Allergy hypersensitivity reactions

This class of ADRs includes drug allergies (hypersensitivity reactions), idiosyncratic responses, or intolerance. These types of ADRs are difficult if not impossible to predict and are therefore unavoidable until sufficient knowledge of the drug and the patients taking this drug allows the development of... 

Allergy A hypersensitivity reaction of the human body due to a particular substance. 

Chen W, Mempel M. Schober W, Behrendt H, Ring 50 J Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy 2008 63 1418-1427. 

Tamagawa-Mineoka R, Katoh N, Kishimoto S Platelets play important roles in the late phase of the immediate hypersensitivity reaction. J Allergy Clin Immunol 2009 123 581-587, 587.el-9. 

Positive basophil activation tests were reported in patients with immediate RCM hypersensitivity reactions, which may be regarded as another indirect indication for an IgE-mediated allergy [35]. 

Brockow K. Christiansen C, Karmy G, et al Management of hypersensitivity reactions to iodinated contrast media. Allergy 2004 60 150-158. 

Brockow K, Romano A, Aberer W et al Skin testing in patients with hypersensitivity reactions to iodinated contrast media - a European multicenter study. Allergy 2009 64 234-241. 

Aberer W. Bircher A, Romano A, et al Drug provocation testing in the diagnosis of drug hypersensitivity reactions general considerations. Allergy 2003 58 854-863. 

These are called delayed hypersensitivity reactions since they normally occur 6-24 hours after exposure. A cell-mediated allergy involves the interaction of food allergens with sensitised lymphocytes, which usually occurs in the gastrointestinal tract. The sensitised lymphocytes produce lymphokines and the generation of cytotoxic T lymphocytes. These latter cells destroy other intestinal cells, including the epithelial cells that are critical for absorption. 

If a patient has a mild, delayed allergy to penicillin, first-generation cephalosporins are effective alternatives but should be avoided in patients with an immediate-type hypersensitivity reaction. 

The most common side effects include somnolence, dizziness, anorexia, headache, nausea, word-finding difficulties, oligohidrosis, modest weight loss, and irritability. Symptomatic kidney stones may occur in 2.6% of patients. Hypersensitivity reactions may occur in 0.02% of patients, and it should be used with caution if at all in patients with a history of allergy to sulfonamides. Monitoring of renal function may be advisable in some patients. 

Immunoenhancement, which, as adverse effect, may lead to immune-mediated diseases such as hypersensitivity reactions and autoimmune diseases. Hypersensitivity reactions are the result of normally beneficial immune responses acting inappropriately, causing inflammatory reactions and tissue damage. The two most frequent manifestation of chemical-induced allergy are contact hypersensitivity and respiratory sensitization, both of which can have a serious impact on quality of life and represent a common occupational health problem. Hypersensitivity reactions are often considered to be increased at such a rate to become a major health problem in relation to environmental chemical exposure. 

Hypersensitivity (allergy) is defined as humoral or cellular responses to an otherwise innocuous antigen, which can lead to tissue damage. Hypersensitivity reactions... 

Dearman, R J. et al., Differential ability of occupational chemical contact and respiratory allergens to cause immediate and delayed dermal hypersensitivity reactions in mice. Int. Arch. Allergy Immunol., 97, 315, 1992. 

Weiss, M.E. and Adkinson, N.F., Immediate hypersensitivity reactions to penicillin and related antibiotics, Clin. Allergy, 18, 515, 1988. 

Adkinson, Jr., N.F. et al., Task force report future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions, J. Allergy Clin. Immunol., 109, S461, 2002. 

Non-allergic hypersensitivity reaction corresponds with the traditional term food intolerance . It affects about 20% of patients, inducing symptoms similar to those observed during an allergy bout, however, it is triggered by non-immunological mechanisms. 

Hypersensitivity reactions Heparin is derived from animal tissue use with caution in patients with a history of allergy. Before a therapeutic dose is given, a trial dose may be advisable. Have epinephrine 1 1000 immediately available. 

Hypersensitivity reactions Hypersensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma cross-sensitivity with sulfonamides may also occur. Refer to Management of Acute Hypersensitivity Reactions. 

Hypersensitivity reactions Hypersensitivity reactions may occur, and any of the usual manifestations of drug allergy may develop. 

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