Rectal adenocarcinoma

Conclusions drawn from in vitro cell studies with heavy ion beams of varying LET have indicated that approximately 100 keV /tm" was optimal in achieving a maximum relative biological effect (R6E), as demonstrated by the blocking of cells in Gj -1- M and subsequent lethal effects (21,96,97). The efficient arrest of cultured human squamous cell carcinoma of the larynx (HEp2) and murine rectal adenocarcinoma... 

Steele GD, Herndon JE, Bleday R, et al. Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann Surg Oncol 1999 6 433 -41. 

Marsh RD, Chu NM, Vauthey JN, et al. Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy. Cancer 1996 78(2) 217-225. 

Ramalingam P, Hart WR, Goldblum JR. Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. Arch Pathol Lab Med. 2001 125 1074-1077. 

FIGURE 16.25 Rectal adenocarcinoma secondarily involving urinary bladder (A and B). The tumor is CK20+, CK7-, CDX2+, and as shown in C to F, respectively. 

Zhang PJ, Shah M, Spiegel GW, et al. Cytokeratin 7 immunoreactivity in rectal adenocarcinomas. Appl Immunohistochem Mol Morphol. 2003 11 306-310. 

Cetuximab-related tumor lysis syndrome occurred in a 60-year-old man with a moderately differentiated metastatic rectal adenocarcinoma [113 ]. 

Fig. 31.2a-c. MDCT perfusion of rectal adenocarcinoma. Axial MDCT perfusion is a noninvasive tool, providing functional information about tumor neovascularity, represented by blood volume (milliliter per 100 g wet tissue) (a), blood flow (milliliter per 100 g wet tissue per minute) (b), mean transit time (seconds), and permeability surface area (milliliter per 100 g wet tissue per minute) (c), that can be displayed as chromatic maps... 

Fig. 31.8a-l. MDCT of rectal adenocarcinoma before and after neoadjuvant chemoradiotherapy, a,b Axial and coronal MDCT of stenosing rectal cancer (arrow) before neoadjuvant chemo-radiotherapy. c-l see next page... 

Immunologic A 49-year-old man with metastatic rectal adenocarcinoma received cranial radiotherapy with prophylactic phenytoin 300 mg/day. He developed 10 with denudation of the skin of the face, torso, and extremities. Symptoms resolved with steroid treatment and cessation of phenytoin. This is the fifth reported case of 10 in the setting of concurrent radiotherapy and phenytoin [131 ]. Another case of phenytoin-induced 10 was reported in a 57-year-old woman receiving phenytoin prophylaxis after resection of a meningioma [132 ]. She recovered 10 days after withdrawal of phenytoin. 

Kurosaka, A., Nakajima, H., Funakoshi, I., Matsuyama, M., Nagayo, T, and Yamashina, I., 1983, Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein, J. Biol. Chem. 258 11594-11598. 

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