Anaphylaxis and Allergy

FIGURE 2. Post-receptor events initiated by H2- and H,-receptor activation by histamine (HIS). Adenylate cyclase (AC) stimulation occurs directly via H2-receptor activation or possibly indirectly via a calmodulin-calmodulin binding protein complex. Membrane inositol phospholipid (IPL) hydrolysis to inositol trisphosphate (IP3) is triggered by phospholipase C (PC) activation following H,-receptor stimulation. [Pg.194]

The deleterious effects of excess histamine in allergy are transiently contained [Pg.194]

Despite the fact that a number of various factors can cause the release of endogenous histamine, it is believed that the most important reason is an immunological response of the organism. Accepted knowledge states that during anaphylaxis and allergies, a specific... [Pg.219]

Histamine is released from mast cells in antigen-antibody reactions, as in anaphylaxis and allergy, which are the most widely known physiological reactions to histamine. However, these potentially fatal reactions are not caused by histamine alone. Other agents present in mast cells, such as serotonin, acetylcholine, bradykinin (a nonapeptide), and a slow-reacting substance or leukotriene (see chapter 8) also contribute. In the stomach, where histamine induces acid secretion, its release seems to be regulated by the peptide hormone pentagastrin. [Pg.261]

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Schwartz LB Diagnostic value of tryptase in anaphylaxis and mastocytosis 2. Immunol Allergy Clin North Am 2006 26 451-463. [Pg.137]

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Matheu, V., de Barrio, M., Sierra, Z., Gracia-Bara, M.T., Tomero, P., and Baeza, M.L. 1999. Lupine-induced anaphylaxis. Ann Allergy Asthma Immunol 83 406-408. [Pg.277]

SanchezBorges, M., CaprilesHulett, A., FernandezCaldas, E., SuarezChacon, R., Caballero, F., Castillo, S., and Sotillo, E. 1997. Mite-contaminated foods as a cause of anaphylaxis. J Allergy Clin Immunol 99(6) 738-743. [Pg.363]

Third, inhaleables provide for very rapid onset of action similar to the i.v. route and quicker than can be achieved with either oral delivery or subcutaneous injections. More rapid delivery could benefit treatments for pain, seizures, panic/anxiety attacks, hypertensive crises, anaphylaxis (severe allergies, food, insect bites), nausea, cardiovascular conditions (arrhythmia, strokes), and Parkinson s lock-up —indications where speed is important. [Pg.1279]

Heilborn H, Hjemdahl P, Daleskog M, Adamsson U. Comparison of subcutaneous injection and high-dose inhalation of epinephrine—implications for self-treatment to prevent anaphylaxis. J Allergy Qin Immnnol 1986 78(6) 1174-9. [Pg.43]

Dejarnatt AC, Grant JA. Basic mechanisms of anaphylaxis and anaphylactoid reactions. Immunol Allergy Clin North Am 1992 12 33-46. [Pg.498]

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