Administration Indicators

67 = the number of prescriptions/medication orders for high-alert medications that are double-checked and documented (with initials) by pharmacist prior to administration. 

0(7 = the number of all prescriptions/medication orders for high-alert medications. 

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An evaluation of the various studies reported in the literature for preclinical assessment of drugs for nasal administrations indicated the usefulness of in situ, ex vivo, and in vivo approaches. Evidence from the literature also indicates that the choice of a particular model or animal species by different... 

Later, a series of administration experiments with deuterium- and C-labeled phenylpropanoid monomers and elicitor-treated, (Z)-hinokiresinol-forming cultured cells of Asparagus officinalis were carried out [19]. GC-MS and NMR analyses of the (Z)-hinokiresinol isolated following the administration indicated that all carbon atoms of (Z)-hinokiresinol were derived from phenylpropanoid monomers... 

In a three-generation study of reproductive toxicity no effect was seen on fertility, viability, or litter size in rats fed dietary concentrations of 250ppm." A statistically significant increase in sperm abnormalities was seen in mice after oral administration of ferbam at lOOOmg/kg body weight per day for 5 days. No effects were seen after intraperitoneal administration, indicating that active metabolites were responsible for the teratospermia. 

Distribution - Zaleplon is a lipophilic compound with a volume of distribution of approximately 1.4 L/kg following IV administration, indicating substantial... 

Investigation by this Administration indicates your responsibility for violations of the Federal Food, Drug, and Cosmetic Act, and other Federal Laws, as described in the attached Charge Sheet, with respect to the following ... 

Adrenocorticotropin is a peptide hormone produced in the anterior pituitary. Its primary endocrine function is to stimulate synthesis and release of cortisol by the adrenal cortex. Corticotropin can be used therapeutically, but a synthetic derivative is more commonly—and almost exclusively—used to assess adrenocortical responsiveness. A substandard adrenocortical response to exogenous corticotropin administration indicates adrenocortical insufficiency. 

Mortality. Generally a mortality rate of 10% to 15% of a dose group due to test article administration indicates that a MTD has been achieved at that dose. 

Drug Trade Name Route Of Administration Indications... 

Mechanisms of action Actions mineralocorticoid, glucocorticoid Individual adrenal steroids Pharmacokinetics Dosage schedules Choice of adrenal steroid Adverse effects of systemic pharmacotherapy Adrenal steroids and pregnancy Precautions during chronic therapy treatment of intercurrent illness Dosage and routes of administration indications for use... 

The magnitude and duration of drug concentrations above MIC in respiratory secretions after aerosol administration indicate that mhalation therapy may be a suitable option for some bacterial infections of the lower respiratory tract. Pretreatment with a short-acting, aerosolized bronchodilator, such as albuterol sulfate, may improve the pulmonary distribution of aerosolized antimicrobial drugs. 

Route and condition of administration indicate if special precaution have to be taken during administration. 

Methadone has Food and Drug Administration indications for the management of pain in adults and for adult narcotic addiction. Adverse events are those expected from opiate exposures gastrointestinal symptoms, CNS depression, and respiratory depression in larger doses, bradycardia, and constipation. Methadone appears to be fairly well tolerated by... 

Aromatic EC>16-EC35 Fraction. Studies with animals exposed by inhalation, and by oral, dermal, or parenteral administration, indicate that PAHs are eliminated by urinary and biliary excretion of metabolites (ATSDR 1995f). 

Blood levels of fluoranthene, pyrene, and benz[a]anthracene after oral administration were examined in rats (Lipniak and Brandys 1993). Fluoranthene, pyrene, or benz[a]anthracene in Tween 80/isotonic saline, was administered orally to rats at a dose of 20 mg/kg. Blood levels after administration indicated that peak concentrations of the three compounds were reached at 1-2 hours after administration. The peak concentration of fluoranthene (- 30 mg/cm ) was twice as high as that of pyrene, and 5 times higher than benz[a]anthracene. 

Food and Drug Administration. Indication for Bendectin Narrowed. FDA Drug Bulletin. Vol. 11, Number 1, pgs. 1-2, March, 1981. 

Effects on other receptors are known (e.g., antimuscarinic and antihistaminic), but these appear to elicit mostly side effects. The hypothesis that arises—and may replace the biogenic amine concept partially—is that it may be the chronic exposure of central (32-adrenoreceptors to these elevated biogenic amines (NE, 5-HT, and maybe DA also) that is the basis of the action. The most likely effect now seems to be decreased sensitivity of these receptors. By measuring c-AMP levels, studies using long-term drug administration indicate that central (3-receptors become less responsive postsynaptically and also that central 5-HT and (Xi receptors may become enhanced. 

The LDjo values of dihydroxydihydroaldrin for rats are 1250 mg/kg (oral administration) and 51 mg/kg (intravenous administration) indicating that the living organism can detoxify insecticides belonging to the diene group. 

Drug Class/Agent Method of Administration Indications for Use... 

Clofazimine accumulates in certain tissues throughout the body (fatty tissue, skin, lymph nodes, macrophages etc.) and is eliminated very slowly. The kinetics of the drug has been described by both one and two compartment models. Data obtained with relatively low dose, short term administration indicated a one compartment model, with a a plasma tip of approximately 7 days (Levy, 1974 Hastings et al., 1976 Holdiness, 1989). A second compartment is evident with long term, high dose administration and appears to have a tip of at least 70 days (Banerjee et al., 1974 Levy, 1974). 

The plasma concentration of atropine sulphate and methylatropine which produce tachycardia in beagles is about OT pg/ml. The injection of atropine sulphate into the lateral ventricle is more effective in producing tachycardia than it is on subcutaneous administration indicating the alkaloid salt to be absorbed in the cerebral ventricles [179]. 

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