Nuclear beta-catenin

Fischer AN, Fnchs E, Mikula M, Huber H, Beug H, Mikulits W (2006). PDGF essentially links TGF beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene [Epub ahead of print]. 

Bhattacharya B, Dilworth HP, lacobtrzio-Donahue C, et al. Nuclear beta-catenin expression distingirishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol. 2005 29 653-659. 

Adenocarcinomas of urinary bladder (urachal origin) are CDX2-I- but are also positive for thrombomodulin and CK7, whereas colorectal carcinomas are negative with thrombomodulin and CK7 and have nuclear beta-catenin expression. 

Ng TL, Gown AM, Barry TS, et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol. 2005 18 68-74. 

Jung CK, Jung JH, Lee A, et al. Diagnostic use of nuclear beta-catenin expression for the assessment of endometrial stromal tumors. Mod Pathol. 2008 21 756-763. 

Yamazaki K, Hanami K, Nagao T, Asoh A, Sugano I, Ishida Y. Increased cyclinDl expression in cancer of the ampula of Vater relevance to nuclear beta-catenin accumulation and K-ras gene mutation. Mol Pathol. 2003 56 336-41. 

Stucke VM, Corses D, Hofmann F (2008) DEAD-box RNA helicase p68 is not required for nuclear translocation of beta-catenin in colon cancer cells. Cell Cycle 7 830-832... 

Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J. Cell. Biol. 2001 153 1161-1174. Yang Y, Guo L, Blattner SM, Mundel P, Kretzler M, Wu C. Formation and phosphorylation of the PINCH-l-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podoc)4e adhesion, architecture, and survival. J. Am. Soc. Nephrol. 2005 16 1966-1976. 

FIGURE 4.2 Nuclear labeling for beta-catenin is typical of deep fibromatosis. 

Eew studies have been done on the molecular features of gastrointestinal endocrine tumors. Allelic loss of llq has been detected in GI endocrine tumors associated with MENl, and LOH of 1 Iq is also present in a subset of sporadic GI endocrine tumors. Mutations of the MENl gene are present in approximately 30% of sporadic gastrinomas and in occasional midgut and hindgut endocrine tumors. In contrast to pancreatic endocrine tumors, the CpG island methylator phenotype is frequent in GI endocrine tumors. Beta-catenin exon 3 mutations are relatively common (38%) in these tumors, and up to 80% of the tumors show nuclear and cytoplasmic localization of the corresponding protein. Other studies, however, reported absence of exon 3 mutations, but nuclear f5-catenin was found in 30% of cases. In contrast, extra-GI endocrine tumors were negative for nuclear f5-catenin. 

Garcia-Rostan G, Camp RL, Herreo A, et al. Beta catenin dys-regulation in thyroid neoplasms Down regrrlation, aberrant nuclear expression, and CTNNBl exon 3 mutations are markers for aggressive trrmor phenotypes and poor prognosis. Am J Pathol. 2001 158 987-996. 

Su MC, Wang CC, Chen CC, et al. Nuclear translocation of beta-catenin and APC mutation in gastrointestinal carcinoid tumor. Ann Surg Oncol. 2006 13 1604-1609. 

SOLITARY FIBROUS TUMOR AND PSEUDOTUMOR Solitary fibrous tumors infrequently arise in the upper abdomen and mesentery.350.375-377 They are positive with CD34, CD99, and smooth muscle actin but do not stain with CD 117.350.368,378 Also, approximately 25% of solitary fibrous tumors stain with beta-catenin in a nuclear pat-tern.3 3 Nodular fibrous pseudotumors are rare lesions in this location. They share strong GDI 17 reactivity with GISTs however, they are morphologically distinct from GISTs. 

Saito T, Oda Y, Tanaka K, et al. beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours. J Pathol. 2001 195 222-228. 

Tanaka Y, Kato K, Notohara K, et al. Significance of aberrant (cytoplasmic/nuclear) expression of beta-catenin in pancreatoblastoma. J Pathol. 2003 199 185-190. 

Kim MJ, Jang SJ, Yu E. Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immuno-profiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas. Hum Pathol. 2008 39 251-258. 

Haydon RC, Deyrup A, Ishikawa A, et al. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer. 2002 102 338-342. 

Saegusa M, Hamano M, Kuwata T, et al. Up-regulation and nuclear localization of beta-catenin in endometrial carcinoma in response to progesterone therapy. Cancer Sci. 2003 94 103-... 

Williams, J.L., Nath, N., Chen, J., Hundley, T.R., Gao, J., Kopelovich, L., Kashfi, K., and Rigas, B. (2003). Growth inhibition of human colon cancer cells by nitric oxide (no)-donating aspirin is associated with cyclooxygena.se-2 induction and beta-catenin/t-cell factor signahng, nuclear factor-kappab, and no synthase 2 inhibition Implications for chemoprevention. Cancer Res. 63, 7613-7618. 

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