Partial liquid ventilations

T. H. Shaffer, Partial liquid ventilation in critically ill infants receiving extracorporeal life support. Philadelphia Liquid Ventilation Consortium, Pediatrics 99 (1997) E2. 

M.Q. Huang, Q. Ye, D.S. Williams, C. Ho, MRI of lungs using partial liquid ventilation with water-in-perfluorocarbon emulsions, Magn. Reson. Med. 48 (2002) 487-492. 

The demonstration of the potential of this stable and obviously excellently tolerated compound has inspired a great number of scientists to develop PFCLs as special tools for medical applications and to introduce therapies using the outstanding behaviours of PFCLs, like the well-known concepts of complete and partial liquid ventilation [4], oxygen support of the skin, wound treatment [5], artificial tears [6], and ocular endotamponade media [1], to name only a few. Until now, the mouse submersed in PFCLs is often used as an eye-catcher for the demonstration of the biocompatibility of PFCLs even in cases where the topic of the presentation is not reflected by this experiment. 

C.L. Leach, J.S. Greenspan, D. Rubenstein, T.H. Shaffer, M.R. Wolfson, J.C. Jackson, R. DeLemos, B.P. Fuhrman, Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. New Engl. J. Med. 335 (1996) 761-766. 

R.B. Hirschl, M. Croce, D. Gore, H. Wiedemann, K. Davis, R.H. Bartlett, Prospective, randomized, controlled pilot study of partial liquid ventilation in adult acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 165 (2002) 781-787. 

J.P. Meinhardt, U. Friess, H.J. Bender, R.B. Hirschl, M. Quintel, Relationship among cardiac index, inspiration/expiration ratio, and perfluorocarbon dose during partial liquid ventilation in an oleic acid model of acute lung injury in sheep, J. Pediatr. Surg. 40 (2005) 1395-1403. 

A.T. Rotta, B. Gunnarsson, L.J. Hernan, B.P. Fuhrman, D.M. Steinhorn, Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids, Crit. Care Med. 28 (2000) 202-208. 

U. Merz, B. Klosterhalfen, M. Hausler, M. Kellinghaus, T. Peschgens, H. Homchen, Partial liquid ventilation reduces release of leukotriene B4 and interleukin-6 in bronch-oalveolar lavage in surfactant-depleted newborn pigs, Pediatr. Res. 51 (2002) 183-189. 

M. Gama de Abreu, A.D. Quelhas, P. Spieth, G. Brauer, L. Knels, M. Kasper, A.V. Pino, J.U. Bleyl, M. Hubler, F. Bozza, J. Salluh, E. Kuhlisch, A. Giannella-Neto, T. Koch, Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury, Anesthesiology 104 (2006) 278-289. 

Severe poisoning with modified-release verapamil was associated with respiratory failure in a 27-year-old man, who presented 2 hours after taking 24 g, one of the largest reported overdoses (24). He snrvived after receiving 4 days of partial liquid ventilation as a part of his medical management. 

Colton DM, Till GO, Johnson KJ, Dean SB, Bartlett RH, Hirschl RB. Neutrophil accumulation is reduced during partial liquid ventilation. Crit Care Med 1998 26 1716-1724. 

Croce MA, Fabian TC, Patton JH, Melton SM, Moore M, Trenthem LL. Partial liquid ventilation decreases the inflammatory response in the alveolar environment of trauma patients. J Trauma Injury Infect Crit Care 1998 45 273-282. 

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