Acesulfame Potassium

Acesulfame K E950 6-methyl-3,4-dihydro-l,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt Sunett-, Sweet One. 

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations, and as a toothpaste sweetener.  

The approximate sweetening power is 180-200 times that of sucrose. It enhances flavor systems and can be used to mask some unpleasant taste characteristics. 

Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste. 

Excipient Acesulfame potassium Magnification 150x Voltage 5 kV 

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Acesulfame potassium Aspartame Fructose Invert sugar... 

Acesulfame potassium is a noncaloric sweetener that is two hundred times sweeter than sugar. It is used in tabletop sweeteners, toothpastes, soft drinks, desserts, baked goods, and canned foods. 

Acesulfame potassium is used with other sweeteners such as aspartame because it has a long shelf life, and tastes sweet right away. It also has a synergistic effect with other sweeteners, so less of each is necessary to achieve the same sweetness. 

Acesulfame potassium Aspartame Saccharin Saccharin sodium Sodium cyclamate... 

Kaletra oral solution is available for oral administration as 80 mg lopinavir and 20 mg ritonavir per milliliter with the following inactive ingredients acesulfame potassium, alcohol, artificial cotton candy flavor, citric acid, glycerin, high fructose com symp, Magnasweet-110 flavor, men-... 

Acesulfame potassium 200 1 3.7 in water May decompose after long-term storage at 40° C 15 mg/kg of body weight... 

Acesulfame potassium Sweetener Kaolin Drying agent... 

Acesulfame Potassium occurs as a white, free-flowing crystalline powder. It is freely soluble in water and very slightly soluble in ethanol. 

Procedure (See Chromatography, Appendix IIA.) Use a high-performance liquid chromatograph capable of separating acesulfame potassium and 4-hydroxybenzoic acid ethyl ester with a resolution of 2. Use a chromatograph equipped with a UV or diode array (227 nm) detector and a 25-cm x 4.6-mm (id) stainless steel column, or equivalent, packed with 3 to 5 p,m of reversed phase C18 silica gel, or equivalent. The elution is isocratic. Use a 40 60 (v/v) solution of acetoni-trile 0.01 MlL tetrabutyl ammonium hydrogen sulfate (TBAHS) in water as the mobile phase, with a flow rate of about 1 mL/min. 

Inject 20 pL of Sample Solution into the chromatograph, and obtain the chromatogram. If peaks other than that caused by acesulfame potassium appear within three times the elution time of acesulfame potassium, carry out a second run using 20 p,L of Sample Solution diluted to 0.2 mg/L. 

The sum of the areas of all peaks eluted in the first run within three times the elution time of acesulfame potassium, except for the acesulfame potassium peak, does not exceed the peak area of acesulfame potassium in the second run. PH of a 1 100 Solution Determine as directed under pH Determination, Appendix IIB. 

Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0-3.5 at 20°C) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 40°C for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium. ... 

Acesulfame potassium is synthesized from acetoacetic acid tert-butyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium... 

An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed. 

The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight. ... 

Synergistic effects for combinations of sweeteners have been reported, e.g., acesulfame potassium with aspartame or sodium cyclamate. A ternary combination of sweeteners that includes acesulfame potassium and sodium saccharin has a greater decrease in sweetness upon repeated tasting than other combinations. ... 

A specification for acesulfame potassium is contained in the Food Chemicals Codex (FCC). 

Acesulfame potassium aspartame sodium sodium cyclamate. 

Synergistic effects for combinations of sweeteners have been reported, e.g., aspartame with acesulfame potassium. 

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