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Alkyl reduction

The Reissert method15—conversion of an isoquinoline to a 2-benzoyl-1,2-dihydroisoquinaldonitrile (Reissert compound), alkylation, and hydrolysis—has enjoyed wide success in the synthesis of benzyliso-quinoline and related alkaloids.16,17 In particular, aporphines are prepared conveniently by converting isoquinolines to I-(o-nitrobcnzyl)-isoquinolines via a Reissert sequence, followed by A7-alkylation, reduction, and Pschorr cyclization.17... [Pg.23]

This procedure illustrates a general method for preparing aromatic hydrocarbons by the tandem alkylation-reduction of aromatic ketones and aldehydes.2 Additional examples are given in Table I. [Pg.9]

White-rot fungus has been used as a biocatalyst for reduction and alkylation. The reaction of aromatic -keto nitriles with the white-rot fungus Curvularia lunata CECT 2130 in the presence of alcohols afforded alkylation-reduction reaction [291]. Alcohols such as ethanol, propanol, butanol, and isobutanol could be used (Figure 8.39d). [Pg.223]

Keywords Cyanohydrin acetonide alkylations. Reductive decyanations, Oxocarbenium ions. Reductive lithiation... [Pg.51]

During the course of the development of our group s alkylation/reductive decyanation strategy, a very reliable method for distinguishing between syn-and anfz-l,3-diols was discovered [17,18]. The acetonide methyl groups reliably display diagnostic C-NMR chemical shifts, allowing for stereochemistry to be determined simply by inspection (Fig. 1). Evans later extended the C-NMR chemical correlation to polypropionate chains [19,20]. [Pg.57]

A recent interesting example of the chiral amplification of a small initial e.e. has been reported by Soai et al. [113,114] involving the induction of a chiral center in an achiral aldehyde using diisopropylzinc as an alkylating reductant and a very small... [Pg.189]

Pyrrolo[l,2-(7][l,2,5]benzotriazepin-ll-one 329 is the product of a sequence starting from N-(2-nitrophenyl)-lH-pyrrol-l-amine 327. The pathway included alkylation, reduction of the nitro group, formation of the isocyanate from intermediate 328 and intramolecular thermal cyclization (Scheme 69 (2000JHCl539)). [Pg.50]

Sultines can be versatile synthetic intermediates for example, they undergo ring-opening reactions, alkylation, reductive desulfurization , and oxidation at sulfur to give sultones. [Pg.688]

Acylations, Alkylations, Reductive Alkylations (Aminations, Alkaminations)... [Pg.451]

Selective reductions.1 Zinc bo and a,P-enals at -15° without effc Reduction of azomethines.s Z ary amines or the amine-BH3 compfc alkylation-reduction of nitriles to j... [Pg.388]

Reduction of azomethines,3 Zn(BH4)2 in ether reduces Schiff bases to secondary amines or the amine BH3 complex in high yield. This procedure can be applied to alkylation-reduction of nitriles to yield 1-phenylalkylamines. [Pg.389]

Fig. 2. Fluorous biphasic catalysis part II asymmetric alkylation, reduction, oxidation, and cross-coupling reactions with fluorous tagged catalysts. Fig. 2. Fluorous biphasic catalysis part II asymmetric alkylation, reduction, oxidation, and cross-coupling reactions with fluorous tagged catalysts.
The essence of the cascade synthesis is depicted in Scheme 2.1. Two procedures, alkylation and reduction, comprised the [a — b — a — b — ] sequence. Thus, treatment of a diamine with acrylonitrile afforded tetranitrile 3. Cobalt-mediated nitrile reduction gave tetraamine 4. Further amine alkylation provided the second generation octanitrile 5. The nonskid-chain-like [2] synthesis is shown in Scheme 2.2. Construction of polycyclic 6 was accomplished by repetitive alkylation, reduction, acylation, and reduction (a — b c— d—>a- b— ...) sequences. Again, repetitive and multiple reaction sequences were employed for the generation of new molecular assemblies. Most notable about these syntheses is that for the first time, generational molecules were prepared and characterized at each stage of the construction process. [Pg.19]


See other pages where Alkyl reduction is mentioned: [Pg.761]    [Pg.47]    [Pg.68]    [Pg.1658]    [Pg.51]    [Pg.53]    [Pg.106]    [Pg.110]    [Pg.440]    [Pg.174]    [Pg.421]    [Pg.262]    [Pg.93]    [Pg.134]    [Pg.135]    [Pg.297]    [Pg.657]    [Pg.164]    [Pg.1279]    [Pg.761]    [Pg.206]    [Pg.206]    [Pg.96]    [Pg.163]   
See also in sourсe #XX -- [ Pg.98 ]

See also in sourсe #XX -- [ Pg.38 ]




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A-Alkylation reductive

A-Carbolinium salts, alkyl reduction

Acylation-reduction, alkylation

Acylation-reduction, alkylation benzene

Alcohols reductive alkylation

Alcohols, oxidizing reagents reductive alkylation

Aldehydes, reductive alkylation

Aldehydes, reductive alkylation alkenes, reagents

Aldehydes, reductive alkylation reagents

Aldehydes, reductive alkylation tautomerism

Aldehydes, reductive alkylation vinylation

Aldehydes, reductive alkylation with alcohols

Alkanes via alkyl halide reduction

Alkenes reductive coupling with alkyl halides

Alkyl Halide Reduction and Stereochemical Effects

Alkyl aldimines, reduction

Alkyl aryl ethers, reduction

Alkyl aryl sulfoxides reduction

Alkyl asymmetric reductions

Alkyl azide, amines from reduction

Alkyl azides reduction

Alkyl benzenes reduction

Alkyl benzyl carbamates, reduction

Alkyl benzyl carbonates, reduction

Alkyl chlorides, reduction

Alkyl dihalides, reductive 1,3-elimination

Alkyl dihalides, reductive 1,3-elimination reactions

Alkyl fluorides reduction with lithium aluminum hydride

Alkyl fluorides, reduction

Alkyl hahdes reduction

Alkyl halide, reduction with organotin

Alkyl halide, reduction with organotin hydride

Alkyl halides aromatic anion radical reduction

Alkyl halides electrochemical reduction

Alkyl halides electrochemical reductive cleavage

Alkyl halides homogeneous reductive cleavage

Alkyl halides reduction potentials

Alkyl halides reduction potentials, 269, Table

Alkyl halides reductive elimination from

Alkyl iodides reduction

Alkyl methanesulfonates, reduction

Alkyl perfluoro carboxylates reduction

Alkyl peroxides reduction

Alkyl pyridyl ketones, reduction

Alkyl radicals, reduction potentials

Alkyl reductive elimination

Alkyl sulfonates reduction

Alkyl sulphides, reduction

Alkyl thiocyanates, reduction

Alkyl-1,6-naphthyridines reduction

Alkylation Birch reductive

Alkylation Reductive amination

Alkylation reactions reductive

Alkylation with formaldehyde, reductive

Alkylation, enolate ions reduction

Alkylation-reduction reaction

Alkylations, reductive

Aluminum chloride alkyl halide reduction

Amines Eschweiler-Clark reductive alkylation

Amines by reductive alkylation

Amines from by reductive alkylation

Amines reductive alkylation

Amino groups reversible reductive alkylation

Ammonia reductive alkylation

Ammonium formate reductive alkylation of amines

Ammonium salts, alkyl reduction

Ammonium salts, alkyl tetraalkyl, reduction

And reductive alkylation

Anthracene reductive alkylation

Aryl alkyl ketone, reduction

Aryl alkyl ketones reductive amination

Aryl alkylation, reductive

Asymmetric Birch reductive alkylation

Azides reductive alkylation

Azides, from alkyl halides reduction

Azines, alkylation reduction

Benzoic acid, 4- intramolecular reductive alkylation

Biphenyl, reductive alkylation

Birch reduction-alkylation

Birch reductive alkylation oxidation with

By reduction of alkyl halides

C-Alkylation reductive

Carbonyl compounds reductive alkylation

Catalytic hydrogenation reductive alkylation

Catalytic reductive alkylation

Chloroformates, alkyl, reduction

Clark-Eschweiler reductive alkylation of amines

Clark—Eschweiler reductive alkylation

Conjugate reduction-allylic alkylation reactions

Dimethyl sulfate, alkylation reduction

Dissolving metal conjugate reduction a-alkylated ketones

Disulfide bonds reduction/alkylation

Dithioacetals, alkylation reduction

Elimination Reactions by Sml2 Reduction of Alkyl Halides

Enantioselective reductive alkylation

Enol Friedel-Crafts alkylation, reductive

Enones reductive alkylation

Eschweiler reductive alkylation of amines

Eschweiler-Clarke Methylation (Reductive Alkylation)

Eschweiler-Clarke reductive alkylation

Eschweiler-Clarke reductive alkylation amines

Eschweiler-Clarke reductive alkylation of amines

Ethylamine, cyclohexylsynthesis via reductive alkylation of azidocyclohexane

Ethylene alkylation, reductive

From reduction of alkyl halides

Grignard reagents from alkyl halide reduction

Halides, alkyl reduction

Heterogeneous catalysis reductive alkylation

Hydrocarbons reductive alkylation treatment

Hydrogenation reductive alkylation

Hydrogenation, of a double bond over Raney nickel for reductive alkylation

Hydrogenolysis during reductive alkylations

Hydroxy amines reductive alkylation

INDEX reductive alkylation

Imines, alkylation reduction

In reductive alkylation

Intermolecular reactions reductive alkylation

Isoquinoline reductive alkylation

Ketones alkyl, reduction

Ketones alkylation, reductive

Lithium alkyl halide reduction

Lithium aluminum hydride alkyl halide reduction

Lupeol reduction-alkylation

N-Alkylation reductive

N-Methylarylamines, preparation by reductive alkylation

N-Methylarylamines, preparation reductive alkylation

Naphthalene reductive alkylation

Nitro compounds reductive alkylation

Nitrogen reductive alkylation

Nitroso compounds reductive alkylation

Organocopper-mediation reduction-alkylation

Organolithium compounds from alkyl halide reduction

Oxidative Addition and Reductive Elimination of Alkyl Halides

Piperazinediones by Acid Cyclative Cleavage Method A, including Reductive Alkylation

Platinum catalysts, sulfided reductive alkylation

Potassium alkyl fluoride reduction

Preparation of Amines by Reductive Alkylation

Progesterone reduction-alkylation

Protein reductive alkylation

Protein reductive alkylation using transfer

Proteins reduction-alkylation

Pyrroles reductive alkylation

Quinones, alkylation reduction

REDUCTION OF ALKYL HALIDES AND

REDUCTION OF ALKYL HALIDES AND TOSYLATES WITH SODIUM CYANOBOROHYDRIDE

Radical reactions reductive alkylation

Radical stereoselectivity reductive alkylation

Reaction acylation-reduction, alkylation

Reductants alkyl borane

Reduction alkyl bromides

Reduction alkylation

Reduction alkylation

Reduction alkylation, Cope rearrangement

Reduction and alkylation

Reduction aryl alkyl

Reduction dienolates, alkylation

Reduction of Alkyl, Alkenyl, and Aryl Halides

Reduction of alkyl azides

Reduction of alkyl bromides

Reduction of alkyl halides

Reduction prochiral aryl alkyl

Reduction reaction alkyl carbonate solutions

Reduction reaction kinetics alkyl halides

Reduction reactions Eschweiler-Clark reductive alkylation

Reduction reactions alkyl halides

Reduction reductive alkylation

Reduction reductive alkylation

Reductive Alkylation of Ammonia with Carbonyl Compounds

Reductive Alkylation of Primary Amines with Carbonyl Compounds

Reductive N-Alkylation of Primary Amides with Carbonyl Compounds

Reductive Stabilization with Aluminum Alkyls

Reductive alkylation

Reductive alkylation

Reductive alkylation Birch reduction

Reductive alkylation Lithium-Ammonia

Reductive alkylation Reformatsky reaction

Reductive alkylation affected carbons

Reductive alkylation amine precursors

Reductive alkylation application

Reductive alkylation dibenzothiophene

Reductive alkylation mechanism

Reductive alkylation of alcohols

Reductive alkylation of aldehydes and ketones

Reductive alkylation of amines

Reductive alkylation of ammonia

Reductive alkylation of methylamine

Reductive alkylation of methylamine by 2,3-dimethoxybenzaldehyde

Reductive alkylation regiochemistry

Reductive alkylation secondary amine formation

Reductive alkylation selectivity

Reductive alkylation steric factors

Reductive alkylation sulfur functionality

Reductive alkylation tertiary amine formation

Reductive alkylation treatment

Reductive alkylation with other metals

Reductive alkylation, heterogeneous hydrogenation

Reductive alkylation, indirect

Reductive alkylation, of cyanoacetic

Reductive alkylation, of cyanoacetic ester with butyraldehyde

Reductive alkylations Birch reduction

Reductive alkylations benzoic acids

Reductive alkylations metal-ammonia reduction

Reductive aminations alkylations

Reductive dehalogenation alkyl halides

Reductive elimination of alkyl halides

Reductive lithiation of alkyl phenyl sulfide

Reductive nitroarene alkylation

Secondary amines, from reductive alkylation

Secondary amines, from reductive alkylation amination)

Sodium alkyl halide reduction

Stereoselective intramolecular reductive alkylation

Subject reductive alkylation

Sulfones, alkylation reduction

Sulfoxides, alkyl reduction

Tertiary amines, from reductive alkylation

Tertiary amines, from reductive alkylation amination)

Tetrahydroquinoline, reductive alkylation

The Alkylation of Benzene by Acylation-Reduction

Three-component reductive alkylation

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