Analysis of responses

Robinson SF, Pauly JR, Marks MJ, Collins AC (1994) An analysis of response to nicotine infusion using an automated radiotelemetry system. Psychopharmacology 115 115-120 Role LW, Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16 1077-1085... 

A seeond milestone was a letter by the PDG in May 1992 asking for further candidates, beyond excipients. Responses to that inquiry focused primarily on tests and assays. Replies were ranked by order of priority. The priority of excipients was expanded to the top 25, based upon further analysis of responses. The lists of combined assignments and priorities for pharmacopeial harmonization appeared in the forum publieations of the pharmacopeias [12,13]. 

Aishima, T. (1991) Aroma discrimination by pattern recognition analysis of responses from semiconductor gas sensor array. J. Agric. Food Chem. 39 752-756. 

Effective concentration of a test material in the test matrix (eg., growth medium) that is calculated to exhibit a specified non-lethal or lethal effect to x% of a group of test organisms during exposure over a specified period of time. The ECx and its 95% confidence limits are usually derived by statistical analysis of responses in several test concentrations. The particular effect must be specified as well as the exposure time (e.g., 48-h EC50 for immobilization). Volume 1(1,4,10). 

Figure 24.3 Temporal analysis of responses measured simultaneously in five different antennal lobe neurons in the moth Manduca sexta. The matrices show patterns of neural synchrony evoked by either of two pheromone components or a binary mixture at two concentrations. The number of synchronous events was averaged over 20 trials and calculated for 500 ms from stimulus onset. The gray scale ranges from 0 to 3.8 coincident spikes per stimulus. The horizontal displays below the matrices show the averaged spiking rate in each single neuron (gray scale ranges from 0 to 5.5 spikes per stimulus period). Neural synchrony was influenced not only by the odor quality but also by both stimulus intensity and blend interactions (redrawn from Christensen eta ., 2000).

Analysis of response in subsets of the overall population drug-demographic, drug-drug, and drug-disease interactions... 

An analysis of responses in subsets of the overall population is required. The extent of this part of the integrated summary of efficacy will depend to a large extent on the drug and its intended patient population. Subsets of interest may include sex, race, age, disease severity, concomitant illness, concomitant drugs, smoking and alcoholism, and prior therapy. 

Module 10 Post interview/post simulation interview To ascertain past history of contact with chemicals and training. To test the effect of a brief explanation of symbols, signal words, colours and hazard statements on ranking for severity of hazard, and comprehension. To identify chemical information needs from subjects. Variables derived from training and past experience for stratified analysis of responses to modules 3 to 9. Results will help to indicate whether training should be the subject of more detailed evaluation in the long term. Responses to questions on needs for chemical information can be useful to GHS efforts on chemical safety. 

Baker, W.J., 1966 The Effects of Drugs on Human Performance The Analysis of Responses Over Time In Weight-Adjusted vs. Fixed-Dose Studies of Psychoactive Chemicals. Technical Note No. 2, Contract No. 

Analysis of Variance (ANOVA) A collection of statistical procedures for analysis of responses from experiments. Single-factor ANOVA allows comparison of more than two means of populations. 

McClay JL, Adkins DE, Aberg K, Stroup S, Perkins DO, Vladimirov VI et al (2011) Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry 16 76-85... 

This is the case in canonical analysis of response surface model, where the coefficient matrix is symmetric. 

One of the major areas of research interest in wine strains of S. cerevisiae is the analysis of response to stress. This focus is motivated by both practical and fimdamental interests. The production of wine imposes both biotic and abiotic stresses on the yeast. The principal stresses encountered are high osmolarity, high ethanol, extremes of temperature, nutrient limitation, and presence of inhibitory metabolites (Bisson, 1999). Genomic analysis of the response to each of these types of stress has been conducted (Alexandre et al., 2001 Aranda and del Olmo, 2004 Backhus et al., 2001 Erasmus et al., 2003 Kuhn et al., 2001 Marks et al., 2003 Rep et al., 2000 Rossignol et al., 2006 Sahara et al., 2002). Several... 

Harrison, T.A. and Scott, J.W. (1986) Olfactory bulb responses to odor stimulation Analysis of response pattern and intensity relationships. J. Neurophysiol., 56, 1571-1589... 

This volume, the brainchild of two major figures in protein chemistry, David Eisenberg and Peter Kim, covers our current understanding of these cellular components/machines, with an emphasis on their mechanisms of action. In addition, there is a chapter on protein misfolding in prion disease in a yeast system, with some attention given to the influence of molecular chaperones on that process, and one on a system analysis of response to ER stress. 

All but two of the respondents to the Discussion Document were supportive of one or other of these two proposals. HSE concluded fiom its analysis of responses and of additional views received during its efforts to disseminate and discuss material on these issues that there was overwhelming support for a single limit system that was coupled to good advice on controlling chemicals (HSC 2003 9). 

Da Re, S., Tolstykh, T, Wolanin, P.M. and Stock, J.B. (2002). Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism. Protein Sci. 11, 2644 2654. 

Hughes, J. R. Mazurowski, J. A. Studies on the supracallosal mesial cortex of unanesthetized, conscious mammals. II. Monkey. C. Frequency analysis of responses from the olfactory bulb. Electroencephalography and Clinical Neurophy-... 

S.L. Rose-Pehrsson, J.W. Grate, D.S. BaUantine, P.C. Jurs, Detection of hazardous vapors including mixtures using pattern recognition analysis of responses from siuface acoustic wave devices. Anal. Chem. 60, 2801-2811 (1988)... 

The second most important parameter in many applications is response time. It can be limited by a variety of factors, such as carrier lifetimes within the detector material, the sweepout time of photoexcited carriers, and the RC time constant of the detector and/or its associated circuitry. Detailed analysis of response times goes beyond the scope of this chapter. 

David JP, Faucon F, Chandor-Proust A, Poupar-din R, Riaz MA, Bonin A, Navratil V, Reynaud S (2014) Comparative analysis of response to selection with three insecticides in the dengue mosquito Aedes aegypti using mRNA sequencing. BMC Genomics 15 174... 

This chapter has shown how multivariate dependent data, from multiple experiments or multiple results from one experiment, may be analysed by a variety of methods. The output from these analyses should be consistent Avith the results of the analysis of individual variables and in some circumstances may provide information that is not available from consideration of individual results. In this respect the multivariate treatment of dependent data offers the same advantages as the multivariate treatment of independent data. The simultaneous multivariate analysis of response and descriptor data may also be advantageous but does suffer from complexity in prediction. 

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