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Alcohols functionalization

Reaction with base brings the alcohol function of the halohydrin into equilibrium with Its corresponding alkoxide... [Pg.677]

Base promoted cyclization of vicinal halohydrms (Section 16 10) This reaction is an intramolecu lar version of the Williamson ether synthesis The alcohol function of a vicinal halohydrin is con verted to its conjugate base which then displa ces halide from the adjacent carbon to give an epoxide... [Pg.693]

Like aldehydes ketone functions take precedence over alcohol functions double bonds halogens and alkyl groups m determining the parent name and direction of numbering Aldehydes outrank ketones however and a compound that contains both an aldehyde and a ketone carbonyl group is named as an aldehyde In such cases the carbonyl oxy gen of the ketone is considered an 0x0 substituent on the mam chain... [Pg.705]

Compounds that contain both carbonyl and alcohol functional groups are often more stable as cyclic hemiacetals or cyclic acetals than as open chain compounds Examples of several of these are shown Deduce the structure of the open chain form of each... [Pg.748]

Aldoses incorporate two functional groups C=0 and OH which are capable of react mg with each other We saw m Section 17 8 that nucleophilic addition of an alcohol function to a carbonyl group gives a hemiacetal When the hydroxyl and carbonyl groups are part of the same molecule a cyclic hemiacetal results as illustrated m Figure 25 3 Cyclic hemiacetal formation is most common when the ring that results is five or SIX membered Five membered cyclic hemiacetals of carbohydrates are called furanose forms SIX membered ones are called pyranose forms The nng carbon that is derived... [Pg.1032]

The carbonyl group of carbohydrates can be reduced to an alcohol function Typi cal procedures include catalytic hydrogenation and sodium borohydnde reduction Lithium aluminum hydride is not suitable because it is not compatible with the solvents (water alcohols) that are required to dissolve carbohydrates The products of carbohydrate reduc tion are called alditols Because these alditols lack a carbonyl group they are of course incapable of forming cyclic hemiacetals and exist exclusively m noncyclic forms... [Pg.1052]

The reaction of aldoses with nitric acid leads to the formation of aldaric acids by oxidation of both the aldehyde and the terminal primary alcohol function to carboxylic acid groups Aldaric acids are also known as saccharic acids and are named by substi tutmg aric acid for the ose ending of the corresponding carbohydrate... [Pg.1054]

Step 2 The ketone carbonyl of the acetoacetyl group is reduced to an alcohol function This reduction requires NADPH as a coenzyme (NADPH is the phosphate ester of NADH and reacts similarly to it)... [Pg.1076]

In the next step the —OOH group of PGG2 is reduced to an alcohol function Again prostaglandin endoperoxide synthase is the enzyme responsible The product of this step IS called PGH2... [Pg.1081]

Cholesterol was isolated m the eighteenth century but its structure is so complex that Its correct constitution was not determined until 1932 and its stereochemistry not verified until 1955 Steroids are characterized by the tetracyclic ring system shown m Figure 26 9a As shown m Figure 26 9b cholesterol contains this tetracyclic skeleton modified to include an alcohol function at C 3 a double bond at C 5 methyl groups at C 10 and C 13 and a C Hn side chain at C 17 Isoprene units may be discerned m var lous portions of the cholesterol molecule but the overall correspondence with the iso prene rule is far from perfect Indeed cholesterol has only 27 carbon atoms three too few for It to be classed as a tnterpene... [Pg.1093]

Thiamine forms the expected derivatives of the thia zole alcohol function, such as carboxyUc and phosphate esters. Eew reactions at the pyrimidine 4-amino function have been reported. Most of the usual conditions used for formation of amides, for example, lead to destmction of the thiazolium ring. [Pg.87]

Although lead tetraacetate can attack many polar and nonpolar functions in the steroid molecule, its greatest reactivity is towards vicinal diols. These diols are generally cleaved so rapidly under stoichiometric conditions that other alcohol functions in the molecule need not be protected. Thus lead tetraacetate in acetic acid at room temperature splits the 17a,20-diol group in (9) to yield the 17-ketone (10), the allylic A -3jS-alcohol remaining intact during this oxidation. Since lead tetraacetate is solublein many anhydrous... [Pg.242]

The user should be aware though of the presence of other functions in the matrix of the packing the initiator used, azobisisobutyronitrile, leaves a small amount of CN functions in the packings. Also, small amounts of alcohol functions cannot be excluded, especially as the packing ages. For most applications, these small amounts of residual side functions are of little concern. [Pg.327]

Silyl ethers are among the most frequently used protective groups for the alcohol function. This stems largely from the fact that their reactivity (both formation and cleavage) can be modulated by a suitable choice of substituents on the silicon atom. Both steric and electronic effects are the basic controlling elements that regulate the ease of cleavage in multiply functionalized substrates. In plan-... [Pg.113]

The terms primary- secondary, tertiary, and quaternary are routinely used in organic chemistry, and their meanings need to become second nature. For example, it we were to say, "Citric acid is a tertiary alcohol," we would mean that it has an alcohol functional group (-OH) bonded to a carbon atom that is itself bonded to three other carbons. (These other carbons may in turn connect to other functional groups). [Pg.85]

In the synthesis of the squalenoid glabrescol (72 originally attributed structure), containing five adjacent (all cis) THF rings, the necessary precursor of the polyepoxide cascade, the pentaepoxide 71, was achieved by epoxidation of each of the trisubstituted double bonds of the known (R)-2,3-dihydroxy-2,3-dihydrosqualene (70) by the Shi epoxidation approach (Scheme 8.18) [34]. Treatment of 71 with CSA at 0 °C and subsequent purification by column chromatography provided the pure polycyclic ether 72 by a cascade process reasonably initiated by the free secondary alcohol functionality [35a]. [Pg.283]

A mechanism for its formation was also proposed. Essentially, this involved protonation of 2-methylfuran followed by dimerization and trimerization to a 2,4-difuryl tetrahydrofuran derivative which suffered an acid catalysed cleavage of the saturated ring to produce a carbenium ion possessing an alcoholic function at the other end of... [Pg.60]

Diol-functionalized telechelic polymers have been desired for the synthesis of polyurethanes however, utilizing alcohol-functionalized a-olefins degrades both 14 and 23. Consequently, in order for alcohols to be useful in metathesis depolymerization, the functionality must be protected and the oxygen atom must not be /3 to the olefin or only cyclic species will be formed. Protection is accomplished using a/-butyldimcthylsiloxy group, and once protected, successful depolymerization to telechelics occurs readily. [Pg.457]

Oxirane57). If the conditions are chosen such as to avoid propagation (low temperature, Li+ or Na+ are better counterions than K+ in this respect) one single oxirane unit is added, yielding after protonation a polymer fitted at chain end with an alcohol function. [Pg.156]

Alcohol functions have also been introduced via hydrosilylation reactions, for example, the reaction of T8[OSiMe2H]8 with allyl alcohol and allyloxy ethanol (Table 19). In the first case, it has been postulated that the compound T8[OSiMe2 (CH2)30H]8 is not very stable due to back-biting of the -OH groups on the silicon corners (Figure 31). Nevertheless, it reacts with polymers such as polyvinyl pyrrolidone to give polymer hybrids (Table 19, entries 4 and 5). [Pg.55]


See other pages where Alcohols functionalization is mentioned: [Pg.361]    [Pg.479]    [Pg.159]    [Pg.200]    [Pg.123]    [Pg.196]    [Pg.128]    [Pg.617]    [Pg.201]    [Pg.84]    [Pg.12]    [Pg.190]    [Pg.92]    [Pg.189]    [Pg.274]    [Pg.277]    [Pg.394]    [Pg.446]    [Pg.313]    [Pg.285]    [Pg.22]   
See also in sourсe #XX -- [ Pg.314 ]




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Alcohol Mixed function oxidase

Alcohol and function

Alcohol functional group

Alcohol groups functionalization with

Alcohols dehydrogenative functionalization

Alcohols functional class nomenclature

Alcohols functional group interconversions

Alcohols functional groups among

Alcohols functionalized ketones from

Alcohols, functionalized dienes

Alcohols, tert., 2-functionalized

Alcohols, tert., 2-functionalized ketones

Aliphatic alcohols, functional groups

Aliphatic alcohols, functional groups among

Carboxylic acids, functional derivatives reaction with alcohols

Equatorial secondary alcohol functionality

Ferrocenyl alcohols, functionalized

Functional alcohol

Functional alcohol

Functional class nomenclature of alcohols

Functional group of alcohols

Functional groups in alcohols

Functional groups, organic alcohols

Functionalized alcohols

Functionalized alcohols

Functionalized alcohols 2- ethanol

Functionalized alcohols INDEX

Functionalized primary alcohols

Homoallylic alcohols synthetic function

Hydroxy Functional Group Alcohols Properties, Preparation, and Strategy of Synthesis

Introduction to Functional Groups and Alcohols

Liver alcohol dehydrogenase, function

Of primary alcohol function

Olefins and Functional Derivatives in the Presence of Alcohols

Oxidation States of Alcohols and Related Functional Groups

Oxidation of Secondary Alcohol Functions

Oxidation of primary alcohol functions

Reproductive functioning, alcohol

Safety-sensitive function.Alcohol drug testing

Secondary allylic alcohol functionality

Sexual function alcohol effects

Substituted hydrocarbons: alcohols ethers, 794 functional groups

Trifluoroacetic anhydride functionalizing alcohol groups

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