And liver function

More than half of the patients receiving this drug by the parenteral route experience some adverse reaction. Severe and sometimes life-threatening reactions include leukopenia (low white blood cell count), hypoglycemia (low blood sugar), thrombocytopenia (low platelet count), and hypotension (low blood pressure). Moderate or less severe reactions include changes in some laboratory tests, such as the serum creatinine and liver function tests. Other adverse reactions include anxiety, headache, hypotension, chills, nausea, and anorexia Aerosol administration may result in fatigue a metallic taste in the mouth, shortness of breath, and anorexia... 

In many individuals, hyperlipidemia has no symptoms and the disorder is not discovered until laboratory tests reveal elevated cholesterol and triglyceride levels, elevated LDL levels, and decreased HDL levels. Often, these drags are initially prescribed on an outpatient basis, but initial administration may occur in the hospitalized patient. Seram cholesterol levels (ie, a lipid profile) and liver functions tests are obtained before the drugs are administered. 

If the male or female patient is being treated for a malignancy, the nurse enters in the patient s record a general evaluation of the patient s physical and mental status. The primary health care provider may also order laboratory tests, such as serum electrolytes and liver function tests. 

Cyclosporine is a cyclic polypeptide immunosuppressant typically used to prevent organ rejection in transplant patients. Its use is restricted to patients with fulminant or refractory symptoms in patients with active IBD. Significant toxicides associated with cyclosporine are nephrotoxicity, risk of infection, seizures, hypertension, and liver function test abnormalities.1,13,14... 

When considering treatment with azathioprine or 6-MP, obtain baseline complete blood counts and liver function tests. 

In patients with a history of AED use, a baseline serum concentration may be useful to determine if the drug concentration is below the desired range and if a loading dose is needed. Albumin levels, renal function tests, and liver function tests can also be helpful when assessing antiepileptic therapy. 

Carbamazepine Manufacturer recommends CBC and platelets (and possibly reticulocyte counts and serum iron) at baseline, and that subsequent monitoring be individualized by the clinician (e.g., CBC, platelet counts, and liver function tests every 2 weeks during the first 2 months of treatment, then every 3 months if normal). Monitor more closely if patient exhibits hematologic or hepatic abnormalities or if the patient is receiving a myelotoxic drug discontinue if platelets are less than 100,000/mm3, if white blood cell (WBC) count is less than 3,000/mm3 or if there is evidence of bone marrow suppression or liver dysfunction. Serum electrolyte levels should be monitored in the elderly or those at risk for hyponatremia. Carbamazepine interferes with some pregnancy tests. 

Methotrexate Monitor complete blood cell count and liver function tests at baseline and regularly, and consider liver biopsy prior to treatment and at a cumulative dose of 1.5 g. If available, monitor PIIINP at least three times yearly. 

Acitretin Monitor serum lipids and liver function tests. 

The patient may be failing his current regimen due to nonadherence or a drug interaction with famotidine. Check HIV RNA and CD4 count to evaluate HIV treatment efficacy and complete blood count with differential, chemistry profile, and liver function tests for routine follow-up. 

Laboratory tests Complete blood count, lactate dehydrogenase (LDH), renal function, and liver function tests... 

There is no universal guideline for follow-up care for MM. The National Comprehensive Cancer Network recommends annual skin examination for all patients.61 Educate patients with stage IA disease to have a history and physical examination every 3 to 12 months as clinically indicated and an annual skin examination for life. For stage IB to III disease, schedule a history and physical examination every 3 to 6 months for 3 years, every 4 to 12 months for 2 years, and then annually as indicated. It is optional to obtain a chest x-ray, LDH, complete blood count (CBC), and liver function tests (LFTs) every 3 to 12 months. CT scan can be obtained as indicated clinically.61 For NMSC, educate patients to schedule follow-up visits with... 

In the foregoing example, the drug was administered to a healthy subject who had normal kidney and liver function. The estimated biological half-life in this... 

MacPherson, A. and R.G. Hemingway. 1969. The relative merit of various blood analyses and liver function tests in giving an early diagnosis of chronic copper poisoning in sheep. Brit. Veterin. Jour. 125 213-221. 

Cholestatic hepatitis has been reported with risperidone, and liver function test abnormalities (mostly transient) have been reported with olanzapine and clozapine. 

Dossing, M., Loft, S., and Schroeder, E., Jet fuel and liver function, Scand. J. Work Environ. Health, 11,433, 1985. 

Correlation of Vitamin B12 Excretion and Liver Function Tests 8 Hours After a 60 ig Load Dose... 

Stehr-Green PA, Wohlleb JC, Royce W, et al. 1988. An evaluation of serum pesticide residue levels and liver function in persons exposed to dairy products contaminated with heptachlor. JAMA 259(3) 374-377. 

On rare occasions, pemoline can cause a chemical hepatitis (liver dysfunction). For this reason, patients with known liver disease should not be prescribed pemoline. A baseline laboratory assessment of liver enzymes before starting therapy with pemoline is advised, and liver function monitoring must be repeated periodically. If liver abnormalities are detected, then pemoline must be discontinued. The recognition of this side effect resulting from therapy with pemoline has markedly restricted its use. 

PO loading dose 400 mg tid x 15-30 days, then 200-400 mg qd (5-10 mg/l ) pneurrwnitis when dose >400 mg/d elevation of digoxin level, prolongation of prothrombin time (70-100%) with warfarin pultrwnary fibrosis, hepatitis, ocular opacities proarrhythmic monitor thyroid and liver function... 

Adverse events should be tabulated for easy inspection but the case report form should be available and all laboratory data such as blood coimts, renal function and liver function tests should be inspected closely The absence of obvious adverse events does not mean that all is well, and careful scrutiny of data by an experienced physician can often spot problems before they become troublesome. Not infrequently one or more volunteers become imwell during the course of a study, usually due to intercurrent viral infections, and decisions about postponement of study days and subject withdrawal follow-up can be made during these meetings. Data that are missing because of non-attendance of volunteers, for whatever reason, may lead to a delay in the study, with postponement of dose escalation imtil they have caught up. 

Toxicology. All isomers of cresol cause skin and eye burns exposure also may cause impairment of kidney and liver function, as well as central nervous system and cardiovascular disturbances. 

The metabolic and clinical condition of the patient also plays a role The individual with good kidney and liver function will respond quite differently to a drug than the patient who is not able to detoxify or excrete the compound. The user of laboratory data must be aware of the possible occurrence of drug-mediated enzyme induction, biological variations in the rate of clearance and storage in depot areas (B24), and the genetic factors that play a role in the toxicity of a drug (L2). 

Drug/Lab test interactions Certain endocrine and liver function tests may be affected by estrogen-containing OCs. Expect these similar changes with larger doses Increased sulfobromophthalein retention. 

Monitoring Blood count, Coombs tests, and liver function tests are recommended before initiating therapy and at periodic intervals. Perform periodic determinations of hepatic function, particularly during the first 6 to 12 weeks of therapy or when an unexplained fever occurs. 

Monitoring Because of isolated reports of neutropenia and jaundice, perform periodic blood counts, and liver function tests during long-term therapy. 

Monitoring Perform baseline and periodic leukocyte and differential counts and liver function studies. Fever or sore throat may signal serious neutrophil depression discontinue therapy if there is evidence of pathological neutropenia. 

Monitoring Perform complete blood counts, including differential white cell count and liver function tests before starting sulfasalazine and every second week during the first 3 months of therapy. During the second 3 months, perform the same tests once monthly and, thereafter, once every 3 months and as clinically indicated. Also perform urinalysis and assess renal function periodically during treatment. 

Monitoring Perform blood cell counts and renal and liver function tests periodically if treatment is continued for more than 2 weeks. 

Monitoring Monitor patients by hematologic, renal excretion, blood level, and liver function studies. 

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