Academia authors

I have incurred many debts of gratitude to Prof E. J. Corey of Harvard University, who envisioned this project in the summer of 2002. What he once told me — The desire to learn is the greatest gift from God. —has been a true inspiration. Furthermore, it has been my greatest privilege as well as a pleasure to work with a stellar collection of contributing authors from both academia and industry. Some of them are world-renowned scholars in the field some of them have worked intimately with the name reactions that they have written some of them even took part in the discovery of the name reactions that they authored in this manuscript. As a consequence, this book truly represents the state-of-the-art for Name Reactions in Heterocyclic Chemistry. We will follow up with the second volume to complete the series on heterocyclic chemistry. 

Nevertheless, a certain process of focussing can be expected in the future. The authors expect that this process will give rise to two different groups of ionic liquids that will be routinely used throughout academia and industry. 

The objective of this volume is to provide an overview of the hit-to-lead process it is not intended to be all inclusive. Furthermore, much of the methodology described here is influenced by the culture of the authors respective institutions. In general, however, lead seeking approaches across industry (and academia) are more similar than they are different and are, for the most part, captured in this volume. 

This work was supported by the National Science Council of R.O.C. and Academia Sinica. The authors wish to thank Professors Fleming, Sundstrom, van Grondelle, and Yoshihara for helpful discussions. 

Under section 10 authority, EPA has a Chemical Substances Information Network (CSIN) prototype under test by industry, academia, unions and state government offices. The system is intended to permit easier access to existing data resources. 

When the potential content of this issue was initially discussed with the authors from industry and academia it was immediately clear that the various chapters should give a general overview, but should focus on developments of the last decade. After having finished the project we can state that this goal has been achieved. Thus, the reader will find a balanced view of basic knowledge and current progress. 

We would like to thank all of the authors for their valuable efforts in making this book serve as a definitive reference source on CE for laboratory analysts, researchers, managers/ executives in industry, academia, and government who are engaged in various phases of analytical research and development or in quality control. 

As the title page indicates, the two of us, the authors, come from different and at the same time complementing environments. One of us (M.P.) has been with industry and the other (M.S.), with academia for most of our respective carriers. This gave rise to the unique style and flavor of the book hereby presented to the reader. 

The author thanks Professors G. R. Waller and Otis C. Dermer for critically reviewing and editing this manuscript. This research was supported in part by the Academia Sinica, the National Science Council, and the Council of Agriculture of the Republic of China. The author is grateful to his former research assistants and graduate students for their diligent assistances. 

The focus of the present volume by Bernard Faller and Laszlo Urban is on methods and processes designed to predict drug-like properties, exposure and safety during hit and lead discovery. Distinguished authors from industry and academia discuss the current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. 

As a further activity the Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management (BMLFUW) in co-operation with the OECD organised an international conference in Vienna in November 2003, which was called "Experiences and Perspectives of Service-oriented Strategies in the Chemicals Industry and Related Areas". The conference was attended by around 100 participants from 16 countries. The conference gave an excellent overview about international approaches how to introduce service elements into the chemical business. The participants comprised representatives from authorities, the chemical industry, in particular down stream users, process engineers and economists along with representatives from academia. 

However, the ultimate reason is perhaps rooted in the Toxics Substances Control Act (TSCA). As it currently exists, the TSCA does not require chemical manufacturers to develop commercial chemicals that are safe, or to provide evidence of safety as a condition for marketing in the USA. If the TSCA were amended such that that it authorized the EPA to require that chemical manufacturers provide evidence of safety of new industrial chemical substances before such substances can be marketed, this would no doubt have a ripple effect in academia, government, and the private sector. This ripple effect would effectively force changes in the current approach to chemical education, place more emphasis on mechanistic research in toxicology, and foster greater multidisciplinary collaboration in the research and development of safer commercial chemicals. 

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