4-Amino-2-chloro-5- benzenesulfonamide

Chemical Name 2-chloro-/V-(((4-methoxy-6-methyl-l,3,5-triazin-2-yl)amino)-carbonyl)-benzenesulfonamide ... 

CDAA (N-N-diallyl-2-chloroacetamide) was reported to reduce mitosis in barley (Hordeum vulgare L.) roots nearly 90% after 96 h at 57 yM (38). Propachlor (2-chloro-N-isopropylacetanilide) totally inhibited mitosis in onion (Allium cepa L.) root tips after an 18 h treatment with 75 yM (3 ). At 20 yM cell division was reduced approximately 50% and cell enlargement was reduced 40% in oat coleoptiles (39). After 24 h, 100 yM ioxynil (4-hydroxy-3,5-diiodobenzonitrile) reduced the mitotic index in broad bean (Vicia faba L. ) and pea root tips ( ). Few herbicides that inhibit cell division have been studied in adequate detail to locate the site of the block. A notable exception is the herbicide chlorsulfuron (DPX 4189, 2-chloro-N- [(4-methoxy-6-methyl-l,3,5-triazin-2-yl)amino]carbonyl -benzenesulfonamide) ( ). Ray reported a 50% reduction in corn growth 3 h after treatment with 28 yM chlorsulfuron. Mitosis in broad bean root tips was significantly reduced by 2.8 yM, whereas in three different tests, cell enlargement was not influenced with concentrations of 28 yM. Thymidine incorporation into DNA was inhibited in corn root tips after a 1 h treatment with... 

Amino-2-chloro-5-(methylsulfamyl)benzenesulfOnamide Manufacturing Process... 

B) Preparation of 4-Amino-2-Chloro-5-(Methylsulfamyl)Benzenesulfonamide The 5-sub-stituted-2,4-dlsulfamyl anilines may be prepared by procedures described in the literature, for example, the general procedures in Monatsch. Chem. vol. 48, p 87 (1927), which involves the treatment of a m-substituted aniline with from 10 to 20 parts by weight of chlorosulfonic acid followed by the gradual addition of from about 90 to 170 parts by weight of sodium chloride. The resultant mixture is heated at approximately 150°C for about 2 hours after which the reaction mixture is poured into water and the resultant 5-substituted aniline-2,4-disulfonyl chloride is filtered and is then treated with concentrated ammonium hydroxide or suitable amine by standard procedures to obtain the corresponding disulfonamide. 

C) Preparation of 2-Methyl-3-(2,2,2-Trifluoroethyl)Thiomethyl-6-Chloro-7-Sulfamyl-3,4-Dihydro-1,2,4-Benzothiadiazine-1,1-Dioxide To 4.6 g (0.015 mol) of 4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide in 30 ml of the dimethyl ether of ethylene glycol is added 4.08 g (0.02 mol) of 2,2,2-trifluoroethylmercaptoacetaldehyde dimethylacetal followed by 1 ml of ethyl acetate saturated with hydrogen chloride gas. The resulting solution is refluxed for 1.5 hours, cooled and then slowly added to cold water dropwise with stirring. The crude product is filtered, dried and recrystallized from isopropanol (3.2 g), MP 202° to 202.5°C. A second recrystallization from isopropanol raised the MP to 202°... 

Chemical Name 4-amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide Common Name —... 

Figure 12.10 Pyrogram of acrylic emulsion paints containing different organic pigments (a) PR5 (b) PR112 (c) PR4 (d) PY3 (e) PR 251 (f) PY74. Peak assignments 1, EA 2, MMA 3, nBA 4, 4 chloro 2 nitro benzenamine 5, 2 chloro benzenamine 6, 1 chloro 2 isocya nato benzene 7, 2 methoxy 4 nitro benzenamine 8, 2 methoxy benzenamine 9, 1 isocya nato 2 methoxy benzene 10, 1 chloro 4 nitro benzenamine 11,1 chloro 2 nitro benzene 12, 2 naphthalenol 13, 3 amino 4 methoxy N,N diethyl benzenesulfonamide 14, 4 meth oxy N,N diethyl benzenesulfonamide 15, 5 chloro 2,4 demethoxy benzenamine 16, 2,4,5 trichloro benzenamine 17, 1,3,4 trichloro benzene 18, 2 methyl benzenamine 19,...

Azosemide. 2-Chloro-5-(17/-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide 615, diuretic. 

The synthesis of pazopanib (1) involves sequential animation of 2,4-dichloropyrimidine 25 with 6-amino-2,3-dimethylindazole 24 and 5-amino-2-methyl-benzenesulfonamide 28. The 6-amino-2,3-dimethylindazole 24, on the other hand, was prepared from 2-ethylphenylamine 20 via 5-nitration with fuming nitric acid and concentrated sulfuric acid, followed by treatment with isoamyl nitrite and acetic acid to produce 6-nitro-3-methylindazole 22. The 6-nitro group was reduced with stannous chloride and concentrated HC1 in glyme and subsequently methylated at the C2 position of the indazole ring with trimethyloxonium tetrafluoroborate in acetone to produce 6-amino-2,3-dimethylindazole 24. The resultant indazole 24 was condensed with 2,4-dichloropyrimidine 25 in the presence of sodium bicarbonate in ethanol/THF and subsequent iV-methylation with iodomethane and cesium carbonate to produce 27. The 2-chloro group of pyrimidine was then allowed to react with 5-amino-2-methyl-benzenesulfonamide 28 in catalytic HCl/isopropanol and heated to reflux to deliver pazopanib hydrochloride (1) in good yield. 

Sulfachlorpyridazine. 4-Amino-N-(b-chloro-3-pyridazinyt)benzenesulfonamide -V-(6-chloro-l.pyridazin-yl)sulfanilamlde 3 -ch to ro - 6 -sulf ani lam idopy r idazi ne 3 -sulfanilamido-6-chloropyridazine 3 -(p-aminophenylsulfon -... 

AI3-16452 Annogen Benzene chloramine Benzene-sulfo-sodium chloramlde Benzenesulfochloramide, N-chloro-, sodium salt Benzenesulfochloramide sodium Benzenesulfonamide, N-ohloro-, sodium salt Caswell No. 169 Chloramin B Chloramine B Chlordetal Chlorogen N-Chlorobenzenesulfonamide sodium N-Chloro-N-sodiobenzenesulfonamide EINECS 204-847-9 ERA Pesticide Chemical Code 076501 HSDB 3422 Khloramin B Monochloramine B Neomagnol NSC 75446 Sodium, (chloro(phenylsulfonyl)amino)- Sodium, (N-... 

Plant. Chlorsulfiiron is metabolized by plants to hydroxylated, nonphytotoxic compounds including 2-chloro-A-(((4-methoxy-6-methy 1-1,3,5-triazin-2-yl)-amino)carbo-nyl)benzenesulfonamide (Duke et al., 1991). Devine and Bom (1985) and Peterson and... 

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