Anemia, acute hemolytic

The answers are 484-k 485-j. (tlardman, pp 1061-1062, 1682-1685.) Sulfonamides can cause acute hemolytic anemia. In some patients it mayr be related to a sensitization phenomenon, and in other patients the hemolysis is due to a glucose-6-phosphate dehydrogenase deficiency Sulfamethoxazole alone or in combination with trimethoprim is used to treat UTls. The sulfonamide sulfasalazine is employed in the treatment of ulcerative colitis. Daps one, a drug that is used in the treatment of leprosy, and primaquine, an anti mala rial agent, can produce hemolysis, particularly in patients with a glucose-6-phosphate dehydrogenase deficiency. 

OSHA (Occupational Safety and Health Administration). 1999. OSHA Chemical Sampling Information. ChemSamp. [On-line] Available http //www.osha-slc.gov/ ChemSamp data. Pemis, B., and M.Magistretti. 1999. A study of mechanisms of acute hemolytic anemia from arsine. Med. Lavaro 51 37-41. 

Dl. Dawson, J. P., Thayer, W. W., and Desforges, J. F., Acute hemolytic anemia in the newborn infant due to naphthalene poisoning Report of two cases with investigations into the mechanism of the disease. Blood 13, 1113-1125 (1958). 

H21. Houston, I. B., and Barlow, A. M., Acute hemolytic anemia and methemo-globinuria produced by phenacetine. Lancet ii, 1062-1005 (1959). 

Although unlikely in an occupational setting, ingestion of copper salts may cause vomiting, abdominal pain, diarrhea, lethargy, acute hemolytic anemia, renal and liver damage, neurotoxicity, increased blood pres-... 

Hemolytic anem/a. Acute hemolytic anemia, including cases resulting in death, has been reported in patients treated with indinavir. 

Anemia Acute hemolytic anemia has occurred in a patient treated with amprenavir. Diabetes mellitus/hyperglycemia New-onset diabetes mellitus, exacerbation of pre-existing diabetes mellitus, and hyperglycemia have been reported during postmarketing surveillance in HIV-infected patients receiving protease inhibitor therapy. 

Skin reactions Severe or life-threatening skin reactions, including Stevens-Johnson syndrome, were reported in less than 1% of patients treated with fosamprenavir in the clinical studies. Discontinue treatment with fosamprenavir for severe or life-threatening rashes and moderate rashes accompanied by systemic symptoms. Hemolytic anem/a.-Acute hemolytic anemia has been reported. 

The sulfones can produce nonhemolytic anemia, methemoglobinemia, and sometimes acute hemolytic anemia in persons with a glucose-6-phosphate dehydrogenase deficiency. Within a few weeks of therapy some... 

The most common adverse effects of indinavir are indirect hyperbilirubinemia and nephrolithiasis due to crystallization of the drug. Nephrolithiasis can occur within days after initiating therapy, with an estimated incidence of approximately 10%. Consumption of at least 48 ounces of water daily is important to maintain adequate hydration. Thrombocytopenia, elevations of serum aminotransferase levels, nausea, diarrhea, insomnia, dry throat, dry skin, and indirect hyperbilirubinemia have also been reported. Insulin resistance may be more common with indinavir than with the other Pis, occurring in 3-5% of patients. There have also been rare cases of acute hemolytic anemia. 

As illustrated in case 1, acute hemolytic anemia occurs when there is destruction of the G6PD-deficient red cells. The fact that the most... 

Nomifensine was first introduced in 1977 and eventually became available in over 70 countries. There has been increasing evidence of problems with adverse effects since 1981 (SEDA-5, 19), when cases of drug fever were recorded (SEDA-10, 22) this vague term covers a multitude of sins, the origins of which were finally elucidated at almost the exact moment when nomifensine was approved for release in the USA. Finally, in January 1986, the manufacturers withdrew nomifensine worldwide, citing grave concern elicited particularly by cases of rapid acute hemolytic anemia with intravascular hemolysis (SEDA-10, 22) (1). 

Acute hemolytic anemia, probably as part of an allergic reaction (SED-9, 154) (4,5), leukopenia through an unknown mechanism, and thrombocytopenic purpura with hemorrhage have been documented (6). 

The use of silver sulfadiazine has been associated with acute hemolytic anemia (22). 

Starzl T. Acute hemolytic anemia in liver and bone marrow transplant patients under FK 506 therapy. Transplant Proc 1991 23(6) 3190-2. 

There are no reported cases of death due to inhalation of naphthalene. Naphthalene-induced deaths are usually related to mothball ingestion during suicide attempts. Based on suicide data, the lethal dose in humans is estimated to range from 319 to 574 mg kg The most prominent effect of high-dose naphthalene exposure in humans is hemolytic anemia. There is a report of an infant who died of acute hemolytic anemia after being exposed to... 

Accidental and intentional ingestions have resulted in headache, deafness, blindness, tachycardia, respiratory arrest, and death. Reversible renal failure can occur. The adult toxic dose can be as low as 2g. Death from intentional or accidental overdose generally follows renal failure, acute hemolytic anemia, and respiratory arrest. 

Grudeva-Popova J, Spasova M, Chepileva K, Zapri-anov Z. Acute hemolytic anemia as an initial chnicai manifestation of Wilson s disease. Folia Med (Plovdiv) 2000 42 42-6. 

Schafer WB. 1951. Acute hemolytic anemia related to naphthalene Report of a case in a newborn infant. Pediatrics 172-174. 

Acute hemolytic anemia due to depletion of erythrocyte glutathione, causing RBC membrane instability... 

Partial List of Drugs and Chemicals That Cause Acute Hemolytic Anemia in Persons with G6PD Deficiency... 

Acute hemolytic anemia has been reported in ponies by Paradis et al.32 by oral administration of tryptophan. 

These compounds were extensively used in the 40 s through the 60 s to treat pulmonary and other systemic infections. Reports of acute renal failure, most secondary to crystalluria were common [1-3]. Rarely, the sulfonamides can cause acute interstitial nephritis, necrotizing arteritis or hemoglobinuric acute renal failure due to massive acute hemolytic anemia [4, 6]. 

Hemopoietic effects acute hemolytic anemia, accompanied by renal failure, e.g., after inhalation of arsenic hydride or ingestion of soluble copper salts. 

Manzler ad and Schreiner AW (1970) Copper-induced acute hemolytic anemia a new complication of hemodialysis. Ann Intern Med 73 409-412. 

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