Allergic airway inflammation chemokine roles

Conroy, D. M., Humbles, A. A., Rankin, S. M., Palframan, R. T., Collins, P. D., Griffiths-Johnson, D. A., Jose, P. J., and Williams, T. J. (1997) The role of the eosinophil-selective chemokines, eotaxin, in allergic and non-allergic airways inflammation, in New Perspectives in Eosinophils. Role in Inflammation Associated with Allergy, Asthma and Parasitic Disease (Cordeiro, R., Moqbel, R., and Weller, P. F., eds.), Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil, pp. 183-191. 

Other CC chemokines are likely also important in the development of eosinophilic airway inflammation. MCP-3 (MARC/FIC) was originally isolated from mast cells, which would immediately center a role for this eosinophil chemoattractant on early allergic responses. Depletion of MCP-3 in allergic airway models has demonstrated a significant role for this molecule on eosinophil recruitment to the airways (39). In addition, studies in our own laboratory examining the role of other CC chemokines, specifically MIP-la, have demonstrated that it is not only important in mononuclear recruitment... 

Bronchial biopsies in stable atopic asthmatics have observed these components (19,64). Several Th2-type cytokines, (IL-4, IL-5, IL-13, but not JFNy) and C-C chemokines are produced by multiple cells types, which regulate IgE synthesis and lead to the generation of eosinophilic airway inflammation (Fig. 9) (321). Allergic tissue damage results from the release of basic proteins, leukotrienes, and PAF secreted by activated eosinophils. It is clear that the mast cell plays an important role in the immediate response and that T cells play a key role in orchestrating the nature and severity of the inflammation by the secretion of cytokines. As stated earlier, the eosinophil is regarded as the primary effector cell due to the capacity to secrete major basic protein and eosinophil cationic protein, which have profound cytotoxic effects on the airway epithelium (316). 

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