Acetamide, N-Methyl

N,N-Dimethylacetamide 100 mmol N-methyl acetamide/mol creatinine in urine (HGV) Post shift... 

Modified amino acids such as N-acyl-dehydroalanine polymers and copolymers with N-vinyl-N-methyl acetamide seem to be particularly effective [396]. The crystallization kinetics in the presence of polyvinylpyrrolidone and tyrosine have been tested by time-resolved experiments [981]. An influence is evident on the particle size distribution of the hydrate [1433]. 

Cheam, T. C., and S. Krimm. 1985. Infrared Intensities of Amide Modes in N-methyl-acetamide and Poly(Glycine I) From Ab Initio Calculations of Dipole Moment Derivatives of N-methylacetamide. J. Chem. Phys. 82, 1631-1641. 

Fig. 7.19 Illustration of the additivity of conformational geometry functions for the -ro-tation in (CH3CO)(H)N-C(CH3)(H)(CONHCH3) (ALA). During the torsional motion about the N-C(a) bond of ALA, the interactions within the system are the same as those encountered during the N-C torsion in N-ethyl acetamide (NEA), plus those encountered during the N-C(a) torsion in N-acetyl N -methyl glycine amide offset by 120° as shown (GLY), minus those encountered during the N-C torsion in N-methyl acetamide (NMA).

Alternatively, dissolve 220 g 4-benzyloxy-3-indoleacetic acid (or equimolar amount other indoleacetic acid) in 2 L absolute methanol and reflux six hours in the presence of 20 g Dowex 50X8 sulfonic acid resin. Filter (decolor with carbon if desired) and concentrate below 35° until precipitation starts then cool to precipitate and filter to get 200 g of the methyl ester. Add 200 g of the ester to 600 ml 40% aqueous methylamine over twelve hours with vigorous stirring. Filter, wash precipitate with water and dry to get 187 g of the N-methyl-acetamide (reflux two hours in 500 ml benzene to remove unreacted ester). 24 g of the acetamide in 300 ml tetrahydrofuran is added dropwise to 10 g lithium aluminum hydride in 300 ml tetrahydrofuran reflux ten hours, cool to 15° and add dropwise with stirring 50 ml ethyl acetate. Reflux two hours and proceed as above to get 15 g (II) or analog. 

The range of products formed on gamma radiolysis of N-acetylglycine was similar to that formed on radiolysis of the aliphatic carboxylic acids, but there are some noticeable differences in the yields of products. Carbon dioxide is by far the major volatile product of radiolysis and the corresponding product of the decarboxylation reaction, N-methyl acetamide, is also present in large yield, but the yield of this product was not quantitatively determined. By contrast, carbon monoxide is found in very small yield. The yield of acetamide, the product of N-Ca bond scission, is found in much greater yield. 

Finally, IR173), NMRl74 UV175 and Raman spectroscopy175) show that the cis conformation of N-methyl formamide and N-methyl acetamide is more stable than the tram. 

In ahnlicher Weise erhalt man durch Friedel-Crafts-Reaktion von beispielsweise Toluol mit N-Chlormethyl-N-methyl-acetamid N-Methyl-N- (4-methyl-benzyl)-acetamid, das sich zu Methyl-(4-methyl-benzyl)-amin deacetylieren laBt2 ... 

The solvents used for electroanalytical determinations vary widely in their physical properties liquid ranges (e.g., acetamide, N-methyl-acetamide and sulfolane are liquid only above ambient temperatures), vapour pressures (Table 3.1), relative permittivities (Table 3.5), viscosities (Table 3.9), and chemical properties, such as electron pair and hydrogen bond donicities (Table 4.3), dissolving ability of the required supporting electrolyte to provide adequate conductivity, and electrochemical potential windows (Table 4.8). A suitable solvent can therefore generally be found among them that fits the electroanalytical problem to be solved. 

Cieplak P, Caldwell J, Kollman P (2001) Molecular mechanical models for organic and biological systems going beyond the atom centered two body additive approximation aqueous solution free energies ofmethanol and n-methyl acetamide, nucleic acid base, and amide hydrogen bonding and chloroform/water partition coeficients of the nucleic acid bases. J Comput Chem 22 1048-1057... 

Multidimentional nonlinear infrared spectroscopy is used for identification of dynamic structures in liquids and conformational dynamics of molecules, peptides and, in principle, small proteins in solution (Asplund et al., 2000 and references herein). This spectroscopy incorporates the ability to control the responses of particular vibrational transitions depending on their couplings to one another. Two and three-pulse IR photon echo techniques were used to eliminate the inhomogeneous broadening in the IR spectrum. In the third-order IR echo methods, three phase-locked IR pulses with wave vectors kb k2, and k3 are focused on the sample at time intervals. The IR photon echo eventually emitted and the complex 2D IR spectrum is obtained with the use of Fourier transformation. The method was applied to the examination of vibrational properties of N-methyl acetamid and a dipeptide, acyl-proline-NH2.in D20. The 2D IR spectrum showed peaks at 1,610 and 1, 670 cm 1, the two frequencies ofthe acyl-proline dipeptide. Geometry and time-ordering of the incoming pulse sequence in fifth-order 2D spectroscopy is shown in Fig. 1.3. 

In general,classical vibrational analysis has been concerned with small molecules. E.g. - a typical amide might be N-methyl-acetamide[l2] ... 

P. Cieplak and P. Kollman, /. Comput. Chem., 12, 1232-1236 (1991). On the Use of Electrostatic Potential Derived Charges in Molecular Mechanics Force Field. The Relative Solvation Free Energy of Cis- and Tri2ws-N-Methyl-Acetamide. 

Mechanical Models for Organic and Biological Systems Going Beyond the Atom Centered Two Body Additive Approximation Aqueous Solution Free Energies of Methanol and N-Methyl Acetamide, Nucleic Acid Base, and Amide Hydrogen Hydrogen Bonding and Chloroform/Water Partition Coefficients of the Nucleic Acid Bases. 

C5H9F 1-fluoro-2-methyl-cis-2-butene 66213-76-1 317.11 26.763 2 5218 C5H9N02 N-acetyl-N-methyl acetamide 1113-68-4 468.15 40.833 1,2... 

C3H7NO N-methyl acetamide 79-16-3 6.830E-K09 47.120 3319 C4H8 cyclobutane 287-23-0 5.400E+09 40.920... 

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