Acute renal failure hemoglobinuric

Corwin HL, Schreiber MJ, Fang LS. Low fractional excretion of sodium. Occurrence with hemoglobinuric and myoglobinuric-induced acute renal failure. Arch Intern Med 1984 144 981-982. 

These compounds were extensively used in the 40 s through the 60 s to treat pulmonary and other systemic infections. Reports of acute renal failure, most secondary to crystalluria were common [1-3]. Rarely, the sulfonamides can cause acute interstitial nephritis, necrotizing arteritis or hemoglobinuric acute renal failure due to massive acute hemolytic anemia [4, 6]. 

Provide vigorous intravenous hydration and, if needed, osmotic diuresis with mannitol (see p 464) to maintain urine output and reduce the risk of acute hemoglobinuric renal failure. 

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