Biochemical tests, alcoholism

The mean disappearance rate of BSP is slightly reduced in alcoholics without other evidence of liver dysfunction (G14) and is significantly reduced when there is other evidence of liver dysfunction. It has been found (Cll, C17) that BSP values in alcoholics correlate better with the degree of histological change in the liver than any of the other biochemical tests studied. Alcohol has an acute depressant effect on BSP excretion in experimental animals (see Section 7.10). 

Currently, there is no biochemical test to confirm alcohol abuse. However, the combination of an increased serum yGT and urate with a macrocytosis is strongly suggestive of alcohol abuse. 

De Vincenzi M, Luchetti R, Giovannini C, Pogna NE, Saponaro C, Galterio G, et al. In vitro toxicity testing of alcohol-soluble proteins from diploid wheat Triticum mono-coccum in celiac disease. J Biochem Toxicol 1996 11 313-318. 

The tools for nutritional assessment include medical history and screening aides, physical examination and anthropometric measurements, biochemical assessment, and tests of immune function. A general health assessment and medical history are required to rule out causes of secondary malnutrition such as poor oral health, chronic illness, disease, and medication. Malnutrition is influenced by lifestyle, which includes alcohol usage in adults, food preference, eating habits, social interactions, and economic status. Various screening tools, such as the DETERMINE checklist (White et al., 1991), are available to assess the risk of malnutrition. 

An increase in the retention of sodium occurs in the early stages of severe liver disease, particularly in liver cirrhosis, without any disruption of the water balance. This early tendency towards sodium retention can be detected using the NaCl-tolerance test. The retention of sodium reduces the sodium excretion rate in the urine to < 10 mval/day (normal rate 120 to 220 mval/day). Diuresis is not primarily restricted patients with ascites and oedema react to an excessive intake of water with an adequate excretion of diluted urine, albeit in the virtual absence of sodium excretion. The limited sodium excretion derives from increased, mainly proximal tubular reabsorption of sodium and not from diminished glomerular filtration. Overall maintenance of the liver architecture is usually accompanied by undisturbed sodium excretion, despite existing portal hypertension (such as in primary biliary cirrhosis). Marked sodium retention is, however, usually found in alcoholic-toxic cirrhosis. For this reason, such patients are not only the ones most frequently affected by ascites and oedema, but as a rule they display the most serious forms. This is probably also due to additional biochemical and hormonal factors which are present to a greater degree in patients with alcohol-related liver disease. 

Say Cheese Redox in Photography Having a Blast Redox in a Blast Furnace Redox in Bleaching Processes Corrosion of Metals Silver Tarnish A Redox Reaction Chemiluminescence It s Cool Biochemical Redox Processes MiniLab 16.2 Testing for Alcohol by Redox... 

These data show biochemical evidence that heavy alcohol consumption can produce significant deterioration in the integrity of the hepatocyte since in the majority of heavy drinkers a rise in plasma GST occurred after the alcohol load. The study also suggested that there was considerable interindividual variation in the plasma GST response to alcohol even in moderate drinkers, suggesting that the test might be a useful predictor of susceptibility to alcohol-induced liver damage. Further detailed studies are required to clarify if this is the case and a comparison of the responses in males and females would be of interest. 

Classification Phospholipids Formula CH20RiCH0R2CH20P(0)(0H)0R3 Properties YIsh. amorphous char, odor and taste insol. in water, acetone sol. in chloroform, ether si. sol. in alcohol dens. 1.00 Uses Medicine biochemical research diagnostic use clinical reagent (liver function test) skin conditioner in cosmetics promotes blood clotting in after-shave prods. Manuf./Distrib. Fluka http //www.sigma-aldrich.com] Sigma... 

Posch, K C and Napoli, J L. (1992) Multiple retinoid dehydrogenases in testes cytosol from alcohol dehydrogenase negative or positive deermice Biochem Pharmacol 43,2296-2298... 

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