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Analytical calibrations

Figure 2.2. Examples of correlations with high and low coefficients of determination. Data were simulated for combinations of various levels of noise (a = 1,5, 25, top to bottom) and sample size (n - 10, 20, 40, left to right). The residual standard deviation follows the noise level (for example, 0.9, 5.7, 24.7, from top to bottom). Note that the coefficient 0.9990 in the top left panel is on the low side for many analytical calibrations where the points so exactly fit the theoretical line that > 0.999 even for low n and small calibration ranges. Figure 2.2. Examples of correlations with high and low coefficients of determination. Data were simulated for combinations of various levels of noise (a = 1,5, 25, top to bottom) and sample size (n - 10, 20, 40, left to right). The residual standard deviation follows the noise level (for example, 0.9, 5.7, 24.7, from top to bottom). Note that the coefficient 0.9990 in the top left panel is on the low side for many analytical calibrations where the points so exactly fit the theoretical line that > 0.999 even for low n and small calibration ranges.
VanArendonk, M. D., and Skogerboe, R. K., Correlation Coefficients for Evaluation of Analytical Calibration Curves, Anal. Chem. 53, 1981, 2349-2350. [Pg.407]

Teflon-lined screw-caps. The absolute volume of the standard solutions may be varied at the discretion of the analyst, as long as the correct proportions of the solute and solvent are maintained. The stock solutions below are adequate to prepare fortification and calibration standards in the range 0.10-20.0 pg of each analyte. Calibrate the analytical balance before weighing any neat analytical standard for this method. [Pg.382]

Alternatively, fundamental parameter methods (FPM) may be used to simulate analytical calibrations for homogeneous materials. From a theoretical point of view, there is a wide choice of equivalent fundamental algorithms for converting intensities to concentrations in quantitative XRF analysis. The fundamental parameters approach was originally proposed by Criss and Birks [239]. A number of assumptions underlie the application of theoretical methods, namely that the specimens be thick, flat and homogeneous, and that, for calibration purposes, the concentrations of all the elements in the reference material be known (having been determined by alternative methods). The classical formalism proposed by Criss and Birks [239] is equivalent to the fundamental influence coefficient formalisms (see ref. [232]). In contrast to empirical influence coefficient methods, in which the experimental intensities from reference materials are used to compute the values of the coefficients, the fundamental influence coefficient approach calculates... [Pg.632]

Table 6.1. Input quantities, qin, and output quantities, qout, in analytical calibration ... Table 6.1. Input quantities, qin, and output quantities, qout, in analytical calibration ...
In analytical calibration, there exists - strictly speaking - no correlation problem for the following two reasons ... [Pg.155]

This model usually does not have any relevance in analytical calibration. [Pg.155]

Because of the irrelevant condition sy/b s ), the reverse model, viz. the estimation of x from /, according to Eq. (6.7) and therefore the coefficients by and ay> are not of direct relevance in analytical calibration. Notwithstanding, their estimates will be given here for completion and as auxiliary quantities for further calculations ... [Pg.156]

All the special cases that may be appear in analytical calibration in dependence from the specific conditions as well as the uncertainties of the calibration measures will be given in the following. [Pg.156]

In Fig. 6.5 three different calibration functions are given. First, the model to estimate y from (practically) error-free x values. This model is commonly used for analytical calibration in form of OLS, j> = flx + bxx (Eq. 6.6). Another model (usually without relevance in analytical calibration because... [Pg.164]

Sole use of the correlation coefficient (r) alone is not recommended as a means to demonstrate linearity. The correlation coefficient describes the relation between two random parameters, and shows no relevance for the analytical calibration [31]. The correlation coefficient does not indicate the linearity or lack thereof, unless r exceeds 0.999 [8, 32, 33]. If the value of r is less than 0.999, other parameters such as Vxo, Xp value, ANOVA linear testing, etc., should be calculated. Ebel [34] described using the transformation of r (i.e., Vu ) for expressing the degree of linearity, where the acceptance value of (1 — r ) should be less than 0.05. Camag (Muttents) described the sdv parameter (i.e., the relative standard deviation of the calibration curve) for expressing the linearity of a calibration curve for TLC/HPTLC in its CATS software, and can be calculated as follows ... [Pg.251]

An ideal method for the preconcentration of trace metals from natural waters should have the following characteristics it should simultaneously allow isolation of the analyte from the matrix and yield an appropriate enrichment factor it should be a simple process, requiring the introduction of few reagents in order to minimise contamination, hence producing a low sample blank and a correspondingly lower detection limit and it should produce a final solution that is readily matrix-matched with solutions of the analytical calibration method. [Pg.303]

The first photoelectric fhiorimeter was described by Jette and West in 1928. The instrument, which used two photoemissive cells, was employed for studying the quantitative effects of electrolytes upon the fluorescence of a series of substances, including quinine sulfate [5], In 1935, Cohen provides a review of the first photoelectric fluorimeters developed until then and describes his own apparatus using a very simple scheme. With the latter he obtained a typical analytical calibration curve, thus confirming the findings of Desha [33], The sensitivity of these photoelectric instruments was limited, and as a result utilization of the photomultiplier tube, invented by Zworykin and Rajchman in 1939 [34], was an important step forward in the development of suitable and more sensitive fluorometers. The pulse fhiorimeter, which can be used for direct measurements of fluorescence decay times and polarization, was developed around 1950, and was initiated by the commercialization of an adequate photomultiplier [35]. [Pg.10]

Recovery tests or use of internal standards for pre-treatment and use of reference materials for analytical calibration and traceability [5]. [Pg.250]

Table 13.1. Some hypothetical analytical calibration data. Table 13.1. Some hypothetical analytical calibration data.
Does it decrease the reliability of the analytical calibration curve ... [Pg.622]

Figure 12.31 Illustration of a hybrid calibration strategy. (A) Scatter plot of first two PCA scores obtained from a process analytical calibration data set containing both synthesized standards (circles) and actual process samples (triangles). (B) Results of a PLS regression fit to the property of Interest, using all of the calibration samples represented In (A). Figure 12.31 Illustration of a hybrid calibration strategy. (A) Scatter plot of first two PCA scores obtained from a process analytical calibration data set containing both synthesized standards (circles) and actual process samples (triangles). (B) Results of a PLS regression fit to the property of Interest, using all of the calibration samples represented In (A).
Analyte Calibration number/[Analyte] [ISTD] ratio ... [Pg.147]

Please refer to section 3.2.4, subheadings Pre-analytical , Calibration . [Pg.197]

The parameter used in the analytical calibrations by AAS is absorbance (A), which is linearly related to k (that is, at a given 2, with the atomic concentration of the analyte in the atomiser) and with the length of the optical path ... [Pg.7]

Often the equipment used to run the analytical methods must also undergo some type of qualification. It is suggested that installation qualification activities be performed at the very least. Many laboratory methods must undergo a calibration before each use, which can serve to eliminate the need for operational and performance qualifications. Again, all of the related analytical calibration/ qualification/validation activities performed must be documented. [Pg.290]

The stability of enzyme electrodes is difficult to define because an enzyme can lose some of its activity. Deterioration of immobilized enzyme in the potentiometric electrodes can be seen by three changes in the response characteristics (a) with age the upper limit will decrease (e.g., from 10-2 to 10 3 moll-1), (b) the slope of the analytical (calibration) curve of potential vs. log [analyte] decrease from 59.2 mV per decade (Nernstian response) to lower value, and (c) the response time of the biosensor will become longer as the enzyme ages [59]. The overall lifetime of the biosensor depends on the frequency with which the biosensor is used and the stability depends on the type of entrapment used, the concentration of enzyme in the tissue or crude extract, the optimum conditions of enzyme, the leaching out of loosely bound cofactor from the active site, a cofactor that is needed for the enzymatic activity and the stability of the base sensor. [Pg.369]

Figure 8.20 Detection of a single X-sample outlier by plotting the analytical profiles of five of the calibration samples in a process analytical calibration data set. Figure 8.20 Detection of a single X-sample outlier by plotting the analytical profiles of five of the calibration samples in a process analytical calibration data set.
Figure 8.37 Scatter plot of the first two PCA scores obtained from a process analytical calibration data set containing both synthesized standards (circles) and actual process samples (triangles). Figure 8.37 Scatter plot of the first two PCA scores obtained from a process analytical calibration data set containing both synthesized standards (circles) and actual process samples (triangles).
In environmental modeling, perhaps after starting from case A, or in the extremely important analytical calibration process, case B, one prefers linear models for reasons of conceptual simplicity. [Pg.50]

Cuadros-Rodrfguez L, Bagur-Gonzalez MG, Sanchez-Vinas M, Gonzalez-Casado A, Gomez-Sdez AM (2007) Principles of analytical calibration/quantification for the separation sciences. J Chromatogr A 1158 33-46... [Pg.30]

It is important to understand the overall principles of the methods rather than rely too much on any individual piece of software or application. In fact the algorithms are straightforward and can be easily implemented computationally. For any individual instrumental technique, be it HPLC, or electrochemistry, or electronic absorption spectroscopy, and any specific application, such as process control or environmental monitoring, specific extensions are needed, and different workers from different scientific environments often assume that their own elaborations are generally transportable. This is often not the case, but a basic understanding of the methods reported in this paper provides a generic starting point for analytical calibration. [Pg.26]

Finally, consideration must be given to the availability of pure reference compounds from which to construct analytical calibration curves. Some compounds (such as phenolic acids) may be purchased commercially, but for others (such as benzoxazinoids) it will be necessary to first isolate and purify them from recognized natural sources described in the literature12 or to synthesise them.11... [Pg.165]

Now, with the advent of reference materials, the term standard is too general to be used alone and it is, therefore, normal to specify the type of standard, e.g. analytical, calibration, reference material, etc. Use of the term standard(s) is, therefore, only appropriate in the most general of contexts. [Pg.45]

An entire analytical procedure (i.e., a group of activities leading to information on either the kind or quantity of a component in the sample assayed) consists of several separate stages. If the final goal of this procedure is a quantitative result, one of the essential stages is analytical calibration. [Pg.27]

When the analytical instrument used is not able to directly produce signals for the analyte but only for a substance able to react with the analyte, calibration by the indirect method is used. The reagent is added in a constant and known amoimt to both sample and standard solutions. If it is added in excess in relation to the highest analyte concentration, the amoimt remaining after reaction decreases in successive standard solutions. The calibration graph produced is presented in Fig. 3.7. [Pg.34]

Koscielniak, P., Wieczorek, M., Kozak, J., Herman, M. Versatile flow injection manifold for analytical calibration. Anal. Chim. Acta 600, 6-13 (2007)... [Pg.48]


See other pages where Analytical calibrations is mentioned: [Pg.210]    [Pg.434]    [Pg.239]    [Pg.45]    [Pg.418]    [Pg.262]    [Pg.113]    [Pg.239]    [Pg.789]    [Pg.1]    [Pg.160]    [Pg.476]    [Pg.308]    [Pg.280]    [Pg.291]    [Pg.313]    [Pg.27]    [Pg.47]   
See also in sourсe #XX -- [ Pg.308 ]

See also in sourсe #XX -- [ Pg.268 , Pg.274 ]




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