces its own metabolism in normal volunteers... 

A formal diagnosis of substance dependence requires a maladaptive pattern of abuse that leads to clinically significant impairment or distress. More detailed criteria revolve around the development of tolerance, the experience of withdrawal when abstinence is required, the inability to stop using the drug, and continued use over a protracted period of time. The question is whether or not these criteria, clearly applicable to cocaine, heroin, and other drugs, are met by caffeine. 

Kozlowski, L. T., Henningfield, J. E., Keenan, R. M., Lei, H., et al., Patterns of alcohol, cigarette, and caffeine and other drug use in two drug abusing populations. Special Issue Towards a broader view of recovery Integrating nicotine addiction and chemical dependency treatments. Journal of Substance Abuse Treatment, 1993 Mar-Apr Vol 10(2), 171-179, 1993. 

Y Raghunathan, L Amsel, O Hinsvark, W Bryant. Sustained-release drug delivery system I coated ion-exchange resin system for phenylpropanolamine and other drugs. J Pharm Sci 70 379-384, 1981. 

Soluble Macromolecular and Other Drug-Delivery Systems... 

At first, Sapirstein and I found the equivalence between antidepressants and other drugs puzzling, to say the least. Why should drugs that are not antidepressants be as effective as antidepressants in treating depression To answer this question, we asked another. What do all these diverse drugs have in common that they do not share with inert placebos What do SSRIs have in common with the older tricyclic antidepressants, with other less common antidepressants, and even with tranquillizers, depressants and thyroid medication The only common factor that we were able to note was that they all produce easily noticeable side effects - the one thing that was lacking in Merck s new treatment for depression. Placebos can also produce side effects, but they do so to a much lesser extent than active medication. Clinical trials show that whereas the therapeutic benefits of antidepressants are relatively small when compared to placebos, the difference in side effects is substantial.7... 

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