Amcinonid - Amcinonide

Compounds having the 16,17 ketal, eg, budesonide, amcinonide, fluocinonide, halcinonide, triamcinolone acetonide, and flurandrenohde, also undergo metabohsm by routes that parahel that of cortisol metabohsm. Unsymmetrical acetals such as budesonide are also metabolized by routes not available to the more metabohcahy stable symmetrical 16a,17a-isopropyhdiene-dioxysubstituted compounds (desonide, flunisohde, and triamcinolone acetonide). Isozymes within the cytochrome P450 3A subfamily are thought to catalyze the metabohsm of budesonide, resulting in formation of 16a-hydroxyprednisolone and 6P-hydroxybudesonide (19,20) (Fig. 3) in addition to the more common metabohc steps (oxidation via reduction of A, etc). 

C24H3iFOft, 76-25-5) see Triamcinolone bcnctonide Triamcinolone hexacetonide triamcinolone cyclopentanonide (C2fiH33pOf, 55646-99-6) see Amcinonide... 

Amcinonide Cyclocort cream, lotion, oint 0.1% High... 

Examples of group I, i.e. weak or low efficacy topical steroids, are hydrocortisone acetate in various concentrations, methylprednisolone 1.0% and prednisolone 0.5%. Group II, the moderately potent steroids, includes alclometasone dipropionate 0.05%, hydrocortisone butyrate 0.1%, triamcinolone acetonide 0.025% and fluocinolone ace-tonide 0.01%. Group III, the potent steroids, contains among others betamethasone valerate 0.1%, betamethasone dipropionate 0.05%, budesonide 0.025%, desoximetasone 0.05%, fluticasone propionate 0.05%, amcinonide 0.1%, fluocinonide 0.05% and mometasone furoate 0.1%. Group IV comprises the very potent agents such as clobetasol propionate 0.05% and halobetasol propionate 0.05%. 

Contraindications History of hypersensitivity to amcinonide or other corticosteroids. 

Potent, fluorinated topical corticosteroid with comparable efficacytofluocinonide, diflorasone, amcinonide, betamethasone, dipropionate, and halcinonide cost should govern use... 

A 22-year-old male with a five-year history of bronchial asthma has developed increased frequency and severity of acute asthmatic attacks. A low dose of which inhaled steroid could be added to his treatment regimen Prednisolone Amcinonide Beclomethasone Cortisone Fluocinolone... 

Amcinonide Cyclocort White petrolatum, magnesium aluminum silicate... 

---