Reissert compound

Qu tern iy S Its. The ring nitrogen of quinoline reacts with a wide variety of alkylating and acylating agents to produce useful intermediates like A/-benzoylquinolinium chloride [4903-36-0] (8). The quinoline 1,2-adducts, eg, A/-benzyl-2-cyano-l,2-dihydroquinoline [13721 -17-0] (9), or Reissert compounds (28), formed with potassium cyanide can produce 2-carboxyquinoline [93-10-7] (10) or 2-cyanoquinoline [11436-43-7] (11). 

Excellent yields of the former product are also obtained with quinoline N-oxide. Improved yields of Reissert compounds are found under phase-transfer conditions (29). The regiochemistry of the method changes dramatically with /V-alkyl quin olinium salts, eg, /V-methy1quino1inium iodide [3947-76-0] (12), which form 4-cyanoquinoline [23395-72-4] (13) (30), through the intermediary in this example of A[-methyl-4-cyano-l,4-dihydroquinoline... 

Isoquinoline also forms Reissert compounds when treated with benzoyl chloride and alkyl cyanide (28), especially under phase-transfer conditions (29). The W-phenylsulfonyl Reissert has been converted to 1-cyanoisoquinoline with sodium borohydride under mild conditions (154). When the AJ-benzoyl-l-alkyl derivative is used, reductive fission occurs and the 1-alkyLisoquinoline is obtained. 

Methylpyridazine gives the pyridazine Reissert compound (105) with trimethylsilyl cyanide and freshly distilled benzoyl chloride. On the other hand, when pyridazine or 3-methylpyridazine reacts with undistilled benzoyl chloride the bicyclic compounds (106) are formed and these react with dimethyl acetylenedicarboxylate in anhydrous DMF to give pyrrolopyridazine derivatives (107 Scheme 30) (81JHC443). 

The Reissert compound obtained from phthalazine and potassium cyanide in the presence of benzoyl chloride can be converted with methyl iodide and sodium hydride in DMF into... 

Formyl-3-methylisothiazole is prepared by hydrolysis of the appropriate Reissert compound and, as the thiosemicarbazone, in poor yield by the McFadyen-Stevens reaction. 4-Formylisothiazole has been obtained by oxidation of 4-methylisothiazole although no details of the preparation have been reported. 

Heterocyclic structures analogous to the intermediate complex result from azinium derivatives and amines, hydroxide or alkoxides, or Grignard reagents from quinazoline and orgahometallics, cyanide, bisulfite, etc. from various heterocycles with amide ion, metal hydrides,or lithium alkyls from A-acylazinium compounds and cyanide ion (Reissert compounds) many other examples are known. Factors favorable to nucleophilic addition rather than substitution reactions have been discussed by Albert, who has studied examples of easy covalent hydration of heterocycles. 

The Reissert method15—conversion of an isoquinoline to a 2-benzoyl-1,2-dihydroisoquinaldonitrile (Reissert compound), alkylation, and hydrolysis—has enjoyed wide success in the synthesis of benzyliso-quinoline and related alkaloids.16,17 In particular, aporphines are prepared conveniently by converting isoquinolines to I-(o-nitrobcnzyl)-isoquinolines via a Reissert sequence, followed by A7-alkylation, reduction, and Pschorr cyclization.17... 

This reaction is illustrative of a general procedure for the alkylation of active methylene functions in the presence of concentrated aqueous alkali catalyzed by tetraalkylammonium salts. This catalytic method has been used to alkylate arylacetonitriles with monohaloalkanes,2 dihaloalkanes,3 a-chloroethers,4 chloronitriles,.5 haloacetic acid esters,6 and halonitro aromatic compounds.7 It has also been used to alkylate ketones,8 lf/ indene,9 9i/-fluorene,ll) and the Reissert compound.11 The reaction is inhibited by alcohols and by iodide ion.2... 

Reissert compounds (116) are prepared from the acyl halide by treatment with quinoline and cyanide ion. Treatment of 116 with sulfuric acid gives the... 

Several syntheses of secoquettamines have been performed. Seco compounds 234 and 235 were semisynthesized from quettamine (236) by Hofmann and Emde degradations, respectively (179). Chattopadhyay and Shamma (184) conducted a total synthesis of these bases with the intermediacy of quettamine (236) (Scheme 36). In this approach Reissert compound 237 served as substrate. On reaction with 4-benzyloxybenzaldehyde 237 supplied the addition product 238, which after N-methylation and sodium borohydride reduction afforded amino carbinol 239. Compound 239 was cyclized to... 

Apart from isolated reports summarized in Scheme 47, the chemistry of the fully conjugated ring systems has not been especially developed since CHEC-II(1996). In 1999, Monnier et al. reported the 1,3-dipolar cycloaddition of Reissert compound 160 with acrylates. Addition of triethylamine traps hydrofluoroboric acid and increases the proportion of milnchnone imine 160B the reaction therefore predominantly yields 1,3-adduct 161 which rearranges to 162 (Scheme 47) <1996BSB777, 1999EJ0297>. 

Reinforcing materials, 20 455t Reissert compounds, 22 185, 186, 201 Reissert-Henze reaction, 22 99 Relationships, as an aspect of the technical service function, 24 348 Relative abundance, 25 648, 649-650 Relative atomic ratios, determination of, 24 93-94... 

Reissert compounds (>70%), derived from benzimidazole, phthalazine, quinoline and isoquinoline, have been prepared by a simple catalysed one-pot N-acylation of the appropriate heterocycle, followed by reaction with cyanide ion [e.g. 101-103],... 

Sonication [130, 131] aids the standard phase-transfer catalysed [e.g. 132, 133] C-alkylation of Reissert compounds. As much as twofold increases in yield are observed with shortened reaction times. No alkylation is observed when sonication is used alone. 

Method A (normal conditions) The Reissert compound (8.6 mmol), alkylating agent (9 mmol) and quaternary ammonium salt (1 mmol) in PhH (20 ml) is stirred with aqueous NaOH (50%, 5 ml) for 13 h at room temperature. The mixture is adjusted to pH 6 with aqueous H,S04 (5%) and the organic phase is separated, dried (MgS04), and evaporated to yield the alkylated Reissert compound. 

Method B (with sonication) Sonication of the Reissert compound (4.6 mmol), haloalkane (6.6 mmol), and TEBA-C1 (34 mg, 0.15 mmol) in CH,C1, (2.5 ml) and aqueous NaOH (50%, 1.8 ml) is conducted for 20 min. Work-up at this stage, as described in 6.2.30.A, yields the alkylated Reissert compound. Addition of EtOH (6 ml) and sonication for a further 30 min with subsequent work-up by addition of the mixture to 11,0 (20 ml) and extraction with CH,C1, (3 x 10 ml) produces the C-alkylated heteroarene, which is isolated as the hydrochloride salt (70-90%) by saturation of the dried organic extracts with HC1 gas. 

The Reissert compound (5.7 mmol), an aryl aldehyde and TEBA-C1 (14 mg, 0.06 mmol) in CH,C1, (3 ml) are sonicated with aqueous NaOH (50%, 2.5 ml) for 5 min. EtOH (8 ml) and CH,C1, (15 ml) are added and sonication is continued for a further 85 min and the mixture is then poured into H,0 (20 ml). The aqueous phase is separated and extracted with CH2C1, (3x10 ml). The combined organic solutions are dried (MgS04), concentrated to 20 ml, and saturated with HCI gas to yield the hydroxymethylheteroarene hydrochloride (80-99% ). 

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