Wurster System

Nozzle port size is also selected to accomodate desired spray rate and viscosity. The position of the nozzle is very significant. In top spray coating operations, the nozzle is positioned to spray liquid counter currently to the flow of product (see Figure 3). In the Wurster system, the nozzle sprays concurrently with the well organized flow of substrate (see Figure 4), and in the rotor technique, the nozzle sprays concurrently in the spiralling bed of product (see Figure 5). 

Bottom-spray film coating is accomplished by means of the Wurster system, originally developed by Dr. D.E. Wurster (Wurster 1959). A scheme of the bottom-spray fluid bed is given in Figure 16.4. 

The simplest systems where electron-transfer chemiluminescence occurs on interaction of radical ions are radical-anion and radical-cation recombination reactions in which the radical ions are produced from the same aromatic hydrocarbon (see D, p. 128) by electrolysis this type of chemiluminescence is also called electro-chemiluminescence. The systems consisting of e.g. a radical anion of an aromatic hydrocarbon and some other electron acceptor such as Wurster s red are more complicated. Recent investigations have concentrated mainly on the energetic requirements for light production and on the primary excited species. 

Synthesis of novel polyelectrochromic materials with the new structural motif utilizing stabilized carbocations has been demonstrated by several examples. The Wurster type violene-cyanine hybrid systems (22z+ and 232+) exhibit the presumed two color changes. The new cyanine-cyanine hybrid system (24 ) with a cyanine unit at the one terminus exhibits three color changes. 

One-electron oxidation of aniline derivatives gives a radical-cation in which the unpaired electron is distributed over both the nitrogen atom and the aromatic system. The further reactions of these intermediates more resemble those of aromatic compounds than of aliphatic amines. Some of the radical-cations are very stable in solution Wurster s blue, prepared by oxidation of tetramethyl-1,4-pheny ene-diamine [152], and Wurster s red from N,N-dimethyI-l,4-phenylenediamine [153] have been known since 1879. They were recognised as radical-cations by Mi-chaelis [154]. 

From Wurster s salts and the Weitz system i/it is well known that the intermediate oxidation level of the radical cations ( violenes ) is characterized by an e ecially long wavelength absorption. This general behaviour may be demonstrated with 32, n = 1 In Fig. 7 the similar absorption curves of RED and OX can be seen from... 

Several other organic systems have been stndied as potential electrochromes because of their redox behaviour. These include carbazoles, methoxybiphenyls, fluorenones, benzoquinones, naphthaquinones and anthraqninones, tetracyanoquinodimethane, tetrathiafnlvalene and pyrazolines. ° Of particnlar interest are the 1,4-phenylenedi-amines, which form highly colonred species on oxidation. These, known as Wurster s salts, exemplified by Wnrster s Bine (1.97), are anodically colouring and this type of material has found nse in composite electrochromic systems for car rearview mirrors (see 1.5.4.1). 

Wurster in 1879 had already prepared crystalline salts containing radical cation 23 (equation 12). Subsequently, radical cations of many different structural types have been found, especially by E. Weitz and S. Hunig, and recently these include a cyclophane structure 24 containing two radical cations (Figure 3). Leonor Michaelis made extensive studies of oxidations in biological systems, " and reported in 1931 the formation of the radical cation species 25, which he designated as a semiquinone. Michaelis also studied the oxidation of quinones, and demonstrated the formation of semiquinone radical anions such as 26 (equation 13). Dimroth established quantitative linear free energy correlations of the effects of oxidants on the rates of formation of these species. ... 

Effective product and process optimization play a prominent role in any successful scale-up study. As an illustration, this case study summarizes the initial development, and subsequent scale-up, of a Wurster process designed to facilitate the application of an aqueous ethylcellulose dispersion to drug-loaded pellets. At the same time, it was intended to deal, up front, with some of the idiosyncrasies of such a coating system that often influence the functionality of the final dosage form. 

In looking at the need for encapuslation in a product it should be emphasized that microcapsules are rarely sold and consumed by themselves. Microcapsules are generally additives to a larger system and must function within that system. Consequently there are a number of performance requirements placed on microcapsules when a limited number of encapsulating materials and methods exist. Consequently it is necessary to make a number of tradeoffs and compromises to incorporate microcapsules into a food product as an additive. In contrast to this, though, there is the continual development of new materials for encapsulation, particluarly in the Wurster method. Fortunately a number of the patents have now expired and so it is possible for the encapsulator to use a number of methods without fear of patent infringement. 

The Wurster bottom spray system has also been used successfully to coat particles as small as 100 microns. Attempting to coat smaller particles may result in the same difficulties as discussed in the previous segment. Batch capacities range from a few hundred grams to approximately 600 kg. Because fluidization quality is affected by batch size, at least 50% of the volume outside of the partition should be occupied by the uncoated product. Finished product batch size (for fine and intermediate particles) can be determined by the following equation . 

The energy of a single photon is obviously insufficient to ionize an organic compound. As early as the nineteen forties (3, 4), however, it -was observed that Wurster blue cation radical is produced by photoirradiation of 3-methylpentane glass containing N,N-tetramethyl p-phenylenediamine (TMPD) at 77° K. The recent detailed study of this system by electric conductivity measurement (5, 6) and electronic spectroscopy (7) provided conclusive evidence that the ionization is brought about via excitation to the triplet state followed by successive photoabsorption at the triplet state. This mechanism is supported by the facts that the life-time of the photochemical intermediate is identical with that of phosphorescence and the formation of Wurster blue, and that phosphorescence is inhibited in the presence of triplet scavengers. 

GM (2001). Well-to-wheel energy use and greenhouse gas emissions of advanced fuel/vehicle systems - North American analysis. Report from General Motors Corp., Argonne Nat. Lab., BP, ExxonMobil and Shell. (For adjacent European study see Wurster, 2003). 

Wurster, R. (2003). GM well-to-wheel-Studie - Ergebnisse and Schliisse. LB System-technik website http //www.HyWeb.de. 

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