Urinary bladder adenocarcinoma

Because evidence of carcinogenicity in mice (leiomyosarcoma in the urinary bladder, lymphoblastic lymphosarcoma and leukemia, and bronchiolar-alveolar adenocarcinoma and adenoma) was obtained from a single study, it is considered that there is limited evidence of carcinogenicity effects, which deserves a classification Category 2-H350 according to CLP criteria [63],... 

Chronic study (mouse) Mammary gland adenocarcinoma, liver necrosis, urinary bladder hyperplasia (640 mg kg-1 per day) Kidney lesions (62.5 mg kg-1 per day)... 

Primary adenocarcinomas of the lung are typically CK7-F, CK20-, and CEA-f, whereas colorectal carcinomas are CK7-, CK20-F, and CEA-i- ductal and lobular breast carcinomas are CK7-f, CK20-, and often CEA-I- and ovarian carcinomas are CK7-I-, CK20 , and CEA-.121,125-129,224-227 Neoplasms that typically are strongly positive for most CEA antibodies include adenocarcinomas of the lung, colon, stomach, biliary tree, pancreas, urinary bladder, endocervix, paranasal... 

Adenocarcinomas of urinary bladder (urachal origin) are CDX2-I- but are also positive for thrombomodulin and CK7, whereas colorectal carcinomas are negative with thrombomodulin and CK7 and have nuclear beta-catenin expression. 

True hepatocellular carcinoma differentiation (polyclonal CEA-I-, HepPar-l-i-, sinusoidal cell CD34-f) has been described on rare occasions as a component of some adenocarcinomas from urinary bladder and stomach. Hepatoid carcinomas as components of ovarian tumors regularly express significant HepPar-1. ... 

Sinard J, Macleay Jr L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer. 1994 73 1919-1925. 

TTF-1. Also, 11% of lung adenocarcinomas detected by Nap-A were missed by TTF-1 staining. The authors concluded that Napsin A was a valuable marker for detecting lung adenocarcinomas versus other adenocarcinomas such as those from the breast, colon, biliary tract, pancreas, urinary bladder, and ovary. It was less useful in distinguishing primary pulmonary adenocarcinomas from thyroid carcinomas and renal carcinomas. 

Lopez-Beltran A, Luque RJ, Quintero A, et al. Hepatoid adenocarcinoma of the urinary bladder. Virch Arch. 2003 442 381-387. 

FIGURE 16.25 Rectal adenocarcinoma secondarily involving urinary bladder (A and B). The tumor is CK20+, CK7-, CDX2+, and as shown in C to F, respectively. 

Lane Z, Hansel DE, Epstein JI. Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. Am J Surg Pathol. 2008 32 1322. 

Grignon DJ, Ro JY, Ayala AG, et al. Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases. Cancer. 1991 2165 67. 

Epstein JI, Kuhajda FP, Lieberman PH. Prostate-specific acid phosphatase immunoreactivity in adenocarcinomas of the urinary bladder. Hum Pathol. 1986 17 939. 

Raspollini MR, Nesi G, Baroni G, et al. Immunohistochemistry in the differential diagnosis between primary and secondary intestinal adenocarcinoma of the urinary bladder. Appl Immuno-histochem Mol Morphol. 2005 13 358. 

Jacobs LB, Brooks JD, Epstein JI. Differentiation of colonic metaplasia from adenocarcinoma of urinary bladder. Hum Pathol. 1997 28 II52. 

Silver SA, Epstein JI. Adenocarcinoma of the colon simulating primary urinary bladder neoplasia. A report of nine cases. Am J Surg Pathol. 1993 17 171. 

Gastric adenocarcinoma, GIT carcinoids, islet pancreas tumors, mucinous adenocarcinomas of ovary, bronchoalveolar carcinomas of lung, adenocarcinomas of urinary bladder... 

Carcinoma of the urinary bladder represents the sixth most common cancer in the United States comprising 2% of the patients with malignant disease, and the second most frequent neoplasm in the genitourinary tract. The American Cancer Society estimated that in the year 2001 there would be about 54,300 new cases of bladder cancer diagnosed in the United States (39,200 men 15,100 women), twice the incidence in whites than blacks. Approximately 12,400 patients would succumb to bladder cancer (8,300 men 4,100 women). Of all bladder tumors, 97% are epithelial in origin, 90% TCC, 6%-7% squamous cell carcinoma, and l%-2% adenocarcinoma. It is beheved that most cases result from exposure to environmental carcinogens, the most important of which is cigarette smoke. 

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