Adhesives tissue reaction

Side effects Side effects such as erosions, superficial ulceration or mucosal necrosis can be expected in > 80% of cases. Sucralfate, cimetidine, ranitidine and omeprazole (116) as well as fibrin adhesive have been used both for prevention and to promote healing. From a morphological viewpoint, these inflammatory tissue reactions are to a certain extent necessary to induce thrombosis and vessel wall fibrosis. Fever, leucocytosis, chest pain and tension occur as frequent yet usually insignificant concomitant reactions. Dysphagia or dysfunction of the oesophagus are of no clinical significance. The develop-... 

Before proceeding to the advanced technology area of biosensors, brief consideration goes to coatings of medical devices to improve performance and to prevent such adverse reactions as adhesion of the medical device to the tissues, bacterial adhesion, platelet adhesion and activation, and adverse tissue reaction of host to device from the standpoint of protecting both the host and the function of the device. 

Initial mechanical studies with methacrylated monomers show that these polymers demonstrate enhanced mechanical integrity, forming densely crosslinked networks. Moreover, they successfully polymerized in situ in a tibial bone defect, with good adhesion of the polymer to the cortical bone and medullary cavity, as well as minimal adverse tissue reaction to the photopolymerization reaction. ... 

Tris-acryl gel microspheres were the first spherical embolic agents to be commercially available [32]. Tris-acryl is an entirely synthetic, hydrophilic, and nonresorbable material. It has been demonstrated that this material produces non-toxic tissue reaction, thus allowing absorption and cellular adhesion [32]. Colored and non-colored tris-acryl gelatin microspheres (Embogold and Embosphere Microspheres Biosphere Medical, Rockland, MA) are currently commercially available. 

Woerly, S., Laroche, G., Marchmd, R., Pato, J., Subr, V., md Ulbrich, K., Intracerebral implantation of hydrogel-coupled adhesion peptides tissue reaction, J. Neural Transplant Blast. 5, 245-255, 1995. 

Histamine contributes to the progression of allergic-inflammatory responses by enhancement of the secretion of proinflammatory cytokines like IL-la, IL-1(3, IL-6 as well as chemokines like RANTES or IL-8, both in several cell types and local tissues [26-29]. Endothelial cells express functional HRl and HR2 and increased adhesion molecule expression such as ICAM-1, VCAM-1 and P-selectin was demonstrated by histamine infusion via HRl [30-32]. Histamine regulates the expression of its own receptors on endothelial cells and influences the overall inflammatory reaction [33]. 

Scrolled-form fibers, eapillary whiskers, and the cage-framework zeolitic fibers offer not only large surface area, but sites for intrafibrillar reactions. These additional sites for adhesion are advantageous for special applications such as the use of fibers in filtration and in the eonstruction of composites. In faet, the synthetic composites most resemble bone, the tissue in which strength and resiliency are essential. It is not surprising that fibers will continue to be much used in our teehnologicaUy oriented society. 

Used for ocular bums as soon as 1947 by Sorsby [30], the amniotic membrane is a tissue located at the interface of the placenta and the amniotic fluid. It is constituted of an unstratifled epithelium, a basement lamina, and an avascular mesenchyma. The amniotic membrane facilitates the reepithelialization by reducing the inflammatory and cicatricial reaction [31]. It helps the migration of the epithelial cells and the adhesion of the basement cells [32]. It behaves as an actual replacing basement membrane and facilitates the phenotypic... 

These processes depend on chemotactic activation of the effector cells and altered cellular migration to promote an allergic reaction. During these events, there is also an upregulation of the adhesion molecules, both on the effector cells and on high endothelial venules in blood vessels, lungs and other tissues. 

It is often demanded that the surface of polymeric biomaterials should exhibit permanent tenacious adhesion to soft connective and dermal tissues. However, conventional non-porous, polymeric materials will be encapsulated by a fibrous membrane generated de novo by surrounding fibroblasts, when subcutaneously implanted into the living body in contact with soft connective tissues. This is a typical foreign body reaction of the living system to isolate foreign materials from the host inside the body. On the other hand, it should be noted that the small gap present between a percutaneously-implanted device and the surrounding tissue provides a possible route for bacterial infection because of the lack of microscopic adhesion at the interface. 

Although the cellular and molecular mechanisms underlying fibrosis are not fully explained, it is assumed that an inflammatory reaction is the initiating factor in the early stage of fibrosis and that this inflammatory process continues during the fibrotic process [77, 105, 106], Kupffer and endothelial cells are considered to be the most important resident cells involved in the local production of inflammatory mediators [24, 28, 29, 76], Besides causing the activation of HSC, the inflammatory mediators induce the expression of adhesion molecules, such as ICAM-1 and VCAM on endothelial cells, that direct neutrophils and monocytes into the inflamed liver tissue [41-43], Expression of adhesion molecules is also shown for KC and stellate cells [42, 107], Furthermore, chemotactic compounds are released by endothelial and KC to attract immune competent cells... 

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