Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Adenylic acid muscle

Adenylic Acid. Muscle adenylic acid ergaden -ylic acid t -adenylic acid adenosine S -monophosphate adenosine phosphate adenosine-5 -phosphoric add edeno-sine-5. monophosphoric acid A5MP AMP NSC-20264 Addiyl Cardiomone (Na salt) Lycedan My -B-Den My-oston Phosaden. C,0HhNjO7P mol wt 347.23, C 34.59%, H 4.06%, N 20.17%, O 32,25%, P 8,92%. Nucleotide widely distributed in nature. Prepn from tissues Embden, Zimmerman, Z. Physrot Chem. 167, 137 (1927) Embden, Schmidt, ibid. 181, 130 (1929) cf. Kalckar, J. B.ol Chem. 167, 445 (1947). Prepn by hydrolysis of ATP with barium hydroxide Kerr, 3. Biot Chem. 139, 13l (1941). Synthesis Baddiley, Todd. 3. Chem. Soc. 1947, 648. Commercial prepn by enzymatic phosphorylation of adenosine. Monograph on synthesis of nucleotides G. R. Pettit. Synthetic Nucleotides vol, 1 (Van Nostrand-Reinhold. New York, 1972) 252 pp. Crystal structure Kraut, lensen, Acta Cryst 16, 79 (1963). Reviews see Adenosine Nucleic Acids. [Pg.26]

The bearing which these discoveries have had on the elucidation of the structure of ribopolynucleotides will be discussed later. It is important to stress here, however, that, for most purposes, the older methods of preparing nucleotides have been superseded by procedures which yield separate isomers of each. Of the techniques mentioned above, paper chromatography iB mainly of analytical value, and is the most convenient method for the qualitative detection of isomeric adenylic acids. The only disadvantage of this method is that the isomers are not completely separable from muscle adenylic acid. The presence of the latter, however, can be readily detected by hydrolyzing it to adenosine by means of the specific 5-nucleotidase present in snake venoms,66 or by deamination by a specific enzyme... [Pg.295]

The isomerism existing between the pairs of nucleotides was attributed to the different locations of the phosphoryl residues in the carbohydrate part of the parent nucleoside,49 63 since, for instance, the isomeric adenylic acids are both hydrolyzed by acids to adenine, and by alkalis or kidney phosphatase to adenosine. Neither is identical with adenosine 5-phosphate since they are not deaminated by adenylic-acid deaminase,68 60 and are both more labile to acids than is muscle adenylic acid. An alternative explanation of the isomerism was put forward by Doherty.61 He was able, by a process of transglycosidation, to convert adenylic acids a" and 6 to benzyl D-riboside phosphates which were then hydrogenated to optically inactive ribitol phosphates. He concluded from this that both isomers are 3-phosphates and that the isomerism is due to different configurations at the anomeric position. This evidence is, however, open to the same criticism detailed above in connection with the work of Levene and coworkers. Further work has amply justified the original conclusion regarding the nature of the isomerism, since it has been found that, in all four cases, a and 6 isomers give rise to the same nucleoside on enzymic hydrolysis.62 62 63 It was therefore evident that the isomeric nucleotides are 2- and 3-phosphates, since they are demonstrably different from the known 5-phosphates. The decision as to which of the pair is the 2- and which the 3-phosphate proved to be a difficult one. The problem is complicated by the fact that the a and b" nucleotides are readily interconvertible.64,64... [Pg.296]

The existence of two separate enzymes in animal tissues responsible for the liberation of ammonia from each of the two aminopurines, adenine and guanine, the latter specific for the free purine and the former for the nucleosides, was initially presented by Jones and his colleagues 11, 12). In 1928, Schmidt 13-15) demonstrated that AMP aminohy-drolase was responsible for the appearance of inosinic acid in muscle and for at least a portion of ammonia liberated during contraction. He showed not only a marked specificity for deamination of 5 -AMP but also provided the first clue that muscle adenylic acid (5 -AMP) and yeast adenylic acid (3 -AMP) were different compounds. Initial evidence for guanine and adenosine aminohydrolase including aspects of the specificity were also described by Schmidt 16). Additional details regarding development of interest in purine aminohydrolases are available in several excellent reviews 17-20). [Pg.48]

The enzyme adenylic acid deaminase catalyzes the deamination of AMP to IMP and ammonia. For the HPLC method, the assay involves the separation of the substrate, AMP, from the reaction product IMP. The enzyme is found in muscle. [Pg.317]

ADENOSINE PHOSPHATE ADENOSINE-5 -PHOSPHATE ADENOSINE-5 -PHOSPHORIC ACID ADENOVITE ADENYL ADENTT.IC ACID tert-ADENYLIC ACID A5MP 5-AMP 5 -AMP AMP (nucleotide) CARDIOMONE ERGADENYLIC ACID LYCEDAN MUSCLE ADENYLIC ACID MY-B-DEN MYOSTON NSC-20264 PHOSADEN PHOSPHADEN PHOSPHENTASIDE... [Pg.77]

Muscle Adenylic Acid (5-Phospho-adenosine). Embden discovered in muscle extracts an adenylic acid which has since been isolated from heart muscle and from the brain. Since it was already known that an... [Pg.212]

In confirmation of this structure, Klimek and Parnas found that muscle adenylic acid forms a complex with boric acid. Such a complex has been shown by Boeseken to be formed only by polyhydroxy compounds having two adjacent ds hydroxyl groups. [Pg.213]

Properties (Muscle adenylic acid) crystalline solid. Mp 196-200C. Readily soluble in boiling water. Gives only traces of furfural when boiled with 20% hydrochloric acid. [Pg.25]

Derivation From meat extract or by enzymatic deamination of muscle adenylic acid. [Pg.690]

Inosinic acid (1), the first nucleotide to be discovered, was isolated over a century ago from beef extract by Liebig. Mild, acid hydrolysis of this nucleotide yielded a ribose phosphate (2) which, by oxidation with nitric acid, gave a ribonic acid phosphate (3), but not a ribaric acid phosphate. These studies by Levene and his associates showed that the phosphoric (phospho) group is bound to the 5-hydroxyl group of the ribosyl moiety in 1 hence, inosinic acid is inosine 5 -phosphate. Adenylic acid (4), isolated from muscle, was converted enzymically (by adenylic... [Pg.309]

Japan, pat. 732C86) (to Ajinomoto), C.A. 51, 3870b (1957). Structure Levene, Bess, op. ctt.. pp 187-192 Bredereck, Ber. 66, 198 (1933) Levene, Tipson, J. Biol. Chem. Ill, 3t3 (1935). Also prepd from muscle by enzymatic deamination of muscle adenylic acid Ostem, Biochem. Z. 254, 63 (1932) by hydrolysis of inosine triphosphate Kleinzeller, Biochem. J. 36, 729 (1942). Studies on the enzymatic synthesis Greenberg, J. Biol. Chem. 198, 611 (1951) Korn et al, ibid 217, 875 (1955). Microbial fermentation method using mutant strains of Micrococcus glutamicus Kinoshita el al. U.S. pat. 3,232,844 (1966 to Kyowa). [Pg.788]


See other pages where Adenylic acid muscle is mentioned: [Pg.322]    [Pg.322]    [Pg.322]    [Pg.331]    [Pg.322]    [Pg.322]    [Pg.322]    [Pg.331]    [Pg.15]    [Pg.294]    [Pg.294]    [Pg.306]    [Pg.82]    [Pg.148]    [Pg.148]    [Pg.56]    [Pg.322]    [Pg.333]    [Pg.1791]    [Pg.213]    [Pg.286]    [Pg.310]    [Pg.14]    [Pg.1008]    [Pg.213]   
See also in sourсe #XX -- [ Pg.22 , Pg.309 ]

See also in sourсe #XX -- [ Pg.212 , Pg.213 ]

See also in sourсe #XX -- [ Pg.309 ]

See also in sourсe #XX -- [ Pg.212 , Pg.213 ]




SEARCH



Adenylate

Adenylation

Adenylic acid

Muscle-adenylic acid deaminase

© 2024 chempedia.info