Amides Aminobenzoic acid

Syntheses starting from amides of 2-aminobenzoic acid and 2-aminobenzophenone derivatives are also known.34,35... 

This fully aromatic amide, based oil the amino acid p-aminobenzoic acid, can be spontaneously synthesized from p-aminobenzoic chloride.7 9 72 To prevent this occurring at an unwanted moment, the amine group is masked by forming the hydrochloric acid salt with hydrochloric acid. 

Dialkylphosphonoacetic acid esters react with p-aminobenzoic acid to anilides. The potassium salt of the diamyl ester is said to be surface-active [126]. Phosphorus organic carbonic acid amides can also be obtained by the following reaction [127] see Eq. (76). 

In the context of synthesis and exchange reactions of biodegradable drug-binding matrices, starch trisuccinic acid was loaded via imidazolides with amines such as n-butylamine, morpholine, 4-aminobenzoic acid, or 3,4-dihydroxyphenylalanine to prepare the respective amides in high yields [160] an example is presented below. 

With N,0 mixed donor ligands several complexes have been reported with ligands such as 4,5-dichloro-2-cyano-3,6-dione-l,4-cyclohexen-l-ol,1445 isonicotinic acid,1446 p-aminobenzoic acid,1447 alanine, histidine or histamine derivatives,1448-1450 [N(0)C(CN)2]-,1451 pyridine-carboxylate derivatives, 1452 1454 [N(pph20)2] (263),1455 bis(sulfonyl)amide derivatives,1456,1457 tris(pyridyl)-... 

Amino acids " " and aminobenzoic acids " " react as nitrogen nucleophiles to effect ring opening of unsaturated 5(4//)-oxazolones. Cyclization of the intermediate acylamino amide has opened the way for the synthesis of new series of imidazolones that now incorporate a carboxylic acid moiety into the N-1 substituent. These compounds are readily further elaborated into derivatives with diverse biological activity. 

Antimicrobial sulpha drugs, e.g. sulphanilamide, are the amide of sulpha-nilic acid, and certain related substituted amides. Sulphanilamide, the first of the sulpha drugs, acts by inhibiting the bacterial enzyme that incorporates para-aminobenzoic acid into folic acid. Sulphanilamide is a bacteriostatic drug, i.e. inhibits the further growth of the bacteria. 

The ester-type local anesthetics are metabolized to p-aminobenzoic acid derivatives. These metabolites are responsible for allergic reactions in a small percentage of the patient population. Amides are not metabolized to p-aminobenzoic acid, and allergic reactions to amide local anesthetics are extremely rare. 

Biotinidase activity in plasma is quantitated by a simple colorimetric assay that uses the artificial substrate B-PABA. Biotinidase cleaves the amide bond of B-PABA forming free biotin and p-aminobenzoic acid (PABA). PABA is then converted to a purple azo dye and quantitated spectrophotometrically. No colour develops when biotinidase is inactive. Biotinidase with reduced affinity for the substrate (Km variant) can be detected by simultaneous assay of the activity with two substrate concentrations, a saturating standard concentration of 0.15 mM and a ten-times higher concentration of 1.5 mM [26]. Greater than 1.2 times higher activity with the higher substrate concentration indicates a Km defect. 

Ethane (crit. temp., upper layer, 39.8) LCST, 38.1 n-Heptane Cyclohexane Decalin Tetralin Paraffin waxes Paraffinic oils Naphthenic oils Higher alcohols (Cf. Figure Fourteen Amides Five primary Amines Six secondary Amines Three tertiary Amines m-Aminobenzoic acid (m.p. 174)... 

ETHYL ALCOHOL (continued) Thirteen fatty Acids Fourteen Amides (in 95% EtOH) m-Aminobenzoic acid (m.p. 174) jd-Ami noben zoic acid (m.p. 187) Anisic acid (m.p. 134.2) Anthranilic acid (m.p. 147) Benzamide (m.p. 130)... 

Diazonium groups are able to couple at the C-8 position of adenosine or guanosine residues, forming diazo bonds. p-Aminobenzoyl biocytin can be used in this reaction to add a biotin handle to purine bases within oligonucleotides (Chapter 8, Section 3.5). This biotinylation reagent contains a 4-aminobenzoic acid amide derivative off the... 

For the preparation of anthranilic acid the starting material is phthalimide, the cyclic imide ring of which is opened by alkaline hydrolysis in the first step of the reaction to give the sodium salt of phthalimidic acid (the half amide of phthalic acid). The intermediate undergoes the Hofmann reaction in the manner outlined on p. 783 yielding o-aminobenzoic acid (anthranilic acid). 

The ester-containing local anesthetics become metabolized to p-aminobenzoic acid derivatives, which have a potential for causing hypersensitivity reactions. Allergic reactions to amide are... 

Assignment of the weakly acidic group (pK 10.4) of amicetin to the amide linkage between cytosine and p-aminobenzoic acid was confirmed163 by the synthesis of JV-benzoyl-1 -methylcytosine (XLIa) by benzoylation of 1-methylcytosine. This cytosine derivative (XLIa), upon titration,... 

Acepifylline Fluspirilene 1340 2-Bromo-2-ethyl-3-hydroxybutyr- amide 1547 Acetylcysteine Aminobenzoic Acid... 

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