Alveolar damage

Balkisson R, Murray D, Hoffstein V Alveolar damage due to inhalation of amitrole-containing herbicide. Chest 101 1174-1176, 1992... 

Asbestosis, alveolar damage, diffuse pleural fibrosis, lung cancer Acute upper airway injury, tracheobronchitis, chemical pneumonitis, beryllosis Upper airway injury, pneumonitis Byssinosis... 

Chronic salicylate toxicity can cause pulmonary injury, leading to respiratory distress. Lung biopsy may show diffuse alveolar damage and fibrosis (20). 

Acute interstitial pneumonia or diffuse alveolar damage in the context of other manifestations of overdose has been described (SEDA-22, 84). 

In patients with definite or probable methotrexate-induced lung injury, the predominant clinical features include shortness of breath, cough, and fever (13). Pathological examination usually shows an interstitial inflammatory cell infiltrate (sometimes granulomatous or with alveolar damage), and variable degrees of interstitial fibrosis. Unfortunately, confirmatory evidence is sometimes hard to obtain, particularly in patients with rheumatoid arthritis in whom rheumatoid interstitial lung disease can also occur. Infectious pneumonias, particularly viral or Pneumocystis jiroveci pneumonia, which resemble methotrexate pneumonitis and can occur as a result of immunosuppression, should also be carefully excluded. 

Late pulmonary complications cover a wide spectrum of disorders and include both obstructive and restrictive lung diseases. Included in these disorders are bronchiolitis obliterans with or without organizing pneumonia, diffuse alveolar damage, and lymphocytic interstitial pneumonia. 9,80 xjjgj- py consists of steroids, which are... 

FIGURE 3.33 SARS. Lung showing diffuse alveolar damage and SARS-CoV nucleic acids primarily in pneumocytes as seen by colorimetric ISH. (Immunoalkaline phosphatase with naphthol fast red substrate and hematoxylin counterstain original magnification x158.)... 

Hakkinen PJ, Haschek WM. 1982. Pulmonary toxicity of methylcyclopentadienyl manganese tricarbonyl Nonciliated bronchiolar epithelial (Clara) cell necrosis and alveolar damage in the mouse, rat, and hamster. Toxicol Appl Pharmacol 65 11-22. 

Mice exposed to 100 % O2 died after 3 or 4 d with diffuse alveolar damage and alveolar oedema (Ba-RAzzoNE et al. 1998). Extensive cell death was evi-... 

The term drug induced pneumonitis includes mainly diffuse alveolar damage, non-specific interstitial... 

Respiratory More cases of respiratory adverse reactions to leflunomide have been reported, manifesting as interstitial pneumonitis [33" ], diffuse alveolar damage with secondary organizing pneumonia [34" ], and diffuse alveolar hemorrhage [35" ]. A review counted 32 cases of leflunomide-induced pneumonitis (not including the one mentioned above) reported in the English language literature [36 ]. 

Usual interstitial pneumonia Nonspecific interstitial pneumonia Organizing pneumonia Diffuse alveolar damage Respiratory bronchiolitis Desquamative interstitial pneumonia Lymphocytic interstitial pneumonia Idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis Nonspecific interstitial pneumonia (provisional) Cryptogenic organizing pneumonia Acute interstitial pneumonia Respiratory bronchiolitis-associated interstitial lung disease Desquamative interstitial pneumonia Lymphocytic interstitial pneumonia... 

Figure 4 See color insert.) Acute interstitial pneumonitis. (A) Acute diffuse alveolar damage with alveolar walls lined by eosinophilic hyaline membranes and expanded by edema and leukocytes (original magnification, 200x H E stain). (B) Chronic diffuse alveolar damage with interstitial fibrosis and architectural remodeling (original magnification, lOOx H E stain).

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